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Your search keyword '"Wahid Doss"' showing total 5 results
Start Over Author "Wahid Doss" Publisher egypts presidential specialized council for education and scientific research
5 results on '"Wahid Doss"'

3. Interleukin 28b Single Nucleotide Polymorphism (rs8099917) as a Predictive Factor of Response to Pegylated-IFN/Ribavirintherapy in Chronic HCV Patients

Author

Mohammad El-Sayed, Wahid Doss, Mohamed Ali Saber, Ahmed El Deeb, and Gamal Esmat

Subjects
medicine.medical_specialty, business.industry, Ribavirin, virus diseases, Alpha (ethology), Single-nucleotide polymorphism, Gastroenterology, digestive system diseases, chemistry.chemical_compound, Interleukin 28B, chemistry, Pegylated interferon, Internal medicine, Genotype, medicine, SNP, Risk factor, business, medicine.drug
Abstract

Background: For Interleukin 28b Single nucleotide poly-morphism (SNP) rs8099917, the favourable T allele is asso-ciated with a higher SVR after PEG-IFN alpha/RBV therapy while the G allele is a risk factor for non-response. Aim of Study: To assess the value of Interleukin 28b (SNP) rs8099917 as a predictor of SVR. Patients and Methods: This study is a retrospective con-trolled study and was performed on a total number of 240 patients who were treated by PEG-IFN alpha/RBV for 48 weeks and (SNP) rs8099917 was done for the all patients. Results: TT genotype was more prevalent in SVR group than TG and GG genotypes. Conclusion: IL-28b single nucleotide polymorphism (SNP) rs8099917 is a strong pretreatment predictor of response to pegylated interferon and ribavirin therapy in egyptian patients chronically infected with HCV genotype 4.

Published
2021

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