11 results
Search Results
2. Reaction-Diffusion Modelling of Interferon Distribution in Secondary Lymphoid Organs.
- Author
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Bocharov, G., Danilov, A., Vassilevski, Yu., Marchuk, G.I., Chereshnev, V.A., and Ludewig, B.
- Subjects
REACTION-diffusion equations ,INTERFERONS ,LYMPHOID tissue ,LYMPH nodes ,NUMERICAL grid generation (Numerical analysis) - Abstract
This paper proposes a quantitative model of the reaction-diffusion type to examine the distribution of interferon-α (IFNα) in a lymph node (LN). The numerical treatment of the model is based on using an original unstructured mesh generation software Ani3D and nonlinear finite volume method for diffusion equations. The study results in suggestion that due to the variations in hydraulic conductivity of various zones of the secondary lymphoid organs the spatial stationary distribution of IFNα is essentially heterogeneous across the organs. Highly protected domains such as sinuses, conduits, co-exist with the regions in which where the stationary concentration of IFNα is lower by about 100-fold. This is the first study where the spatial distribution of soluble immune factors in secondary lymphoid organs is modelled for a realistic three-dimensional geometry. [ABSTRACT FROM PUBLISHER]
- Published
- 2011
- Full Text
- View/download PDF
3. Global Existence of Periodic Solutions in a Delayed Tumor-Immune Model.
- Author
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Taik, A., Kaddar, A., and Talibi Alaoui, H.
- Subjects
CELL tumors ,IMMUNE response ,CELLULAR immunity ,TUMOR growth ,DIFFERENTIAL equations ,HOPF bifurcations - Abstract
This paper is devoted to the study of global existence of periodic solutions of a delayed tumor-immune competition model. Also some numerical simulations are given to illustrate the theoretical results [ABSTRACT FROM PUBLISHER]
- Published
- 2010
- Full Text
- View/download PDF
4. Global Asymptotic Stability of Equilibria in Models for Virus Dynamics.
- Author
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Prüssa, J., Zacher, R., and Schnaubelt, R.
- Subjects
EQUILIBRIUM ,MATHEMATICAL models ,VIRUSES ,IMMUNE response ,T cells - Abstract
In this paper several models in virus dynamics with and without immune response are discussed concerning asymptotic behaviour. The case of immobile cells but diffusing viruses and T-cells is included. It is shown that, depending on the value of the basic reproductive number R
0 of the virus, the corresponding equilibrium is globally asymptotically stable. If R0 < 1 then the virus-free equilibrium has this property, and in case R0 > 1 there is a unique disease equilibrium which takes over this property.. [ABSTRACT FROM AUTHOR]- Published
- 2008
5. A fractional diffusion model of CD8+ T cells response to parasitic infection in the brain.
- Author
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FARHADI, AFSHIN and HANERT, EMMANUEL
- Subjects
PARASITIC diseases ,T cells ,LEVY processes ,FETAL diseases ,CELL motility ,HEAT equation ,EXTRACELLULAR space ,FETUS - Abstract
Toxoplasma gondii (T. gondii) is a parasitic pathogen that causes serious brain diseases in fetuses and patients with immunodeficiency, particularly AIDS patients. In the field of immunology, a large number of studies have shown that effector CD8
+ T cells can respond to T. gondii infection in the brain tissue through controlling the proliferation of intracellular parasites and killing infected brain cells. These protective mechanisms do not occur without T cell movement and searching for infected cells, as a fundamental feature of the immune system. Following infection with a pathogen in a tissue, in their search for infected cells, CD8+ T cells can perform different stochastic searches, including Lévy and Brownian random walks. Statistical analysis of CD8+ T cell movement in the brain of T. gondii-infected mouse has determined that the search strategy of CD8+ T cells in response to infected brain cells could be described by a Lévy random walk. In this work, by considering a Lévy distribution for the displacements, we propose a space fractional-order diffusion equation for the T cell density in the infected brain tissue. Furthermore, we derive a mathematical model representing CD8+ T cell response to infected brain cells. By solving the model equations numerically, we perform a comparison between Lévy and Brownian search strategies. we demonstrate that the Lévy search pattern enables CD8+ T cells to spread over the whole brain tissue and hence they can rapidly destroy infected cells distributed throughout the brain tissue. However, with the Brownian motion assumption, CD8+ T cells travel through the brain tissue more slowly, leading to a slower decline of the infected cells faraway from the source of T cells. Our results show that a Lévy search pattern aids CD8+ T cells in accelerating the elimination of infected cells distributed broadly within the brain tissue. We suggest that a Lévy search strategy could be the result of natural evolution, as CD8+ T cells learn to enhance the immune system efficiency against pathogens. [ABSTRACT FROM AUTHOR]- Published
- 2022
- Full Text
- View/download PDF
6. Aphtose de Bednar : une étiologie incertaine.
- Author
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Glock, Nicolas and Fricain, Jean-Christophe
- Subjects
PALATE ,ULCERS ,INFANT diseases ,IMMUNE response ,APPETITE loss ,DISEASES - Abstract
Copyright of Médecine Buccale Chirurgie Buccale is the property of EDP Sciences and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2013
- Full Text
- View/download PDF
7. Dynamics of a Stochastic Viral Infection Model with Immune Response.
- Author
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Mahrouf, M., Hattaf, K., and Yousfi, N.
