1. HOXB7 as a promising molecular marker for metastasis in cancers: a meta-analysis
- Author
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Liu FT, Ou YX, Zhang GP, Qiu C, Luo HL, and Zhu PQ
- Subjects
meta-analysis ,Homeobox gene ,HOXB7 ,metastasis ,carcinoma ,lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,lcsh:RC254-282 - Abstract
Fang-teng Liu, Yang-xi Ou, Guan-ping Zhang, Cheng Qiu, Hong-liang Luo, Pei-qian ZhuDepartment of Gastrointestinal Surgery, the Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province, People’s Republic of ChinaAbstract: Numerous studies on carcinoma have revealed that the expression level of HOXB7 in cancerous tissues was significantly higher than that in noncancerous tissues. Elevated expression of HOXB7 is associated with the susceptibility to lymph node metastasis and distant metastasis in various tumors. In this study, a meta-analysis was performed to involve majority of relevant articles and explore the association of HOXB7 expression level with metastasis in cancer patients. Literature retrieval was conducted by searching in a number of electronic databases (upto December 1, 2015). The meta-analysis was conducted with RevMan 5.3 software and Stata SE12.0. A total of 1,532 patients with carcinoma from 14 studies were included in analysis. The results of meta-analysis demonstrated that lymph node metastasis was observed more frequently in the patients group with high expression level of HOXB7 than in the patients group with low expression level of HOXB7 (odds ratio =2.17, 95% CI: 1.74–2.71, P
- Published
- 2016