1. [Chief cell mass in gastric ulcer: cyto-secretory correlations].
- Author
-
Perasso A and Testino G
- Subjects
- Adult, Aged, Aminosalicylic Acid, Biopsy, Enzyme Precursors analysis, Female, Gastric Fundus pathology, Gastric Mucosa pathology, Gastritis blood, Gastritis pathology, Humans, Immunohistochemistry, Male, Middle Aged, Parietal Cells, Gastric, Stomach Ulcer blood, Gastric Acid metabolism, Pepsinogens blood, Stomach Ulcer pathology
- Abstract
The aim of this experience has been to evaluate the chief cell mass and serum pepsinogen I in gastric ulcer patients. Comparisons were also made with parietal cell mass and acid secretion. Chief cell mass and serum pepsinogen I are not only influenced by the localization of ulcer but, also, by the histological condition of fundic mucosa. In fact, the behaviour of serum pepsinogen I and chief cell mass in type I gastric ulcer is the same observed in case of fundic chronic gastritis without gastric ulcer. In case of gastric ulcer type I with superficial fundic gastritis it emerges normozymogenism with hyperpepsinogenemia++ I, with preatrophic fundic gastritis hypozymogenism with normopepsinogenemia, with atrophic fundic gastritis hypozymogenism with hypopepsinogenemia I. In type II and III gastric ulcer the chief cell mass and serum pepsinogen I behaviour as they do in duodenal ulcer with hyperpepsinogenemia although hypozymogenism is present.
- Published
- 1992