42 results on '"A., Jesu"'
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2. Corrigendum to 'A synthetic antioxidant molecule, GP13 derived from cysteine desulfurase of spirulina, Arthrospira platensis exhibited anti-diabetic activity on L6 rat skeletal muscle cells through GLUT-4 pathway' [J. King Saud Univ. – Sci. 35(2) (2023) 102450]
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Purabi Sarkar, Stefi V. Raju, Manikandan Velayutham, Ajay Guru, Mukesh Pasupuleti, Ebtesam M. Al Olayan, Amy F. Boushra, Annie Juliet, and Jesu Arockiaraj
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Science (General) ,Q1-390 - Published
- 2024
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3. Corrigendum to 'Antibiofilm efficacy of novel biogenic silver nanoparticles from Terminalia catappa against food-borne Listeria monocytogenes ATCC 15,313 and mechanisms investigation in-vivo and in-vitro' [J. King Saud Univ. – Sci. 34(5) (2022) 102083]
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Lakshmanan Muthulakshmi, Kannan Suganya, Maruthamuthu Murugan, Jamespandi Annaraj, Veeramuthu Duraipandiyan, Dunia A. Al Farraj, Mohamed S. Elshikh, Annie Juliet, Mukesh Pasupuleti, and Jesu Arockiaraj
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Science (General) ,Q1-390 - Published
- 2024
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4. Contributors
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Abbas, Manzar, primary, Ahmad, Jalal, additional, Akhtar, Mahmood Hassan, additional, Andleeb, Farah, additional, Arockiaraj, Jesu, additional, Atiq, Atia, additional, Atiq, Maria, additional, Banerjee, Jhimli, additional, Bao, Jianwei, additional, Bukhari, Syeda Zunaira, additional, Dash, Sandeep Kumar, additional, Hussain, Sajid, additional, Idrees, Sana, additional, Iftikhar, Maryam, additional, Ihsan, Ayesha, additional, Ijaz, Shumaila, additional, Iqbal, Javed, additional, Irshad, Kanwal, additional, Khalil, Ali Talha, additional, Khan, Hasan. M., additional, Manjusha, Muralidharan, additional, Mir, Tanveer Ahmad, additional, Mukherjee, Sudip, additional, Ovais, Muhammad, additional, Pramanik, Arindam, additional, Rafiq, Farhat, additional, Saleem, Muhammad, additional, Samanta, Sovan, additional, Saravanan, Muthupandian, additional, Shabbir, Maryam, additional, Shahid, Syed Ahsan, additional, Sravanthy, Geetha, additional, Tabish, Tanveer A., additional, Ullah, Sana, additional, Vydiam, Kalyan, additional, Yasasve, Madhavan, additional, Younas, Maira, additional, Younis, Muhammad Rizwan, additional, Yu, Cong, additional, Zou, Qianli, additional, khan, Maroof Ahmad, additional, and UR Rehman, Saeed, additional
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- 2024
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5. Fabrication of polymeric nanomaterials for phototheranostics of cancer
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Manjusha, Muralidharan, primary, Yasasve, Madhavan, additional, Sravanthy, Geetha, additional, Arockiaraj, Jesu, additional, and Saravanan, Muthupandian, additional
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- 2024
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6. Imidazooxazine moiety as polyketide synthase 13 inhibitors targeting tuberculosis
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B. Shanthakumar, P. Gopinath, Bharath Kumar Chagaleti, Venkatesan Saravanan, Senthil Kumar Palaniappan, Saeedah Musaed Almutairi, Dina S. Hussein, Yasmine Hamdy Eisa, M.K. Kathiravan, and Jesu Arockiaraj
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Antimicrobial resistance ,Tuberculosis ,Antimycobacterial ,Polyketide synthase ,Thioesterase ,Imidazo [2,1-b] [1,3] oxazine ,Science (General) ,Q1-390 - Abstract
Introduction: Recently, imidazooxazines have attracted more attention due to their therapeutic potential against tuberculosis (TB). The present study aimed to identify and develop potential inhibitors against Pks13-TE to combat the antimicrobial drug resistance of TB. Methods: Computer-aided drug design is a more highly valued technology than the traditional drug discovery approach. Herein, we computationally investigated a chemical dataset using QSAR models and virtually screened novel leads of imidazooxazines against the thioesterase domain, further subjecting them to molecular docking and dynamics simulation. Results: The present study identified two molecules, 1 and 3, promising leads with minimum energy conformations of −7.63 and −7.62 kcal, respectively, providing structural insight into Pks13 inhibition. The average values of MolSA, SASA, and PSA for molecules 1 and 3 were 382.41 Å, 77.65 Å, and 195.54 Å and 386.24 Å, 71.105 Å, and 184.46 Å, respectively. In conclusion, our research has demonstrated that imidazoxazines are promising leads to combat the resistance problem of TB. Among the two potent molecules 1 and 3, molecule 1 displayed favourable interactions in the active site with good stability, as confirmed by the RMSD, RMSF, RoG, H-bond, and SASA analyses. The Molecule 1 protein complex showed two strong hydrogen bonds, effectively maintained for 80–85 % of the simulation time, indicating its stability and potency. Conclusion: The identified two molecules and their conformations were highly stable; hence, these findings provide valuable insight into the evolution of new therapeutic agents to address the growing problem of TB and its resistance.
