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During the therapy with antidepressive agents, for the reason of its duration, numerous drug-drug interactions may occur. Antidepressive agents inhibit P450 enzyme activity and interfere with other drug metabolism. Many interactions are acceptable from the clinical point of view, and some are seriously dangerous indicating a need for their better knowledge. The aim of this work is to point out the possible interactions between antidepressive agents and other drugs.

The Parkinsonism disease has chronical degenerative disease of the nervous system, which has the progressive course. The therapeutic value of the drugs weakens by course of the year, and the nondesired effects become more expressed. Thanks to the researches and new medicaments in the last tenth years have significantly widened the possibility for treating and control of the symptoms of Parkinsonism disease. The knowing of the mechanism of the action dosage, undesired effects, and the interaction of the drugs makes easier the specific parkinsonism therapy.