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Teguh Marfen Djajakusumah, Putie Hapsari, Prapanca Nugraha, Arrayyan Muhammad, Kiki Lukman Department of Surgery, Faculty of Medicine, Universitas Padjadjaran/Dr. Hasan Sadikin General Hospital, Bandung, IndonesiaCorrespondence: Kiki Lukman; Teguh Marfen Djajakusumah, Email kiki.lukman@unpad.ac.id; marfen.djajakusumah@unpad.ac.idBackground: End-stage kidney disease (ESKD) is associated with a tremendous financial burden. Data in Indonesia shows an increasing number of patients with ESKD taking hemodialysis as a routine procedure every year. Establishment and maintenance of vascular access are important in the management of ESKD. Vascular complications that often arise due to hemodialysis are common and one of the main reasons for hospitalization. Cannulation complications ranged from minor hematomas to acute bleeding from pseudoaneurysms that required emergency surgical procedures. This study aims to assess the different clinicopathological characteristics of ESKD patients with vascular access cannulation complications and the surgical management related to the complications.Materials and Methods: This research is a retrospective observational study. The research subjects in this study were ESKD patients in the vascular and endovascular surgery division of the tertiary hospital in West Java, Indonesia. There were 121 study subjects. Clinicopathological characteristics of vascular cannulation complications and surgical management are extracted from the medical record.Results: Three major vascular complications were ruptured pseudoaneurysms 64/121 (52.9%), impending rupture pseudoaneurysms 28/121 (23.1%), and pseudoaneurysms 21/121 (17.4%). Common surgical procedures were ligation of the draining vein 47/121 (38.8%), arterial primary repair 28/121 (23.1%), and arterial patch repair 18/121 (14.9%). There was a significant relationship between symptoms of bleeding in ruptured pseudoaneurysms and bulging masses in pseudoaneurysms (p = 0.001). There was a significant rela

Harlan Kasyfil Aziz,1 Yohana Azhar,2 Irra Rubianti Widarda,2 Maman Abdurahman,2 Zuldi Erdiansyah,1 Prapanca Nugraha,1 Kiki Lukman1 1Department of Surgery, Faculty of Medicine, University of Padjadjaran, Bandung, West Java, Indonesia; 2Department of Surgery, Dr. Hasan Sadikin General Hospital, Bandung, West Java, IndonesiaCorrespondence: Kiki Lukman; Yohana Azhar, Email kiki.lukman@unpad.ac.id; r.yohana@unpad.ac.idObjective: Breast cancer is the most prevalent cancer in women and can spread to the lymph nodes in the axilla. The sentinel lymph node is the first lymph node to be targeted for the spread or metastasis of cancer cells involving the lymph nodes. The aim of this study is to compare the accuracy rate of methylene blue injection into sentinel lymph nodes in early-stage breast cancer patients who have undergone incisional and excisional biopsies.Methods: This is a prospective observational study conducted in two general hospitals in West Java, Indonesia. The research subjects in this study were early-stage breast cancer patients with no lymph node metastasis (N0) who had undergone a biopsy. There were 83 study subjects included in this study. The sentinel lymph node biopsy was taken after injection of methylene blue into the peritumoral area. Blue nodes in the axilla were marked as positive lymph node biopsy results and sent for histopathology examination.Results: Patients who underwent excisional biopsy surgery had a sensitivity rate of 85.3% and a specificity of 93.3%, while the accuracy rate in patients who underwent incisional biopsy surgery had a sensitivity rate of 79.2% and a specificity of 80%.Conclusion: There was no difference in the accuracy of SLNB using methylene blue in patients with early-stage breast cancer with N0 who had a history of incisional and excisional biopsy.Keywords: biopsy, breast cancer, methylene blue, sentinel lymph nodes

Rinto Susilo,1,2 Ajeng Diantini,2 Kiki Lukman,3 Dyah Aryani Perwitasari,4 Aan Kunaedi1 1Department of Pharmacology and Clinical Pharmacy, College of Pharmacy Muhammadiyah Cirebon, Cirebon, Indonesia; 2Faculty of Pharmacy, Padjadjaran University, Bandung, Indonesia; 3Faculty of Medicine, Padjadjaran University, Indonesia, Digestive Surgeon Consultant at Hasan Sadikin Hospital, Bandung, Indonesia; 4Faculty of Pharmacy, Ahmad Dahlan University, Yogyakarta, IndonesiaCorrespondence: Dyah Aryani Perwitasari, Faculty of Pharmacy, Ahmad Dahlan University, Prof. Dr. Soepomo Janturan, Yogyakarta, 55165, Indonesia, Tel +62 812-2965-376, Fax +62 0274563515, Email dyah.perwitasari@pharm.uad.ac.idIntroduction: Assessment of the severity of adverse drug reaction (ADR) is very rare in Indonesia. The severity of ADR can describe how serious this affects the clinical condition of the patient. In Indonesia, there are no instruments used to measure the severity of ADR.Purpose: This study aims to translate, pilot test, and validate Hartwig instruments for measuring the severity of ADR in colorectal cancer patients in Indonesia.Patients and Methods: The translation method was used forward-backward technique from English to Indonesian, then being retranslated from Indonesia to English. The instrument of Indonesian version was used to assess the severity of ADR as the effect of chemotherapy. The assessment was conducted to 10 colorectal cancer patients by 30 health workers. The test validity was done based on content validity ratio (CVR) and content validity index (CVI); meanwhile, the test reliability was based on intraclass coefficient correlation (ICC).Results: All of the results of CVR present a value of > 0.33, while the range of CVI moves between 0.8 to 1.0, which declares that the instrument is valid. The satisfactory alpha value for reliability is 0.996 with signification of 0.197 (p > 0.05) based on ANOVA analysis. Meanwhile, the ICC value of 0.896 indicates a good r