1. Effects of low ambient temperature on hemodynamics and oxygen dynamics in a porcine hemorrhagic shock model
- Author
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Xue-feng ZHANG, Cheng ZHANG, Guang-rong GAO, Hui-yong JIANG, Chen-guang LV, Bao-lei ZHANG, Ming-shuang XIE, Zhi-li ZHANG, and Li YU
- Subjects
lcsh:R5-920 ,blood gas analysis ,shock, hemorrhagic ,lcsh:R ,hemodynamic phenomena ,temperature ,lcsh:Medicine ,lcsh:Medicine (General) - Abstract
Objective To investigate the effects of low ambient temperature on hemodynamics and oxygen dynamics in a porcine hemorrhagic shock model. Methods Thirty-two healthy adult Bama miniature pigs were randomly divided into four groups (8 each): control (group C), shock under room temperature (22℃, group R), shock under low ambient temperature (–10℃, group L) and shock under normal body temperature (keep pulmonary arterial temperature ranged from 38.5 to 39.5℃, group N). The hemorrhagic shock model was reproduced by venous bleeding (40% of total blood volume), and the core temperature (pulmonary arterial temperature and rectal temperature), heart rate (HR), mean arterial pressure (MAP), pulmonary arterial pressure (PAP), pulmonary arterial wedge pressure (PAWP), central venous pressure (CVP), cardiac output (CO), hemoglobin (Hb), saturation of mixed venous blood (SvO2) and blood gas analysis were recorded before reproduction of shock and at different time points after hemorrhagic shock. The whole body oxygen delivery index (DO2I), oxygen uptake index (VO2I), and oxygen extraction ratio (O2ER) were calculated. Results Four pigs died in group N during the experiment, meanwhile, no pig died in other groups. The core temperature in group C, R and L decreased significantly compared with group N (P
- Published
- 2013