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Purpose: To report 2 cases of atypically located, non-nasal colobomas in the pediatric population., Observations: A 3-week-old female neonate with no known past ocular or medical history was diagnosed with temporal iris and chorioretinal coloboma with tractional membranes upon examination under anesthesia and imaging. A 9-year-old female with a history of bilateral sensorineural hearing loss and left mild hydronephrosis presented with a temporal chorioretinal coloboma associated with retinal detachment., Conclusions and Importance: Very few cases of atypically located, non-nasal pediatric colobomas have been reported, and they lack a clear cause or mechanism of formation. Continued documentation of their occurrence and research into their formation at a molecular and embryological level are warranted to better understand their pathogenesis., Competing Interests: Financial Support: Research supported in part by an unrestricted grant from 10.13039/100001818Research to Prevent Blindness (New York, New York), NIH Center Core Grant P30EY014801 (Bethesda, Maryland), 10.13039/100000005Department of Defense (DOG Grant #W81XWH-09-1-0675) (Washington, D.C.), 2022 10.13039/100006325ARVO Foundation for Eye Research and EyeFind Research Grant, 2022 10.13039/100001818Research to Prevent Blindness/Bascom Palmer Eye Institute Pilot Grant, and 2021 10.13039/100001818RPB/10.13039/100011603AAO Award for 10.13039/501100013945IRIS Registry Research. The sponsor or funding organization had no role in the design or conduct of this study., (© 2024 The Authors. Published by Elsevier Inc.)