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- 2024
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7. Evaluating the fillet quality and sensory characteristics of Atlantic salmon (Salmo salar) fed black soldier fly larvae meal for whole production cycle in sea cages
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Gopika Radhakrishnan, Antony Jesu Prabhu Philip, Christian Caimi, Erik-Jan Lock, Pedro Araujo, Nina S. Liland, Celia Rocha, Luís Miguel Cunha, Laura Gasco, and Ikram Belghit
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Insect meal ,Large-scale trial ,Product quality ,Sustainable feed ingredient ,Aquaculture. Fisheries. Angling ,SH1-691 - Abstract
There is scarce research on the use of black soldier fly larvae (BSFL) meal in the diets of Atlantic salmon (Salmo salar) reared in a real farm. Thus, the current study aimed to evaluate the effect of feeding BSFL meal to salmon in terms of fillet quality and sensory analysis at farm level conditions. Fish were fed a total of three diets (pellet size; 4.5 mm and 9 mm); a control diet (Control: 0% BSFL meal) formulated using a standard commercial recipe, containing FM (10%) and plant-based proteins. Two experimental diets were formulated using partially defatted BSFL meal (53% crude protein), in which plant-based proteins at 37% inclusion level from the control diet (4.5 mm pellets) were replaced by BSFL meal at 5% (BSFL 5%) and 10% (BSFL 10%). While for the 9.0 mm pellets, plant-based proteins at 35% were replaced by the BSFL meal at 5% and 10% inclusion level. All the three diets were formulated to be iso-nitrogenous and iso-lipidic diets. Diets were assigned to the sea-cages in triplicate (12 ×12 m; 1900 m3); housing ∼6000 fish per cage from 173 ± 2.7 g to harvest size 3.45 ± 74 kg for a period of 13 months. Feeding salmon with BSFL meal had no negative impact on the general fillet physical, chemical, and nutritional parameters. The fillet sensory evaluation showed that the control samples were associated with the typical attributes such as fresh salmon taste, while BSLF 10% to rancid taste but these attributes were not significantly different among the dietary groups. Overall, the current study showed that diet containing BSFL meal did not affect the general fillet parameters compared to salmon fed a commercial diet and thus validate the inclusion of BSFL meal up to 10% reared for a whole production cycle in sea cages.
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- 2024
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8. Role of individual and combined impact of simvastatin and α-TCP in rat calvarial bone defect: An experimental study
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Surendar Sugumaran, Deepak Selvam, M.S. Nivedhitha, Karthik Ganesh Mohanraj, Bader O. Almutairi, Selvaraj Arokiyaraj, Ajay Guru, and Jesu Arockiaraj
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Bone regeneration ,Xenograft ,Simvastatin ,α-tricalcium phosphate ,Calvarial defect ,Medicine ,Dentistry ,RK1-715 - Abstract
Background: Bone substitutes have been used by doctors for a long time to treat osseous abnormalities. Recently, scientists have been searching for suitable materials to replace bone. Autogenous bone grafts are considered the gold standard for osseous regeneration. However, the limited availability of intraoral sources for grafting material often requires the use of secondary donor sites. Aim: This study aims to compare a control group of standard critical bone defect models treated without any bone transplants to critical size calvarial bony defects treated with various bone replacements, including simvastatin and α-tricalcium phosphate, while analyzing the healing patterns. Materials and Methods: In this investigation, 24 Wistar Albino rats weighing 200–250 g were utilized. The study included four groups, each consisting of six rats. Group I utilized deproteinized bovine xenograft, Group II used Simvastatin (0.1 mg), Group III used Simvastatin (0.1 mg) plus TCP, and Group IV served as the untreated calvarial defects group. After eight weeks of testing, the rats were euthanized, and the calvaria were extracted, decalcified in 20% formic acid, and prepared for histological analysis. Results: The newly produced osseous tissue consisted of woven and lamellar bone, which was observed in all deformities. The mean widths of new bone development in the SIMV with α-TCP (Group III) group after XENO (Group I) and the control group with no graft implantation were 160.33 ± 16.2 µm, 110.59 ± 11.5 µm, and 50.83 ± 5.5 µm, respectively. However, these differences did not show statistical significance (p > 0.05). Conclusions: The quantity and quality of newly produced osseous tissue were comparable in α-TCP with SIMV and XENO. However, inflammatory infiltration was 8more pronounced in regions where SIMV was present alone compared to the combination group.
