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25 results on '"Wurpts, A"'

1. Allergologische Diagnostik von Überempfindlichkeitsreaktionen auf Arzneimittel

Author

Brockow, K., primary, Wurpts, G., additional, Trautmann, A., additional, Pfützner, W., additional, Treudler, R., additional, Bircher, A.J., additional, Brehler, R., additional, Buhl, T., additional, Dickel, H., additional, Fuchs, T., additional, Jakob, T., additional, Kurz, J., additional, Kreft, B., additional, Lange, L., additional, Merk, H.F., additional, Mockenhaupt, M., additional, Mülleneisen, N., additional, Ott, H., additional, Ring, J., additional, Ruëff, F., additional, Sachs, B., additional, Sitter, H., additional, Wedi, B., additional, Wöhrl, S., additional, Worm, M., additional, and Zuberbier, T., additional

Published
2023
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2. Patients with questionable penicillin (beta-lactam) allergy: Causes and solutions

Author

Knut, Brockow, Gerda, Wurpts, and Axel, Trautmann

Subjects
General Engineering, General Earth and Planetary Sciences, General Environmental Science
Abstract

In Europe, North America, and Australia, 5% to 10% of the population are now classified as penicillin (β-lactam) allergic. Only ~ 10% of these questionable diagnoses, mostly made in childhood, can be confirmed by allergy diagnostics.The aim of this review is to show causes and consequences as well as recommendations for dealing with the often questionable diagnosis of penicillin (β-lactam) allergy (BLA).An incorrect BLA diagnosis may negatively impact antibiotic treatment needed in the future, by using a less effective antibiotic or using a broad-spectrum antibiotic, for example, further exacerbating the problem of increasing antibiotic resistance. Accordingly, there is growing pressure from antibiotic stewardship programs to critically challenge the BLA diagnosis. Conservatively, a suspected BLA is reviewed by an allergist using medical history, skin testing, laboratory testing, and provocation. This clarification is costly and is not remunerated in the German health care system; that is the reason why this testing is only offered in a few specialized clinics and practically not at all in general practice. In view of thousands of affected patients, additional strategies are needed to treat patients with a low risk of hypersensitivity reaction despite suspected allergy with a β-lactam antibiotic. In recent years, various methods have been proposed to eliminate suspected allergy as promptly as possible and directly before necessary treatment with a β-lactam antibiotic, including standardized history (also in the form of an algorithm), skin test with immediate reading after 15 minutes, or administration of a small test dose. Investigations of small case series and also multi-center studies to date have yielded promising results in terms of feasibility and safety.Of the large number of patients with (questionable) BLA, most have never been tested and - if antibiotic treatment becomes necessary - simply receive an alternative antibiotic. The diagnosis of BLA therefore requires new approaches besides classical allergy testing to critically question BLA.

Published
2022
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4. Guideline for allergological diagnosis of drug hypersensitivity reactions

Author

Brockow, Knut, primary, Wurpts, Gerda, additional, Trautmann, Axel, additional, Pfützner, Wolfgang, additional, Treudler, Regina, additional, Bircher, Andreas J., additional, Brehler, Randolf, additional, Buhl, Timo, additional, Dickel, Heinrich, additional, Fuchs, Thomas, additional, Jakob, Thilo, additional, Kurz, Julia, additional, Kreft, Burkhard, additional, Lange, Lars, additional, Merk, Hans F., additional, Mockenhaupt, Maja, additional, Mülleneisen, Norbert, additional, Ott, Hagen, additional, Ring, Johannes, additional, Ruëff, Franziska, additional, Sachs, Bernhardt, additional, Sitter, Helmut, additional, Wedi, Bettina, additional, Wöhrl, Stefan, additional, Worm, Margitta, additional, and Zuberbier, Torsten, additional

Published
2023
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5. Praktische Empfehlungen zur allergologischen Risikoabschätzung der COVID- 19-Impfung

