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Copyright of Journal of International Reproductive Health/Family Planning is the property of Editorial Board of the Journal of International Reproductive Health/Family Planning and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: To explore the relationship between the embryodynamic parameters using time-lapse system and the pregnancy outcomes, so as to establish a model of the optimal embryo selection. Methods: A total of 137 cycles with the time-lapse system (IVF/ICSI-ET cycle) were retrospectively analyzed from December 2016 to December 2017. The clinical data including basic information and pregnancy outcomes were collected. The morphokinetic parameters using the time -lapse system (t2、t3、t4、t5、t6、t7、t8、cc2、s2、cc3、s3) were compared between the implanted embryos and the unimplanted embryos. Based on those parameters related with embryo implantation, a multivariate classification model was developed. This model was then primarily verified. Results: ① Totally 171 embryos had one or more early abnormal division event, in which 16 were considered to be implantable, and then transplanted. There were 4 embryos implantated succesfully. ② There were no significant differences in all of 11 morphokinetic parameters between the implanted embryos and the unimplanted embryos (P>0.05).③Thet6(OR=1.462,95%CI:1.093-1.954, P=0.010)and t7 (OR=0.803,95%a:0.653-0.989, P=0.039) could be the best predictors of implantation. A classification model was developed with these two parameters combined with the exclusion standard of abnormal division event. The implantation rate was declined as the embryonic grade dropped. The area under the receiver operating characteristic curve (AUC) was 0.649 (95% CI: 0.528-0.770). Conclusions: Two of morphokinetic parameters (t6, t7) could be closely related to the implantation potential. We tried to develop an embryo selecting model with these two parameters combined with exclusion standard of abnormal division events. It is true that this model should be furtherly validated in our centers. [ABSTRACT FROM AUTHOR]

Copyright of Journal of International Reproductive Health/Family Planning is the property of Editorial Board of the Journal of International Reproductive Health/Family Planning and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Putrescine, a kind of diamine, widely exists in animal body and food. Putrescine plays a series of physiological and pathological roles by the interaction with DNA, RNA, ligands and membrane proteins. The level of putrescine is increased in the reproductive organs during pregnancy. It has been showed that putrescine is closely related to spermatogenesis, sperm movement, follicular development and ovulation. The effects of putrescine in aging women are included as follows: the reduced aneuploidy rate, the improved ooplasm maturation and oocytes antioxidant function. Putrescine is also related to the function of early placenta and the development of embryos, fetuses and infants. It is true that the level of putrescine must be regulated by dynamic equilibrium. If the level of putrescine exceed the certain range, or imbalanced, putrescine will be harmful. Although putrescine has been tried in the assisted reproductive process of animals, its safety is not clear enough. This paper outlines the safty, pharmacokinetics, genotoxicity and carcinogenicity of putrescine in the target organs, reproductive processes and embryo development, as a reference for the clinical trial of human natural and assisted reproduction in future. [ABSTRACT FROM AUTHOR]

Copyright of Journal of International Reproductive Health/Family Planning is the property of Editorial Board of the Journal of International Reproductive Health/Family Planning and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)