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Amaylia Oehadian,1 Andini Kartikasari,2 Lusi Mersiana,1 Stephanie Victoria Gunadi,3 Gusti Fungani,1 Putri Vidyaniati,1 Dimmy Prasetya,1 Indra Wijaya,1 Pandji Irani Fianza,1 Trinugroho Heri Fadjari,1 Nanny Natalia Sutedjo4 1Division of Hematology and Oncology Medic, Internal Medicine Department, Faculty of Medicine, Padjadjaran University/ Dr. Hasan Sadikin General Hospital, Bandung, Indonesia; 2Bandung City Regional General Hospital, Bandung, Indonesia; 3Internal Medicine Department, Faculty of Medicine, Padjadjaran University/ Dr. Hasan Sadikin General Hospital, Bandung, Indonesia; 4Endocrinology and Metabolism Division, Internal Medicine Department, Faculty of Medicine, Padjadjaran University/ Dr. Hasan Sadikin General Hospital, Bandung, IndonesiaCorrespondence: Amaylia Oehadian, Department of Internal Medicine, Padjadjaran University/ Dr. Hasan Sadikin General Hospital, Jl. Pasteur No. 38, Pasteur, Bandung, West Java, 40161, Indonesia, Email amaylia.oehadian@unpad.ac.idBackground: No specific data have been systematically collected regarding lymphoma patient characteristics, while non-Hodgkin lymphoma (NHL) is identified as the 7th most common cancer and Hodgkin lymphoma (HL) is the 28th. Inflammation plays an important role in the pathogenesis and progression of lymphoma. Malnutrition is an adverse prognostic factor in lymphoma. Systemic Inflammatory Index (SII), Prognostic Nutritional Index (PNI), and Advanced Lung Cancer Inflammation Index (ALI) were biomarkers depicting inflammation and nutritional status. This study aims to describe the clinical and biomarker characteristics of both HL and NHL patients.Methods: This descriptive study used a cross-sectional design, and data were collected from Hasan Sadikin Hospital lymphoma registry from January 2020 to November 2023. Demographic, staging, and histopathological data were extracted. Three biomarkers were evaluated. Survival curves were drawn using Kaplan–Meier curve analysis, and the log rank test was used

Pandji Irani Fianza,1 Anita Rahmawati,1 Indra Wijaya,1 Amaylia Oehadian,1 Dimmy Prasetya,1 Putri Vidyaniati,1 Gusti Fungani Harti,1 Trinugroho Heri Fadjari,1 Ramdan Panigoro2 1Division of Hematology and Medical Oncology, Department of Internal Medicine, Faculty of Medicine, Universitas Padjadjaran/Hasan Sadikin General Hospital, Bandung, Indonesia; 2Department of Biomedical Sciences, Faculty of Medicine, Universitas Padjadjaran, Bandung, IndonesiaCorrespondence: Pandji Irani Fianza, Department of Internal Medicine, Division of Hematology and Medical Oncology, Faculty of Medicine, Universitas Padjadjaran/Hasan Sadikin General Hospital, Pasteur Street No. 38, Bandung, Indonesia, Tel +62-22-203-4954, Email pandji.irani.fianza@unpad.ac.idAbstract: Thalassemia is a chronic disease caused by impaired globin chain synthesis, leading to ineffective erythropoiesis, hemolysis, and chronic anemia. The treatment of patients with thalassemia, including blood transfusion combined with chelation therapy has progressed and improved their survival and prognosis. However, thalassemia-related psychological problems and impaired health-related quality of life (QoL) challenges still exist. Gender is one of the factors that has been suggested, to contribute to the disparities in psychological outcomes. This review article examined the evidence for gender differences in psychological disturbances and QoL in adolescent and adult patients with thalassemia. A non-systematic search of the literature was conducted in PubMed and Google Scholar for English full-text available from 2013 to 2023. We identified 23 studies with a sample size ≥ 100 that examined gender disparities in anxiety, depression, and QoL in adolescent and adult patients with thalassemia (mean prevalence of female = 53.1%; mean age = 28 years). Our review shows that there are gender disparities in psychological distress and QoL in adolescent and adult patients with thalassemia. Statistically significant gender differences we