- Subjects
IMMUNE response ,VIRUS diseases ,STOCHASTIC differential equations ,INFECTIOUS disease transmission ,INFECTION - Abstract
The aim of this work is to study the dynamical behavior of a stochastic viral infection model which is formulated by four nonlinear stochastic differential equations to describe the interactions between virus, host cells, and immune response represented by cytotoxic T lymphocytes (CTL) cells. The infection transmission process is modeled by Hattaf-Yousfi incidence function which includes many special cases existing in the literature. The positivity of solutions is investigated. In addition, the extinction of the infection is established in terms of the basic reproduction number R
0 . Moreover, sufficient conditions for the fluctuation of solutions around the two infection equilibria are obtained. Numerical simulations are presented to illustrate our theoretical results. [ABSTRACT FROM AUTHOR]- Published
- 2017
- Full Text
- View/download PDF
8. On HIV Model with Adaptive Immune Response, Two Saturated Rates and Therapy.
- Author
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Allali, K., Tabit, Y., and Harroudi, S.
- Subjects
IMMUNE response ,HIV-positive persons ,T cells ,MATHEMATICAL models ,VIRUS diseases ,THERAPEUTICS - Abstract
The mathematical model of the human immunodeficiency virus (HIV) pathogenesis with the adaptive immune response, two saturated rates and therapy is presented and studied in this work. The adaptive immune response is represented by the cytotoxic T-lymphocytes (CTL) cells and the antibodies; the two saturated rates describe the viral infection and the CTL proliferation. Two kinds of treatments are incorporated into the model; the objective of the first one is to reduce the number of infected cells, while the aim of the second one is to block the free viruses. The positivity and boundedness of solutions are established. The local stability of the disease free steady state and the infection steady states are studied. Numerical simulations are performed to show the behavior of solutions and the effectiveness of the incorporated therapy in controlling the HIV replication which can improves significantly the patient's life quality. [ABSTRACT FROM AUTHOR]
- Published
- 2017
- Full Text
- View/download PDF
9. The sera from individuals suffering from cutaneous leishmaniasis due to Leishmania braziliensis present antibodies against parasitic conserved proteins, but not their human counterparts
- Author
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Carmelo E., Zurita A.I., Martinez E., and Valladares B.
- Subjects
autoimmunity ,immune response ,histone ,chaperone ,Leishmania braziliensis ,Infectious and parasitic diseases ,RC109-216 - Abstract
Sera from individuals suffering from leishmaniasis have been shown to strongly react against conserved proteins from the parasite, such as ribosomal, histones and heat-shock proteins. Some of these proteins have also been described as immunogenic in several auto-immune syndromes, and the detection of antibodies against them is considered to be indicative of disorder of the immune system. In this paper, we investigate whether there is any relationship between the recognition of some conserved proteins from Leishmania braziliensis by individuals suffering from cutaneous (CL) and mucocutaneous (MCL) leishmaniasis, and the recognition of the human homologues of these antigens found in sufferers from autoimmune diseases. Our findings reveal that the immune response generated during CL and MCL is elicited specifically by the parasitic histone H1 and Hsp70, since the CL and MCL sera do not react against their human counterparts. In addition, evidence is presented showing the specific recognition of human proteins by the autoimmune sera, showing only a weak crossreaction with the most divergent regions of the parasitic proteins.
- Published
- 2006
- Full Text
- View/download PDF
10. Haemonchotolerance in West African Dwarf goats: contribution to sustainable, anthelmintics-free helminth control in traditionally managed Nigerian dwarf goats.
- Author
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Chiejina, Samuel N., Behnke, Jerzy M., and Fakae, Barineme B.
- Subjects
PYGMY goat ,HELMINTHS ,PARASITES ,NIGERIAN dwarf goat ,TRYPANOTOLERANCE ,IMMUNE response - Abstract
Copyright of Parasite (1252607X) is the property of EDP Sciences and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2015
- Full Text
- View/download PDF
11. Mathematical Modelling of Tumour Dormancy.
- Author
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Page, K. M.
- Subjects
CANCER cells ,IMMUNE response ,TUMOR surgery ,TUMOR growth ,BREAST cancer ,MATHEMATICAL models - Abstract
Many tumours undergo periods in which they apparently do not grow but remain at a roughly constant size for extended periods. This is termed tumour dormancy. The mechanisms responsible for dormancy include failure to develop an internal blood supply, individual tumour cells exiting the cell cycle and a balance between the tumour and the immune response to it. Tumour dormancy is of considerable importance in the natural history of cancer. In many cancers, and in particular in breast cancer, recurrence can occur many years after surgery to remove the primary tumour, following a long period of occult disease. Mathematical modelling suggested that continuous growth of tumours was incompatible with data of the times of recurrence in breast cancer, suggesting that tumour dormancy was a common phenomenon. Modelling has also been applied to understanding the mechanisms responsible for dormancy, how they can be manipulated and the implications for cancer therapy. Here, the literature on mathematical modelling of tumour dormancy is reviewed. In conclusion, promising future directions for research are discussed. [ABSTRACT FROM AUTHOR]
- Published
- 2009
- Full Text
- View/download PDF
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