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The endometrium may be the most convenient object of forecasting the development of the large uterine fibroid, as the object is available in the diagnosis of diseases of the uterus, changes in its cytokine profile linked with the growth of uterine fibroid. Immunohistochemically identification of high expression of Ki 67, TGF-, PD-ECGF in the endometrium allows to predict the development of large uterine fibroids.

Tumors of the myometrium, reminiscent of leiomyoma with atypical location and aggressive growth, represent a diagnostic problem due to their common manifestations in various imaging techniques. These include various types of uterine leiomyomas, stromal endometrial tumors and rare tumors of cahal-like cells.

Leiomyoma of the uterus is a benign hormone-dependent tumors in women.The incidence of LM among gynecological diseases is 25 to 50%, according to different authors. In reproductive-aged women its frequency is about 30%. WHO recommends to allocate leiomyoma, which in russian literature often referred to as a simple or ordinary leiomyoma, and its histologic variants (cellular, mitotic activity, epithelioid, myxoid, atypical leiomyoma and lipoleyomioma etc.).We performed clinical and morphological analysis of atypical uterine leiomyoma in 44-year-old woman. Immunohistochemical study detected positive reaction to smooth muscle actin, dismin, progesterone receptors, N-caldesmon. Adverse reactions to c-kit, ER keratins. Proliferation index by Ki-67 does not exceed 10%. At the molecular genetic research in the studied loci, the microsatellite instability and loss of heterozygosity, characteristic of the LMS, were not revealed.

The pathology of cervical HPV infection is detected by three types of epithelial-mesenchymal spheroidal structures: reparative, neoplastic and cancerous involved in reparation processes and in tumor growth. Cancer spheroids are different from neoplastic not only larger in size but also a tendency to merge, and high expression of p53. Expression of tumor markers p53, p16 and Ki-67 could be used in the early differential diagnosis of precancer and squamous cell carcinoma of the cervix.