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- 2023
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9. TrackChain: Hyperledger based pharmaceutical supply chain – Resource utilization perspective
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C.M Naga Sudha and Jesu Vedha Nayahi J
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Pharmaceutical drugs ,Supply chain ,Hyperledger sawtooth ,Hyperledger fabric ,Resource consumption ,Science (General) ,Q1-390 ,Social sciences (General) ,H1-99 - Abstract
A distributed and decentralised ledger system shared by a variety of users in a peer-to-peer network is defined as a blockchain. Through its decentralised approach, it makes pharmaceutical products more accessible and secure for vendors, while they can maintain and access their inventories themselves. Between a company and its suppliers, a supply chain is used to produce and distribute a specific product or service, whose efficiency is increased with its integration in the supply chain. For efficient and transparent tracking of products, blockchain will be the right choice. In view of blockchain being incorporated into the supply chain system, it solves many logistical issues that supply chains face, such as appropriate data access, ensuring data quality, and many more. This can increase the traceability of the material supply chain and improve the maintenance of the list when there are several products to be supplied. Therefore, the concept of supply chain was developed in two platforms namely, Hyperledger Fabric and Hyperledger Sawtooth. Finally, Hyperledger Sawtooth was found to be well suited for creating decentralised apps or platforms with respect to resource utilization It enables developers to separate their application domain from the core system so that business rules for apps can exist without requiring knowledge of the primary platform's underlying architecture. The proposed system shows that Hyperledger Sawtooth framework consumes lower CPU than Fabric which helps in increasing the number of transactions.
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- 2024
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10. Expanding germ-organ theory: Understanding non-communicable diseases through enterobacterial translocation
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Seenivasan Boopathi, P. Snega Priya, B. Haridevamuthu, S.P. Ramya Ranjan Nayak, Munisamy Chandrasekar, Jesu Arockiaraj, and Ai-Qun Jia
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Germ-organ theory ,Gut microbiota ,Dysbiosis ,Uraemic toxins ,Metabolism ,Non-communicable diseases ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Diverse microbial communities colonize different habitats of the human body, including gut, oral cavity, nasal cavity and tissues. These microbial communities are known as human microbiome, plays a vital role in maintaining the health. However, changes in the composition and functions of human microbiome can result in chronic low-grade inflammation, which can damage the epithelial cells and allows pathogens and their toxic metabolites to translocate into other organs such as the liver, heart, and kidneys, causing metabolic inflammation. This dysbiosis of human microbiome has been directly linked to the onset of several non-communicable diseases. Recent metabolomics studies have revealed that pathogens produce several uraemic toxins. These metabolites can serve as inter-kingdom signals, entering the circulatory system and altering host metabolism, thereby aggravating a variety of diseases. Interestingly, Enterobacteriaceae, a critical member of Proteobacteria, has been commonly associated with several non-communicable diseases, and the abundance of this family has been positively correlated with uraemic toxin production. Hence, this review provides a comprehensive overview of Enterobacterial translocation and their metabolites role in non-communicable diseases. This understanding may lead to the identification of novel biomarkers for each metabolic disease as well as the development of novel therapeutic drugs.
