1. Decreased platelet [3H]paroxetine binding sites in suicide attempters.
- Author
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Marazziti D, Dell'Osso L, Rossi A, Masala I, Baroni S, Armani A, Giannaccini G, Di Nasso E, Lucacchini A, and Cassano GB
- Subjects
- Adolescent, Adult, Bipolar Disorder physiopathology, Bipolar Disorder psychology, Comorbidity, Depressive Disorder physiopathology, Depressive Disorder psychology, Female, Humans, Male, Mental Disorders physiopathology, Mental Disorders psychology, Middle Aged, Paroxetine pharmacokinetics, Radioligand Assay, Risk Factors, Serotonin Plasma Membrane Transport Proteins, Carrier Proteins blood, Carrier Proteins physiology, Receptors, Drug blood, Suicide, Attempted psychology
- Abstract
Research to date would suggest the possible involvement of the serotonin (5-HT) system in the pathophysiology of suicide. With this study, we aimed to investigate the platelet 5-HT transporter, by means of the specific binding of tritiated paroxetine ([3H]Par), in a sample of 20 suicide attempters recruited at a first-aid service, as compared with healthy control subjects and psychiatric patients with no current or previous history of suicide attempt. The results, showing a decreased number of [3H]Par binding sites in suicide attempters, would suggest the involvement of the presynaptic 5-HT transporter in self-aggressive behavior.
- Published
- 2001
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