Author

W. Pfuetzner, U. Raap, Andrea Bauer, Bettina Wedi, D. Dickel, T. Zuberbier, Timo Buhl, Norbert Mülleneisen, T. Jacob, H.F. Merk, Knut Brockow, Regina Treudler, J. Kleine-Tebbe, J. Fluhr, Ludger Klimek, M. Worm, S. Roeseler, and Gerda Wurpts

Subjects
2019-20 coronavirus outbreak, Pediatrics, medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), business.industry, Therapeutic Procedure, Context (language use), macromolecular substances, Computer-assisted web interviewing, Vaccination, Immunology and Allergy, Medicine, In patient, business, Risk assessment
Abstract

Severe allergic reactions to vaccines are very rare Single severe reactions have occurred worldwide after vaccination with the new mRNA-based COVID-19 vaccines PEG2000 is discussed as a possible trigger We provide guidance on risk assessment regarding COVID-19 vaccination in patients with allergic diseases and suggest a standardized, resource-oriented diagnostic and therapeutic procedure Reports of severe allergic reactions in the context of COVID-19 vaccination can be made via www anaphylaxie net using an online questionnaire

Published
2021
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6. Induction of penicillin tolerance during pregnancy: Allergological opinion on the recommendation of the current AWMF Guidelines on Diagnosis and Treatment of Syphilis (AWMF Registry No. 059-002)

Author

Wolfgang Pfützner, Hans F. Merk, Cord Sunderkötter, Burkhard Kreft, Gerda Wurpts, Axel Trautmann, Franziska Ruëff, Werner Aberer, Norbert Mülleneisen, Regina Treudler, Bettina Wedi, Thilo Jakob, Stefani Röseler, Margitta Worm, Vera Mahler, Randolf Brehler, Hagen Ott, Heinrich Dickel, and Knut Brockow

Subjects
penicillin allergy, tolerance induction, Pregnancy, Pediatrics, medicine.medical_specialty, Allergy, business.industry, medicine.medical_treatment, syphilis, desensitization, General Engineering, Penicillin allergy, medicine.disease, Penicillin, Tolerance induction, medicine, General Earth and Planetary Sciences, Syphilis, Statement, pregnancy, business, General Environmental Science, medicine.drug, Desensitization (medicine)
Abstract

Not available.

Published
2021
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10. Wir stellen uns vor: ACAC – Aachener Comprehensive Allergy Center

Author

Wurpts, G., primary, Yazdi, A.S., additional, Merk, H.F., additional, Huth, L., additional, Baron, J.M., additional, Dreher, M., additional, Müller, T., additional, Kraus, T., additional, Markert, A., additional, Hackenberg, S., additional, Röseler, S., additional, Lehmann, S., additional, and Tenbrock, K., additional

Published
2021
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13. 'Neue' inhalative Pflanzenallergene

Author

H.F. Merk, Thomas Kraus, A. Chaker, J.M. Baron, S. Moll Slodowy, Wolfgang Dott, L. Kaiser, Wolfgang Straff, H.-G. Mücke, G. Laven, H. Bier, Galina Balakirski, Z. Hajdu, Gerda Wurpts, S. Röseler, Murat Bas, K. Fietkau, C. Höflich, and A. Yazdi

Subjects
Immunology and Allergy
Published
2019
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14. Penicillin-Toleranzinduktion in der Schwangerschaft: Allergologische Stellungnahme zur Empfehlung der aktuellen Leitlinie Diagnostik und Therapie der Syphilis (AWMF-Register-Nr. 059-002)

Author

Wedi, B., primary, Aberer, W., additional, Brockow, K., additional, Dickel, H., additional, Brehler, R., additional, Jakob, T., additional, Kreft, B., additional, Mahler, V., additional, Merk, H.F., additional, Mülleneisen, N., additional, Ott, H., additional, Pfützner, W., additional, Röseler, S., additional, Ruëff, F., additional, Sunderkötter, C., additional, Trautmann, A., additional, Treudler, R., additional, Worm, M., additional, and Wurpts, G., additional

Published
2021
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15. Praktische Empfehlungen zur allergologischen Risikoabschätzung der COVID- 19-Impfung

