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According to the analysis results of the longterm treatment experience of more than 800 patients with osteosarcomas the authors began to perform the new record of the osteosarcoma treatment, the basic aims of which are the increase of the number of patients with promunced medicinal pathomorphism at the expence of more intensive preoperative chemotherapy. After chemotherapy intensification the incidence of side effects increases. The data on the osteosarcoma pathogenesis with the sexual steroid hormones are obtained. It is emphasized that the immediate and remote results of the extremity osteosarcoma treatment can be achieved only in the highly specialized centers provided with current diagnosis methods, treatment monitoring and supporting therapy measures.