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1. Pharmacology of 2-o-chlororbenzoyl-4-chloro-N-methyl-N alpha-glycylglycinanilide hydrate (45-0088-S), a compound with benzodiazepine-like properties.

Author

Hirose K, Matsushita A, Eigyo M, Jyoyama H, Fujita A, Tsukinoki Y, Shiomi T, and Matsubara K

Subjects
Aggression drug effects, Animals, Anti-Anxiety Agents toxicity, Anticonvulsants, Attention drug effects, Avoidance Learning drug effects, Benzophenones toxicity, Cats, Drug Interactions, Glycine analogs & derivatives, Glycine toxicity, Humans, Hypnotics and Sedatives pharmacology, Lethal Dose 50, Mice, Motor Activity drug effects, Muscle Relaxants, Central, Rats, Anti-Anxiety Agents pharmacology
Abstract

2-o-Chlorobenzoyl-4-chloro-N-methyl-N alpha-glycylglycinanilide hydrate (45-0088-S), a dipeptido-aminobenzophenone compound, inhibited pentetrazole-induced convulsion and suppressed electroshock-induced fighting behavior in mice, reduced conflict behavior in rats and monkeys, and induced muscle relaxation in cats at lower doses than did diazepam. This pharmacological profile suggests that 45-0088-S can be an active, water-soluble antianxiety agent in man.

Published
1981

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