1. Monomeric CRP is Elevated in Patients with COPD Compared to Non-COPD Control Persons
- Author
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Revathy Munuswamy, Wim Derave, Martijn A. Spruit, Luc Michiels, Jana De Brandt, Chris Burtin, Joseph Aumann, Pulmonologie, RS: NUTRIM - R3 - Respiratory & Age-related Health, MUNUSWAMY, Revathy, Derave, Wim, DE BRANDT, Jana, BURTIN, Chris, AUMANN, Joseph, SPRUIT, Martijn A., and MICHIELS, Luc
- Subjects
medicine.medical_specialty ,Immunology ,Pulmonary disease ,low-grade systemic inflammation ,RM1-950 ,Systemic inflammation ,Gastroenterology ,Internal medicine ,medicine ,Research Letter ,Medicine and Health Sciences ,Pathology ,Immunology and Allergy ,COPD ,mcrp ,RB1-214 ,In patient ,pCRP ,business.industry ,Dlow-grade systemic inflammation ,copd ,Serum samples ,medicine.disease ,Biomarker (medicine) ,mCRP ,Therapeutics. Pharmacology ,medicine.symptom ,business ,Journal of Inflammation Research ,pcrp - Abstract
Revathy Munuswamy,1,* Jana De Brandt,2,* Chris Burtin,2 Wim Derave,3 Joseph Aumann,4 Martijn A Spruit,5,6,* Luc Michiels1,* 1Faculty of Medicine and Life Sciences, Biomedical Research Institute BIOMED, Hasselt University, Hasselt, Belgium; 2Faculty of Rehabilitation Sciences, Rehabilitation Research Center REVAL, Biomedical Research Institute BIOMED, Hasselt University, Hasselt, Belgium; 3Department of Movement and Sports Sciences, Ghent University, Ghent, Belgium; 4Department of Pneumology, Jessa Hospital, Hasselt, Belgium; 5Department of Research and Development, CIRO, Horn, the Netherlands; 6Department of Respiratory Medicine, Maastricht University Medical Centre, Faculty of Health, Medicine and Life Sciences, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht, the Netherlands*These authors contributed equally to this workCorrespondence: Luc Michiels Email luc.michiels@uhasselt.beAbstract: Chronic low-grade systemic inflammation is frequently observed in patients with chronic obstructive pulmonary disease (COPD), e.g., elevated pentameric CRP (pCRP). However, pCRP can dissociate to form monomeric CRP (mCRP) which exhibits a clear pro-inflammatory behaviour in contrast to the more anti-inflammatory properties of pCRP. Therefore, mCRP may be an informative biomarker to demonstrate chronic low-grade systemic inflammation. This was confirmed by analysing serum samples from 38 patients with COPD and 18 non-COPD control persons (NCCP). mCRP was significantly elevated in patients with COPD vs. NCCP, indicating that mCRP might be considered as a new sensitive marker of chronic low-grade systemic inflammation.Keywords: COPD, low-grade systemic inflammation, pCRP, mCRP
- Published
- 2021