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- 2023
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11. Gut Enterobacteriaceae and uraemic toxins - Perpetrators for ageing
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Seenivasan Boopathi, R.M. Saravana Kumar, P. Snega Priya, B. Haridevamuthu, S.P. Ramya Ranjan Nayak, Laura Chulenbayeva, Kushugulova Almagul, and Jesu Arockiaraj
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Gut dysbiosis ,Enterobacteriaceae ,Inflammaging ,Metabolic diseases ,Uraemic toxins ,Medicine ,Biology (General) ,QH301-705.5 - Abstract
Ageing is a complex process that is associated with changes in the composition and functions of gut microbiota. Reduction of gut commensals is the hallmarks of ageing, which favours the expansion of pathogens even in healthy centenarians. Interestingly, gut Enterobacteriaceae have been found to be increased with age and also consistently observed in the patients with metabolic diseases. Thus, they are associated with all-cause mortality, regardless of genetic origin, lifestyle, and fatality rate. Moreover, Enterobacteriaceae are also implicated in accelerating the ageing process through telomere attrition, cellular senescence, inflammasome activation and impairing the functions of mitochondria. However, acceleration of ageing is likely to be determined by intrinsic interactions between Enterobacteriaceae and other associated gut bacteria. Several studies suggested that Enterobacteriaceae possess genes for the synthesis of uraemic toxins. In addition to intestine, Enterobacteriaceae and their toxic metabolites have also been found in other organs, such as adipose tissue and liver and that are implicated in multiorgan dysfunction and age-related diseases. Therefore, targeting Enterobacteriaceae is a nuance approach for reducing inflammaging and enhancing the longevity of older people. This review is intended to highlight the current knowledge of Enterobacteriaceae-mediated acceleration of ageing process.
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- 2023
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12. A synthetic antioxidant molecule, GP13 derived from cysteine desulfurase of spirulina, Arthrospira platensis exhibited anti-diabetic activity on L6 rat skeletal muscle cells through GLUT-4 pathway
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Purabi Sarkar, Stefi V. Raju, Manikandan Velayutham, Ajay Guru, Mukesh Pasupuleti, Ebtesam M. Al Olayan, Amy F. Boushra, Annie Juliet, and Jesu Arockiaraj
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Diabetics ,Oxidative stress ,Antioxidant system ,L6 myotubes cells ,Insulin signaling ,Arthrrospira platensis ,Science (General) ,Q1-390 - Abstract
Objectives: Diabetes creates oxidative stress, which damages several organs and causes various problems including hyperglycemia, hyperlipidemia, hypertension, and maybe iron dyshomeostasis. Consequently, antioxidant therapy may be a promising strategy to avoid diabetes and diabetic complications. In the current study, we investigated the activity of the antioxidant GP13 peptide in an in-vitro diabetic model. Methods: All anti-diabetic and antioxidant in-vitro tests were performed on differentiated L6 myotubes cells. MTT assay was used to analyze the cytotoxic effect of the GP13 at different concentrations (10 μM to 80 μM) in the L6 cells. The DCFDA fluorescence was performed to confirm the radical scavenging effect of GP13 in the myotubule cells. The cells were treated with different concentrations of GP13 peptide before the enzyme assay was conducted. The differentiated L6 myotubes were kept for serum deprivation for 8 h before being treated with GP13 peptide. The RNA extraction from the L6 myotubes was performed using the Trizol reagent. Results: Cell viability analysis exhibited the non-toxic nature of GP13 in a dose-dependent manner (10 μM to 80 μM). Antioxidant enzyme, superoxide dismutase activity was 23.25 U/mL in the untreated group, whereas it was only 11.75 U/mL in the group that was exposed to GP13 at 80 μM. The catalase activity at 40 μM was slightly altered in the cells, while the hydrogen peroxide inhibition activity was higher (91.2%) compared to the control group. Additionally, GP13 showed anti-diabetic effects through a dose-dependent increase in glycogen storage (6.1 mM). It was discovered that 40 μM was the ideal concentration for the highest level of activity. Additionally, the genes involved in diabetes-related to antioxidants and the insulin signalling system were investigated. Conclusion: It is concluded that the GP13 peptide from A. platensis is a promising agent for anti-diabetic and antioxidant activities. To treat diabetes and its consequences, we thus propose that GP13 be regarded as a natural lead. The animal model design of this study has limitations, and further research is needed to draw conclusions about its therapeutic relevance to people.
