1. [The biological complexity of Polycomb group proteins: the case of EZH2].
- Author
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Koubi M, Chabannon C, and Duprez E
- Subjects
- Animals, Cell Differentiation genetics, Cell Proliferation genetics, Gene Expression Regulation, Gene Regulatory Networks genetics, Genes, Tumor Suppressor, Humans, Oncogenes physiology, Signal Transduction genetics, Enhancer of Zeste Homolog 2 Protein physiology, Polycomb-Group Proteins physiology
- Abstract
Polycomb Group proteins (PcG) are repressive epigenetic factors essential for development and involved in numerous cancer processes, yet their modes of action and recruitment to specific genomic loci are not fully understood. Recently, it has been shown that the PcG protein recruitment is a dynamic process, contrary to what was foreseen in the initial hierarchical model. In addition, EZH2, a key PcG protein, can be associated to transcribed genes, challenging the former function of PcG proteins as transcriptional repressors. Furthermore, the dual role of EZH2, which can act as an oncogene or a tumor suppressor depending on the cellular type, illustrates the functional complexity of PcG proteins., (© 2017 médecine/sciences – Inserm.)
- Published
- 2017
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