Amaylia Oehadian,1 Ian Huang,2,3 Andini Kartikasari,4 Bachti Alisjahbana,5 Delita Prihatni6 1Division of Hematology and Oncology Medic, Department of Internal Medicine Faculty of Medicine, Universitas Padjadjaran/Dr. Hasan Sadikin General Hospital, Bandung, Indonesia; 2Department of Internal Medicine Faculty of Medicine, Universitas Padjadjaran/Dr. Hasan Sadikin General Hospital, Bandung, Indonesia; 3Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Banten, Indonesia; 4Bandung City Regional General Hospital, Bandung, Indonesia; 5Division of Infectious and Tropical Diseases, Department of Internal Medicine Faculty of Medicine, Universitas Padjadjaran/Dr. Hasan Sadikin General Hospital, Bandung, Indonesia; 6Department of Clinical Pathology Universitas Padjadjaran/Dr. Hasan Sadikin General Hospital, Bandung, IndonesiaCorrespondence: Amaylia Oehadian, Department of Internal Medicine, Padjadjaran University/Dr. Hasan Sadikin General Hospital, Jl. Pasteur No. 38, Bandung, West Java, 40161, Indonesia, Email amaylia.oehadian@unpad.ac.idBackground: During COVID-19 pandemic, it is difficult to distinguish febrile patient infected by SARS-CoV-2 or bacterial causes. Howell-Jolly bodies are a well-known entity found in red blood cells. They are nuclear fragments, composed of deoxyribonucleic acid, commonly observed in the peripheral blood smears of hyposplenic or asplenic patients. Recently, similar inclusions often referred to as Howell-Jolly body-like inclusions (HJBLIs) have been reported in the neutrophils of patients with acquired immune deficiency syndrome (AIDS) and COVID-19 patient.Aim: To explore whether HJBLIs in peripheral blood smear could differentiate between patients with confirmed SARS-CoV-2 and bacterial pneumonia.Methods: We performed cross-sectional study using secondary data from COVID-19 database and re-evaluated peripheral blood smears to identify HJBLIs. We included confirmed COVID-19 adults age > 18 years who were hospitalized in Dr. Hasan Sa

Silvita Fitri Riswari,1,2 Muhammad Fitriandi Budiman,2,3 Dera Darmayanti,2 Ernawati,2 Susantina Prodjosoewojo,2,3 Evan Susandi,2,3 Amaylia Oehadian,3 Bachti Alisjahbana2,3 1Department of Biomedical Sciences, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia; 2Research Center for Care and Control of Infectious Diseases, Universitas Padjadjaran, Bandung, Indonesia; 3Department of Internal Medicine, Hasan Sadikin General Hospital, Bandung, IndonesiaCorrespondence: Bachti Alisjahbana, Tel +62 823 9841 5612, Fax +62 22 204 4128, Email b.alisjahbana@gmail.comPurpose: Practical methods for detecting plasma leakage should be readily available in all areas where dengue is endemic. We compared the accuracy of measurements obtained with a handheld HemoCue® Hb 201 instrument used for hemoglobin point-of-care testing (Hb-POCT) with that of measurements of hematocrit (Ht) levels for detecting plasma leakage in dengue patients.Patients and Methods: We performed both measurements using the HemoCue® Hb201 system and microhematocrit method on EDTA blood taken from dengue patients at three time points during their hospitalization. Ascites, pleural effusion, or gallbladder thickening determined through ultrasound examinations were considered the gold standard for determining dengue hemorrhagic fever (DHF) versus dengue fever (DF).Results: Close agreement between Hb-POCT and Ht measurements was indicated by an r square value of 0.845 in a linear regression. The sensitivity results for distinguishing between DHF and DF at admission were similar for Hb-POCT (63.6%) and Ht (66.7%) (Kappa = 0.75) using the optimal cutoff point determined via ROC analysis. Delta differences (in percentage) for Hb-POCT and Ht between the highest and lowest values showed lower sensitivity (45.5% and 48.5%, respectively; Kappa 0.60) when the optimal cutoff point was applied. Recommended cutoffs of ≥ 20% to confirm plasma leakage provided a slightly higher sensitivity using Hb-POCT (18.2%) com