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- 2023
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13. Evolutionary and in silico guided development of novel peptide analogues for antibacterial activity against ESKAPE pathogens
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Manjul Lata, Vrushti Telang, Pooja Gupta, Garima Pant, Mitra Kalyan, Jesu Arockiaraj, and Mukesh Pasupuleti
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Peptide analoguess ,Antimicrobial peptides ,ESKAPE pathogens ,In silico designing ,Hydrophobicity and charge relationships ,Burn wound model ,Microbiology ,QR1-502 ,Genetics ,QH426-470 - Abstract
According to WHO, to combat the resistant strains, new effective anti-microbial agents are needed on an urgent basis and global researchers should focus their efforts and discovery programs on developing them against antibiotic-resistant pathogens or priority pathogens like ESKAPE. In this context, Cationic antimicrobial peptides (AMPs) are being explored extensively as promising next-generation antimicrobials due to their broad range, fast kinetics and multifunctional role. Despite recent advances, it is still a daunting challenge to identify and design a potent AMP with no cytotoxicity, but with broad specific antimicrobial activity, stability and efficacy under in vivo conditions in a cost-effective and robust manner. In this work, as a proof of concept, we designed novel potent AMPs using artificial intelligence based in silico programs. Shortlisted peptide sequences were synthesized using the fmoc chemistry approach, assessed their antimicrobial activity, cell selectivity, mode of action and in vivo efficacy using a series of experiments. The synthesized peptide analogues demonstrated their antimicrobial activity (MIC in the range of 2.5–80 μM) against bacteria. The identified potential lead molecules showed antibacterial activity in physiological conditions with no signs of cytotoxicity. We further tested the antimicrobial activity of peptide analogues for treating wounds infected with Pseudomonas aeruginosa in the mice burn wound model. In drug-development programs, the identification of lead antimicrobial agents is always challenging and involves screening a large number of molecules which is time-consuming and expensive. This work demonstrates the utility of artificial intelligence based in silico analysis programs in discovering novel antimicrobial agents in an economical, robust way.
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- 2023
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14. Impact and fungitoxic spectrum of Trachyspermum ammi against Candida albicans, an opportunistic pathogenic fungus commonly found in human gut that causes Candidiasis infection
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Abirami Arasu, Vaahini Pingley, Nagaram Prabha, Ravikumar O.V., Kalidoss Annathurai, Sudharsan Kasirajan, Akshaya Govindasamy, Mona S. Alwahibi, Mohamed S. Elshikh, Mohamed R. Abdel Gawwad, and Jesu Arockiaraj
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Trachyspermum ammi ,Candida albicans ,Candidiasis ,GC–MS ,Flowcytometry ,Cell reduction assay ,Infectious and parasitic diseases ,RC109-216 ,Public aspects of medicine ,RA1-1270 - Abstract
Background: Trachyspermum ammi (commonly known as Ajwain), a medicinal plant of the Apiaceae family is scientifically acknowledged to harbor potential bioactive compounds for the treatment of gastrointestinal issues, loss of appetite, bronchial difficulties, cough, inflammation, diarrhoea, headache, hypertension, stomach discomfort, bronchitis and influenza. Candida albicans is generally a commensal fungus found in the gastrointestinal and genitourinary systems. Objective: This study was focused on secondary metabolites of T. ammi and its effects towards candidiasis infection as caused by C. albicans. Methods: Phytochemical components of T. ammi as a crude extract were extracted through maceration method using three polar (ethanol, methanol and water) and two non-polar (chloroform and diethyl ether) solvents and subjected to 14 phytochemical tests. Further, the crude extract of T. ammi was analyzed over gas chromatography–mass spectroscopy (GC–MS) and Fourier transform infrared spectroscopy (FTIR). Evaluation of antimicrobial property of the extract was carried out by minimum fungal concentration (MFC) and minimal inhibitory concentration (MIC). In addition, cell reduction assay was performed using flowcytometry to confirm the antifungal effect of Ajwain crude extract. Results: The aqueous extract showed high presence of phytochemicals including alkaloids, carbohydrates, flavonoids, resins, steroids, tannins, inorganic acids, organic acids, phenolic compounds, amino acids, protein and coumarins. GCMS analysis revealed seven bioactive compounds, in which thymol was detected in significant amount in the chromatogram. FTIR performance showed the presence of various stretching vibration including OH, CH, CC, CO, CN and COC. However, the MFC and MIC of Ajwain extracts using different solvent showed that the methanolic extract possesses maximum antifungal efficacy at 250 μg/ml and 15.6 μg/ml, respectively. In addition, cell reduction assay exhibited significant cell reduction in Ajwain methanolic extract compared to the other crude extracts used in the study. Conclusion: Overall, the findings revealed that Ajwain methanolic crude extract has antifungal activity against C. albicans; however, that further needs to be established at molecular level.