Author

Worm, M., primary, Bauer, A., additional, Wedi, B., additional, Treudler, R., additional, Pfuetzner, W., additional, Brockow, K., additional, Buhl, T., additional, Zuberbier, T., additional, Fluhr, J., additional, Wurpts, G., additional, Klimek, L., additional, Jacob, T., additional, Merk, H.F., additional, Mülleneisen, N., additional, Roeseler, S., additional, Dickel, D., additional, Raap, U., additional, and Kleine-Tebbe, J., additional

Published
2021
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16. Practical recommendations for the allergological risk assessment of the COVID-19 vaccination – a harmonized statement of allergy centers in Germany

Author

Worm, Margitta, primary, Bauer, Andrea, additional, Wedi, Bettina, additional, Treudler, Regina, additional, Pfuetzner, Wolfgang, additional, Brockow, Knut, additional, Buhl, Timo, additional, Zuberbier, Torsten, additional, Fluhr, Joachim, additional, Wurpts, Gerda, additional, Klimek, Ludger, additional, Jacob, Thilo, additional, Merk, Hans F., additional, Mülleneisen, Norbert, additional, Roeseler, Stefani, additional, Dickel, Heinrich, additional, Raap, Ulrike, additional, and Kleine-Tebbe, Jörg, additional

Published
2021
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17. Induction of penicillin tolerance during pregnancy: Allergological opinion on the recommendation of the current AWMF Guidelines on Diagnosis and Treatment of Syphilis (AWMF Registry No. 059-002)

Author

Wedi, Bettina, primary, Aberer, Werner, additional, Brockow, Knut, additional, Dickel, Heinrich, additional, Brehler, Randolf, additional, Jakob, Thilo, additional, Kreft, Burkhard, additional, Mahler, Vera, additional, Merk, Hans F., additional, Mülleneisen, Norbert, additional, Ott, Hagen, additional, Pfützner, Wolfgang, additional, Röseler, Stefani, additional, Ruëff, Franziska, additional, Sunderkötter, Cord, additional, Trautmann, Axel, additional, Treudler, Regina, additional, Worm, Margitta, additional, and Wurpts, Gerda, additional

Published
2021
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19. Leitlinie Allergologische Diagnostik von Überempfindlichkeitsreaktionen auf Arzneimittel

Author

Knut Brockow, Hans F. Merk, Johannes Ring, T. Jakob, Margitta Worm, Andreas J. Bircher, Randolf Brehler, Torsten Zuberbier, Lars Lange, Maja Mockenhaupt, Gerda Wurpts, Hagen Ott, Werner Aberer, Bernhard Przybilla, Wolfgang Pfützner, Thomas Fuchs, Helmut Sitter, Regina Treudler, Bettina Wedi, Oliver Pfaar, Heinrich Dickel, Bernhardt Sachs, and Axel Trautmann

Subjects
Drug, medicine.medical_specialty, Allergy, business.industry, media_common.quotation_subject, Provocation test, Guideline, medicine.disease, Hypersensitivity reaction, Time course, Immunology and Allergy, Medicine, Drug intoxication, business, Intensive care medicine, Anaphylaxis, media_common
Abstract

Drug hypersensitivity reactions are unpredictable adverse drug reactions. They manifest either within 1 - 6 h following drug intake (immediate reactions) with mild-to-life-threatening symptoms of anaphylaxis, or several hours to days later (delayed reactions), primarily as exanthematous eruptions. It is not always possible to detect involvement of the immune system (allergy). Waiving diagnostic tests can result in severe reactions on renewed exposure on the one hand, and to unjustified treatment restrictions on the other. With this guideline, experts from various specialist societies and institutions have formulated recommendations and an algorithm for the diagnosis of allergies. The key principles of diagnosing allergic/hypersensitivity drug reactions are presented. Where possible, the objective is to perform allergy diagnostics within 4 weeks to 6 months following the reaction. A clinical classification of symptoms based on the morphology and time course of the reaction is required in order to plan a diagnostic work-up. In the case of typical symptoms of a drug hypersensitivity reaction and unequivocal findings from validated skin and/or laboratory tests, a reaction can be attributed to a trigger with sufficient confidence. However, skin and laboratory tests are often negative or insufficiently reliable. In such cases, controlled provocation testing is required to clarify drug reactions. This method is reliable and safe when attention is paid to indications and contraindications and perfouned under appropriate medical supervision. The results of the overall assessment are discussed with the patient and documented in an "allergy passport" in order to ensure targeted avoidance in the future and allow the use of alternative drugs where possible.

