1. αCaMKII autophosphorylation controls the establishment of alcohol-induced conditioned place preference in mice.
- Author
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Easton AC, Lucchesi W, Mizuno K, Fernandes C, Schumann G, Giese KP, and Müller CP
- Subjects
- Analysis of Variance, Animals, Behavior, Addictive physiopathology, Calcium-Calmodulin-Dependent Protein Kinase Type 2 deficiency, Extinction, Psychological drug effects, Female, Locomotion drug effects, Locomotion genetics, Male, Mice, Mice, Knockout, Phosphorylation, Calcium-Calmodulin-Dependent Protein Kinase Type 2 metabolism, Central Nervous System Depressants pharmacology, Conditioning, Operant drug effects, Ethanol pharmacology
- Abstract
The autophosphorylation of alpha Ca2+ /calmodulin dependent protein kinase II (αCaMKII) is important for memory formation and is becoming increasingly implicated in the development of drug addiction. Previous work suggests that αCaMKII acts via the monoaminergic systems to facilitate the establishment of alcohol drinking behaviour. The present study aims to investigate whether αCaMKII autophosphorylation deficient αCaMKII(T286A) mice show a difference in the rewarding properties of alcohol (2 g/kg, i.p.), as measured by conditioned place preference (CPP). We found that alcohol-induced CPP could be established at an accelerated rate in αCaMKII(T286A) compared to wild type (WT) mice. Hyperactivity/hyper-arousal induced by the test environment was normalised by alcohol in the αCaMKII(T286A), but not WT mice. This effect could be conditioned to the test environment and may suggest enhanced negative reinforcing action of alcohol in αCaMKII autophosphorylation deficient mice., (Copyright © 2013 Elsevier B.V. All rights reserved.)
- Published
- 2013
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