1. Synchronous rosette-forming glioneuronal tumor and diffuse astrocytoma with molecular characterization: a case report.
- Author
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Cachia D, Prado MP, Theeler B, Hamilton J, McCutcheon I, and Fuller GN
- Subjects
- Adult, Astrocytoma diagnosis, Brain pathology, Brain physiopathology, Brain Neoplasms diagnosis, Cerebral Ventricle Neoplasms diagnosis, Female, Fourth Ventricle pathology, Ganglioglioma diagnosis, Humans, Neoplasms, Neuroepithelial pathology, Astrocytoma pathology, Brain Neoplasms pathology, Cerebral Ventricle Neoplasms pathology, Ganglioglioma pathology, Rosette Formation
- Abstract
Rosette-forming glioneuronal tumor (WHO grade I) is a rare neoplasm primarily arising in young adults that is characterized by distinctive neurocytic rosette formation, a spindled glial component resembling pilocytic astrocytoma, and a high incidence of PIK3CA mutation. Low-grade diffuse astrocytoma (WHO grade II), on the other hand, is far more common and is characterized by a high incidence of IDH mutation. Here we report a patient with simultaneous presentation of a midbrain-cerebellar rosetteforming glioneuronal tumor and a cerebral diffuse astrocytoma. Molecular characterization of both tumors confirmed characteristic, mutually exclusive, distinct signatures, with the rosette-forming glioneuronal tumor exhibiting a previously unreported novel PIK3CA gene mutation.
- Published
- 2014
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