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Objective To evaluate the effect of center group pregnancy care mode on the outcome of delivery in elderly pregnant parturient for a second child. Methods A total of 100 pregnant (over 35 years old) women for a second child who established Obstetrical Outpatient Card and underwent regular checkup in our First Affiliated Hospital from March 2018 to March 2019 were recruited in this study. They were randomly divided into experimental group (n=50) and control group (n=50). For the experimental group, the participants accepted not only the prenatal clinic consultation but also subject course of center group pregnancy care mode, while the participants in the control group were given the traditional pregnancy care mode. Natural delivery rate, cesarean section rate, episiotomy rate, forceps delivery rate, postpartum hemorrhage rate in 2 h after delivery, labor time, Self-rating Anxiety Scale (SAS) and Self-rating Depression Scale (SDS) scores, and patient's satisfaction were compared between the 2 groups. Results Eventually, a total of 100 pregnant women completed this clinical trial. The experimental group had significantly higher natural delivery rate and patient's satisfaction, obviously lower cesarean section rate and episiotomy rate, shorter durations for the first, second and third stage of labor and for total labor, decreased postpartum hemorrhage rate, and reduced SAS and SDS scores when compared with the control group (P < 0.05). No significant difference was seen in the Apgar score between the babies of the 2 groups (P>0.05). Conclusion The center group pregnancy care mode can reduce the cesarean section rate, episiotomy rate and postpartum hemorrhage rate, shorten time for stage of labor, attenuate the postpartum anxiety and depression, and improve natural childbirth rate and patient's satisfaction.