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Shujing Lu,1 Zhengyang Yu,2 Xia Zhang,2 Lingling Sui2 1Department of Critical Care Medicine, Liaocheng Third People’s Hospital, Liaocheng 252000, Shandong, People’s Republic of China; 2Department of Internal Neurology, Liaocheng Third People’s Hospital, Liaocheng 252000, Shandong, People’s Republic of ChinaCorrespondence: Lingling SuiDepartment of Internal Neurology, Liaocheng Third People’s Hospital, No. 62 Weiyu Road, Liaocheng 252000, Shandong, People’s Republic of ChinaTel +86 635-8385120Email shaganna040996653@163.comObjective: Glioma is the most common malignant brain tumor that has high aggressiveness. The aim of thisstudy was to investigate the potential therapeutic targets for gliomas.Materials and Methods: Real-timequantitative polymerase chain reaction (RT-qPCR) was employed to calculate the expression of miRNA and genes. The connection between the expression of miR-483 and patients’ overall survival rate was evaluated using Kaplan–Meier analysis. In addition, the underlying mechanism was detected using luciferase assay.Results: The expression level of miR-483 was significantly decreased in glioma tissue samples and cell lines, compared to the adjacent tissues and normal cell lines. Downregulation of miR-483 or upregulation of SOX3 was associated with overall survival of glioma patients. Additionally, overexpression of miR-483 promotes cell invasion and migration and inhibits apoptosis. In addition, miR-483 directly targeted to SOX3, and the expression of miR-483 hasa negative correlation with SOX3 in glioma tissues. SOX3 reversed partial functions of miR-483 on cell migration, invasion, and promoted cell apoptosis in glioma.Conclusion: MiR-483 inhibited glioma cell migration, invasion, and promoted glioma cell apoptosis by targeting SOX3. MiR-483 maybe acted as a potential target for the treatment of glioma.Keywords: miR-483, SOX3, glioma, apoptosis, invasion