1. Increased chemokine receptor IL-17RA expression is associated with poor survival in gastric cancer patients.
- Author
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Jiang YX, Li PA, Yang SW, Hao YX, and Yu PW
- Subjects
- Aged, Biomarkers, Tumor genetics, Blotting, Western, Cell Movement, Chi-Square Distribution, Female, Gene Expression Regulation, Neoplastic, Humans, Immunohistochemistry, Kaplan-Meier Estimate, Lymphatic Metastasis, Male, Middle Aged, Multivariate Analysis, Neoplasm Staging, Real-Time Polymerase Chain Reaction, Receptors, Interleukin-17 genetics, Risk Factors, Stomach Neoplasms genetics, Stomach Neoplasms mortality, Stomach Neoplasms pathology, Stomach Neoplasms therapy, Time Factors, Treatment Outcome, Up-Regulation, Biomarkers, Tumor analysis, Receptors, Interleukin-17 analysis, Stomach Neoplasms chemistry
- Abstract
Background: Previous researchers have identified that the chemokine interleukin-17 (IL-17) was associated with survival time of patients with gastric cancer, but the roles of its receptors (IL-17R) in gastric cancer remain unknown. Our studies were designed to clarify the function of IL-17RA and to explore their potential role in gastric cancer., Materials and Methods: The expression of IL-17RA was determined in primary gastric cancer tissues (n=101) using Real-time RT-PCR, immunohistochemistry, and western blotting. To investigate the functional significance of IL-17RA expression, IL-17RA expression and clinical parameters, multivariate survival was analyzed in patients with gastric cancer., Results: IL-17RA was overexpression in gastric cancer tissues compared with adjacent normal tissues (P<0.05). The elevated expression level of IL-17RA was observed correlated significantly with tumor progression (P=0.003), Lymphatic invasion (P=0.019), lymphoid nodal status (P=0.001), distant metastasis (P<0.001) of gastric cancer patients, TNM stage (P=0.0013) and was one of the independent prognostic factors for patient's overall survival., Conclusions: These results demonstrated that the expression of IL-17RA plays an important role in gastric cancer progression, migration and prognosis of gastric cancer. The IL-17-IL-17RA signaling mechanism may be a potential novel target.
- Published
- 2015