1. Metagenomic Next-Generation Sequencing for the Diagnosis of Suspected Opportunistic Infections in People Living with HIV.
- Author
-
Xu, Jingying, Huang, Qian, Yu, Jianhua, Liu, Shourong, Yang, Zongxing, Wang, Fei, Shi, Yue, Li, Er, Li, Zhaoyi, and Xiao, Yunlei
- Subjects
HIV-positive persons ,OPPORTUNISTIC infections ,NUCLEOTIDE sequencing ,CENTRAL nervous system infections ,METAGENOMICS ,DIAGNOSIS - Abstract
Although the diagnostic performance of mNGS in varying patient populations and with varying infection types has previously been studied,[9],[10] its application in HIV patients with suspected opportunistic infections requires further examination. Materials and Methods Study Design and Patient Population We retrospectively investigated 46 suspected opportunistic infections in PLWH hospitalized atHangzhou Xixi Hospital from January 2020 to August 2021 and collected 49 total samples (3 patients provided 2 samples). Keywords: metagenomic next-generation sequencing; infection; aetiological diagnosis; HIV; opportunistic infections EN metagenomic next-generation sequencing infection aetiological diagnosis HIV opportunistic infections 1767 1775 9 05/11/22 20220401 NES 220401 Introduction AIDS remains a major global health threat. The CD4 SP + sp T cell count of patients with clear pathogens was significantly lower than that of patients with unclear pathogens (68 (16-168.5) vs 165.5 (61-294.25) P=0.043, Figure 2). [Extracted from the article]
- Published
- 2022
- Full Text
- View/download PDF