1. Biotechnological approaches to the production of plant-derived promising anticancer agents: An update and overview.
- Author
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Changxing L, Galani S, Hassan FU, Rashid Z, Naveed M, Fang D, Ashraf A, Qi W, Arif A, Saeed M, Chishti AA, and Jianhua L
- Subjects
- Alkaloids chemistry, Alkaloids isolation & purification, Alkaloids therapeutic use, Animals, Antineoplastic Agents, Phytogenic chemistry, Antineoplastic Agents, Phytogenic isolation & purification, Biotechnology trends, Humans, Lignans chemistry, Lignans isolation & purification, Lignans therapeutic use, Paclitaxel chemistry, Paclitaxel isolation & purification, Paclitaxel therapeutic use, Antineoplastic Agents, Phytogenic therapeutic use, Biotechnology methods, Neoplasms drug therapy, Plants, Medicinal
- Abstract
The plant kingdom is a rich source of bioactive compounds, many of which have been used since pre-history for their therapeutic properties to treat a range of illnesses. These metabolites have recently attracted attention to their antineoplastic activities to treat various cancers relying on different mechanisms. Some of these molecules are glycosides, which have proven useful as anti-cancer agents, namely podophyllotoxin (PPT) anaryltetralin lignan or alkaloids. There are three primary forms of alkaloids, such as indole alkaloids (vincristine and vinblastine from Catharanthus roseus), quinoline alkaloid (camptothecin from Camptotheca acuminata), and diterpenoid alkaloid (taxol and it's analogous from Taxus and Corylus species). This review considers various plant biotechnology approaches used to enhance the production of these anticancer molecules in different species. In this regard, many in vitro culture techniques such as stimulation of suspension culture and hairy roots are being used to investigate the effects of plant growth regulators and elicitors on various explants., (Copyright © 2020 The Author(s). Published by Elsevier Masson SAS.. All rights reserved.)
- Published
- 2020
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