Published
2016
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20. “New” inhalant plant allergens

Author

Röseler, Stefani T.M., primary, Baron, Jens M., additional, Höflich, Conny, additional, Merk, Hans F., additional, Bas, Murat, additional, Bier, Henning, additional, Dott, Wolfgang, additional, Fietkau, Katharina, additional, Hajdu, Zuzanna, additional, Kaiser, Lorraine, additional, Kraus, Thomas, additional, Laven, Gottfried, additional, Moll-Slodowy, Silke, additional, Mücke, Hans-Guido, additional, Straff, Wolfgang, additional, Wurpts, Gerda, additional, Yazdi, Amir S., additional, Chaker, Adam, additional, and Balakirski, Galina, additional

Published
2020
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21. Guideline on diagnostic procedures for suspected hypersensitivity to beta-lactam antibiotics

Author

Wurpts, Gerda, primary, Aberer, Werner, additional, Dickel, Heinrich, additional, Brehler, Randolf, additional, Jakob, Thilo, additional, Kreft, Burkhard, additional, Mahler, Vera, additional, Merk, Hans F., additional, Mülleneisen, Norbert, additional, Ott, Hagen, additional, Pfützner, Wolfgang, additional, Röseler, Stefani, additional, Ruëff, Franziska, additional, Sitter, Helmut, additional, Sunderkötter, Cord, additional, Trautmann, Axel, additional, Treudler, Regina, additional, Wedi, Bettina, additional, Worm, Margitta, additional, and Brockow, Knut, additional

Published
2020
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22. S2k-Leitlinie: Diagnostik bei Verdacht auf eine Betalaktamantibiotika-Überempfindlichkeit

Author

Wurpts, G., primary, Aberer, W., additional, Dickel, H., additional, Brehler, R., additional, Jakob, T., additional, Kreft, B., additional, Mahler, V., additional, Merk, H.F., additional, Mülleneisen, N., additional, Ott, H., additional, Pfützner, W., additional, Röseler, S., additional, Ruëff, F., additional, Sitter, H., additional, Sunderkötter, C., additional, Trautmann, A., additional, Treudler, R., additional, Wedi, B., additional, Worm, M., additional, and Brockow, K., additional

Published
2019
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23. „Neue“ inhalative Pflanzenallergene

Author

Röseler, S., primary, Baron, J.M., additional, Höflich, C., additional, Merk, H.F., additional, Bas, M., additional, Bier, H., additional, Dott, W., additional, Fietkau, K., additional, Hajdu, Z., additional, Kaiser, L., additional, Kraus, T., additional, Laven, G., additional, Slodowy, S. Moll-, additional, Mücke, H.-G., additional, Straff, W., additional, Wurpts, G., additional, Yazdi, A., additional, Chaker, A., additional, and Balakirski, G., additional

Published
2019
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25. Leitlinie Allergologische Diagnostik von Überempfindlichkeitsreaktionen auf Arzneimittel

Author

Brockow, K., primary, Przybilla, B., additional, Aberer, W., additional, Bircher, A.J., additional, Brehler, R., additional, Dickel, H., additional, Fuchs, T., additional, Jakob, T., additional, Lange, L., additional, Pfützner, W., additional, Mockenhaupt, M., additional, Ott, H., additional, Pfaar, O., additional, Ring, J., additional, Sachs, B., additional, Sitter, H., additional, Trautmann, A., additional, Treudler, R., additional, Wedi, B., additional, Worm, M., additional, Wurpts, G., additional, Zuberbier, T., additional, and Merk, H.F., additional

Published
2016
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