1. CUX2 functions as an oncogene in papillary thyroid cancer.
- Author
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Sun, Yihan, Ye, Danrong, Li, Yuefeng, Chen, Endong, Hao, Rutian, Cai, Yefeng, Wang, Qingxuan, Wang, Ouchen, and Zhang, Xiaohua
- Subjects
THYROID cancer ,WESTERN immunoblotting ,COCARCINOGENS ,CANCER invasiveness - Abstract
Background: In recent years, the incidence of thyroid cancer (TC), the most common endocrine malignancy, has been increasing. Emerging evidence indicates that the CUT/CUX/CDP family of proteins can play an important role in tumor development and progression by regulating many cancer-related functions. However, the molecular functions of CUX2 in TC remain unknown. Methods: In this study, we used a series of loss-of-function experiments and Western blot analysis to investigate the function of CUX2 in TC and the mechanisms involved. Results: Our data revealed that CUX2 expression levels were upregulated in papillary thyroid cancer (PTC). Functionally, CUX2 silencing significantly inhibited PTC cell line (KTC-1 and BCPAP) proliferation, colony formation, migration, invasion, and apoptosis. Furthermore, CUX2 induced epithelial–mesenchymal transition (EMT) and influenced the phosphorylation of AKT and mTOR in the PI3K–AKT–mTOR pathways. Conclusion: In summary, CUX2 may function as a tumor promoter in TC. [ABSTRACT FROM AUTHOR]
- Published
- 2019
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