1. The Human Cell Atlas
- Author
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Seung K. Kim, Mihai G. Netea, Partha P. Majumder, Muzlifah Haniffa, Padmanee Sharma, Sten Linnarsson, Roland Eils, Human Cell Atlas Meeting Participants, Matthias Uhlen, Allon Wagner, James Eberwine, Fiona M. Watt, Ehud Shapiro, Orit Rozenblatt-Rosen, Peter J. Campbell, Garry P. Nolan, Nir Hacohen, Dana Pe'er, Ed S. Lein, Lars Fugger, Bart Deplancke, Ido Amit, Alexander van Oudenaarden, Wolfgang Enard, Barbara J. Wold, Anthony Phillipakis, Martin Hemberg, Wolf Reik, Chris P. Ponting, Paul Klenerman, Andrew Farmer, Emma Lundberg, Bernd Bodenmiller, Fabian J. Theis, Alex K. Shalek, Aviv Regev, Arnold R. Kriegstein, Eric S. Lander, Nir Yosef, Michael J. T. Stubbington, Christophe Benoist, Ton N. Schumacher, Musa M. Mhlanga, Rahul Satija, Ewan Birney, Stephen R. Quake, John C. Marioni, Jonathan S. Weissman, Hans Clevers, Oliver Stegle, Sarah A. Teichmann, Menna R. Clatworthy, Jay W. Shin, Miriam Merad, Ramnik J. Xavier, Joshua R. Sanes, Martijn C. Nawijn, Michael R. Stratton, Berthold Göttgens, Joakim Lundeberg, Ian Dunham, Piero Carninci, Massachusetts Institute of Technology. Department of Biology, Regev, Aviv, Lander, Eric Steven, Regev, Aviv [0000-0003-3293-3158], Carninci, Piero [0000-0001-7202-7243], Deplancke, Bart [0000-0001-9935-843X], Enard, Wolfgang [0000-0002-4056-0550], Göttgens, Berthold [0000-0001-6302-5705], Haniffa, Muzlifah [0000-0002-3927-2084], Lein, Ed [0000-0001-9012-6552], Ponting, Chris P [0000-0003-0202-7816], Sanes, Joshua [0000-0001-8926-8836], Satija, Rahul [0000-0001-9448-8833], Watt, Fiona [0000-0001-9151-5154], Weissman, Jonathan [0000-0003-2445-670X], Yosef, Nir [0000-0001-9004-1225], Apollo - University of Cambridge Repository, and Hubrecht Institute for Developmental Biology and Stem Cell Research
- Subjects
0301 basic medicine ,International Cooperation ,Bioinformatics ,0302 clinical medicine ,Human disease ,computational biology ,Stem Cell Research - Nonembryonic - Human ,cell biology ,Profiling (information science) ,2.1 Biological and endogenous factors ,Aetiology ,Biology (General) ,Human Body ,single-cell genomics ,General Neuroscience ,systems biology ,General Medicine ,Human cell ,Open data ,Eukaryotic Cells ,Medicine ,cell atlas ,Computational and Systems Biology ,Cell type ,QH301-705.5 ,Systems biology ,1.1 Normal biological development and functioning ,Science ,Computational biology ,Biology ,Human Cell Atlas Meeting Participants ,General Biochemistry, Genetics and Molecular Biology ,03 medical and health sciences ,Atlases as Topic ,SDG 3 - Good Health and Well-being ,Underpinning research ,Genetics ,Humans ,human ,mouse ,General Immunology and Microbiology ,Feature Article ,Human Genome ,Human body ,Stem Cell Research ,Embryonic stem cell ,science forum ,030104 developmental biology ,Generic health relevance ,Biochemistry and Cell Biology ,030217 neurology & neurosurgery ,lineage - Abstract
The recent advent of methods for high-throughput single-cell molecular profiling has catalyzed a growing sense in the scientific community that the time is ripe to complete the 150-year-old effort to identify all cell types in the human body. The Human Cell Atlas Project is an international collaborative effort that aims to define all human cell types in terms of distinctive molecular profiles (such as gene expression profiles) and to connect this information with classical cellular descriptions (such as location and morphology). An open comprehensive reference map of the molecular state of cells in healthy human tissues would propel the systematic study of physiological states, developmental trajectories, regulatory circuitry and interactions of cells, and also provide a framework for understanding cellular dysregulation in human disease. Here we describe the idea, its potential utility, early proofs-of-concept, and some design considerations for the Human Cell Atlas, including a commitment to open data, code, and community.
- Published
- 2018
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