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Circulatory stability of patients with cerebrovascular malformations during the surgery is critical to their prognosis. Anesthesia-induced intubation, tumor separation, clamping and other operations may cause severe fluctuations in blood pressure and even result in aneurysm rupture. As a highly efficient and selective adrenergic α2 receptor agonists, dexmedetomidine hydrochloride is able to regulate the release of catecholamine by means of negative feedback so as to control blood pressure. This study aims to assess the effects of dexmedetomidine hydrochloride on hemodynamics and cerebral oxygen metabolism of intraoperative patients with cerebrovascular malformations.

Objective: To compare effects of desflurane and sevoflurane on cognitive function in elderly patients undergoing general anesthesia. Methods Eighty elderly patients undergoing general anesthesia under open surgery were enrolled in this study, ASA I ~ II, were divided into group A (desflurane group) and group B (sevoflurane group) randomly. Intravenous drugs included midazolam 0.03 mg / kg, sufentanil 0.5ug / kg, propofol 1-2mg / kg, vecuronium 0.1 mg / kg. All patients were treated with desflurane or sevoflurane to maintain anesthesia, with depth 1.2 ~ 1.4MAC. The mini-mental state examination (MMSE) scores were recorded before operation and 1h, 6h, 12h, 24h and 48h after operation. Results The MMSE scores of the two groups had no significant difference before operation but were significantly lower than those before operation (P

Objective: To investigate the efficacy of a single intravenous injection of oxycodone hydrochloride in patients undergoing laparoscopic rectal tumor resection with acute postoperative pain and evaluate the quality of Anesthesia recovery period. Methods: 60 patients for laparoscopic rectal tumor resection, were randomly divided into two groups (n=30 each): oxycodone hydrochloride injection group (group I) and fentanil injection group (group II). oxycodone 0.05mg / kg (saline dilution of 1mg / ml) or fentanil 0.1ug / kg was injected intravenously at the end of surgery. Assessing the OAA / S sedation grade and Prince-Henry postoperative pain scores. Results: Demographic data and anesthesia characteristics were similar in the two groups. Group II’s Prince-Henry pain score was significantly higher than the group I’s (P