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Your search keyword '"Marina Cardó-Vila"' showing total 2 results
Start Over Author "Marina Cardó-Vila" Publisher elife sciences publications ltd
2 results on '"Marina Cardó-Vila"'

1. Targeting a cell surface vitamin D receptor on tumor-associated macrophages in triple-negative breast cancer

Author

Fernanda I Staquicini, Amin Hajitou, Wouter HP Driessen, Bettina Proneth, Marina Cardó-Vila, Daniela I Staquicini, Christopher Markosian, Maria Hoh, Mauro Cortez, Anupama Hooda-Nehra, Mohammed Jaloudi, Israel T Silva, Jaqueline Buttura, Diana N Nunes, Emmanuel Dias-Neto, Bedrich Eckhardt, Javier Ruiz-Ramírez, Prashant Dogra, Zhihui Wang, Vittorio Cristini, Martin Trepel, Robin Anderson, Richard L Sidman, Juri G Gelovani, Massimo Cristofanilli, Gabriel N Hortobagyi, Zaver M Bhujwalla, Stephen K Burley, Wadih Arap, and Renata Pasqualini

Subjects
vitamin D receptor, tumor-associated macrophage, triple-negative breast cancer, Medicine, Science, Biology (General), QH301-705.5
Abstract

Triple-negative breast cancer (TNBC) is an aggressive tumor with limited treatment options and poor prognosis. We applied the in vivo phage display technology to isolate peptides homing to the immunosuppressive cellular microenvironment of TNBC as a strategy for non-malignant target discovery. We identified a cyclic peptide (CSSTRESAC) that specifically binds to a vitamin D receptor, protein disulfide-isomerase A3 (PDIA3) expressed on the cell surface of tumor-associated macrophages (TAM), and targets breast cancer in syngeneic TNBC, non-TNBC xenograft, and transgenic mouse models. Systemic administration of CSSTRESAC to TNBC-bearing mice shifted the cytokine profile toward an antitumor immune response and delayed tumor growth. Moreover, CSSTRESAC enabled ligand-directed theranostic delivery to tumors and a mathematical model confirmed our experimental findings. Finally, in silico analysis showed PDIA3-expressing TAM in TNBC patients. This work uncovers a functional interplay between a cell surface vitamin D receptor in TAM and antitumor immune response that could be therapeutically exploited.

Published
2021
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2. Targeting a cell surface vitamin D receptor on tumor-associated macrophages in triple-negative breast cancer

Author

Wouter H. P. Driessen, Anupama Hooda-Nehra, Wadih Arap, Prashant Dogra, Massimo Cristofanilli, Diana N. Nunes, Vittorio Cristini, Emmanuel Dias-Neto, Martin Trepel, Javier Ruiz-Ramírez, Robin L. Anderson, Fernanda I. Staquicini, Zhihui Wang, Marina Cardó-Vila, Gabriel Hortobagy, Juri G. Gelovani, Zaver M. Bhujwalla, Stephen K. Burley, Daniela I. Staquicini, Mauro Cortez, Amin Hajitou, Renata Pasqualini, Bettina Proneth, Maria Hoh, Richard L. Sidman, Mohammed Jaloudi, Bedrich L. Eckhardt, Israel Tojal da Silva, Jaqueline Ramalho Buttura, and Christopher Markosian

Subjects
0301 basic medicine, Mouse, Cell, Triple Negative Breast Neoplasms, PDIA3, Ligands, Calcitriol receptor, tumor-associated macrophage, 0302 clinical medicine, Tumor-Associated Macrophages, Tumor Microenvironment, Biology (General), Triple-negative breast cancer, Mice, Inbred BALB C, Vitamin D-Binding Protein, General Neuroscience, General Medicine, Tumor Burden, Gene Expression Regulation, Neoplastic, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Systemic administration, triple-negative breast cancer, Medicine, Female, Oligopeptides, Research Article, Signal Transduction, QH301-705.5, Science, Protein Disulfide-Isomerases, Mice, Nude, Antineoplastic Agents, Tumor-associated macrophage, Models, Biological, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, Immune system, Breast cancer, FÁRMACOS IMUNOSSUPRESSORES, Cell Line, Tumor, medicine, Animals, Humans, vitamin D receptor, ddc:610, General Immunology and Microbiology, business.industry, medicine.disease, Xenograft Model Antitumor Assays, Triple-negative Breast Cancer, Tumor-associated Macrophage, Vitamin D Receptor, Enzyme Activation, 030104 developmental biology, Cancer research, business
Abstract

Triple-negative breast cancer (TNBC) is an aggressive tumor with limited treatment options and poor prognosis. We applied the in vivo phage display technology to isolate peptides homing to the immunosuppressive cellular microenvironment of TNBC as a strategy for non-malignant target discovery. We identified a cyclic peptide (CSSTRESAC) that specifically binds to a vitamin D receptor, protein disulfide-isomerase A3 (PDIA3) expressed on the cell surface of tumor-associated macrophages (TAM), and targets breast cancer in syngeneic TNBC, non-TNBC xenograft, and transgenic mouse models. Systemic administration of CSSTRESAC to TNBC-bearing mice shifted the cytokine profile toward an antitumor immune response and delayed tumor growth. Moreover, CSSTRESAC enabled ligand-directed theranostic delivery to tumors and a mathematical model confirmed our experimental findings. Finally, in silico analysis showed PDIA3-expressing TAM in TNBC patients. This work uncovers a functional interplay between a cell surface vitamin D receptor in TAM and antitumor immune response that could be therapeutically exploited.

Published
2021

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