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In this report we discuss the case of a 55-year-old female who underwent echocardiographic and Doppler studies for the presence of systolic murmur at physical examination, in which echocardiography showed the concomitant presence of an atrial septal aneurysm, a Chiari network and a tricuspid valve prolapse, a hypothetic association not previously described. The association of atrial septal aneurysm, tricuspid valve prolapse and Chiari network suggests the possibility of a connective disorder involving fibrous tissue of the heart and a concomitant anomalous development of the valves of the sinus venosus.

The aim of our study is to detect morphological and functional aspects of left ventricle with noninvasive M-B-Mode echocardiography in acromegalic patients (pz) with and without high blood pressure. We studied 19 acromegalic pz (group A) and 19 normal pz (group N). All subjects were evaluated for the following parameters: left ventricular mass index (MI); end diastolic volume index (EDVI); end systolic volume index (ESVI); ejection fraction (EF); end systolic stress (ESS). Group A vs group N shows an increase of cardiac mass (p less than 0.01), of EDVI (p less than 0.05) and of ESS (p less than 0.05). We found the asymmetrical septal hypertrophy, considered from other Authors one of the more evident markers of acromegaly, in only one patient. In conclusion, the acromegalic pz show an increase of cardiac mass and preload and a reduced capacity of adaptation to afterload variation independently of blood pressure values and of the duration of disease, even if they have normal indexes of global systolic function.