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- 2021
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15. S-adenosylmethionine synthase-derived GR15 peptide suppresses proliferation of breast cancer cells by upregulating the caspase-mediated apoptotic pathway: In vitro and in silico analyses
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Manikandan Velayutham, B. Haridevamuthu, Mohamed Farouk Elsadek, Humaira Rizwana, Annie Juliet, Kanchana M. Karuppiah, and Jesu Arockiaraj
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S-adenosylmethionine synthase ,Spirulina ,Oxidative stress ,Antioxidant ,Toxicity ,Science (General) ,Q1-390 - Abstract
Introduction: GR15 peptide is a potential antioxidant peptide which reduces intercellular ROS levels in zebrafish larvae stressed with H2O2. Cancer is a condition which develops during oxidative stress due to various reasons. Antioxidant molecules promote apoptosis or inhibit cancer cell proliferation by regulating the ROS level in cancer cells. This study identifies the anti-cancer potency of GR15 peptide derived from S-adenosylmethionine synthase of spirulina, Arthrospira platensis. We examined the anti-cancer property of this antioxidant peptide against breast cancer cells, MCF-7. Methods: An in-vitro anticancer activity of GR15 peptide was investigated by performing the following assays: MTT, Trypan blue assay, LDH assay and IC50 value calculation. Moreover, we examined the morphology of cancer cells under inverted microscope due to apoptosis staining AO/PI. The inter-cellular cancer level was measured by DCFDA staining, and the mitochondrial membrane potential was determined by Rhodamine 123. Further, the FACS analysis was performed to identify the changes in the cell cycle phases. Altered mRNA expressions of anti-cancer genes including Bcl-2, BAX, Caspase 3 and Caspase 9 were also addressed. Results: The GR15 peptide exhibit dose-dependent activity on MCF-7 cells. The MTT assay revealed that the GR15 peptide treatment at 45 µM showed 57 % inhibition of cancer cell proliferation. Also, the peptide significantly affects the cellular morphology and promotes apoptosis. GR15 treatment reduces the ROS level in a dose-dependent manner. The peptide is also exhibited mitochondrial membrane potential activity. As GR15 significantly upregulated the anti-cancer gene expression, an in-silico analysis was carried out to validate the anti-cancer activity. The molecular docking of GR15 showed good binding scores and significant amino acid interaction with the respective receptors. Conclusion: This study suggested that GR15 potentiates anticancer activity. It reduces ROS and subsequently regulates caspase-mediated apoptosis. Overall, the observations suggested that GR15 could be an anti-cancer peptide; however, further studies on in-vivo mammalian model or clinical trials need to be performed to prove the claims.
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- 2022
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16. Potential mechanism of Jatropha gossypifolia phenolic derivatives in enhancing insulin-signalling cascades GLUT 4, IRβ and GSK-3β in streptozotocin nicotinamide induced type II diabetic in wistar rat model
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Issac Praveen Kumar, P. Snega Priya, Ramu Meenatchi, Atif Abdulwahab A. Oyouni, Osama M. Al-Amer, Saad Ali S. Aljohani, Rami Adel Pashameah, Abdullah Hamadi, Mansuor A. Alanazi, and Jesu Arockiaraj
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Jatropha gossypifolia ,Wistar albino rats ,Streptozotocin–nicotinamide induction ,Gene and protein expression ,Anti-hyperglycemic activity ,Science (General) ,Q1-390 - Abstract
Objective: Diabetes mellitus is a metabolic syndrome that alters the composition of carbohydrates, proteins and fat content in the body due to decreased insulin secretion. This disrupts the insulin-signaling cascade, resulting in failure in the targeted tissues, such as insulin-stimulated glucose absorption muscle and fat. Natural products such as plants, which are rich in nutrient, offer a wide range of treatments for a number of diseases and infections including diabetes mellitus. Hence, this study investigates the anti-hyperglycemic efficacy of the methanolic leaves extract of Jatropha gossypifolia in experimental diabetic rats. Methods: Phytochemical constitution of J. gossypifolia showed tannin content to be significantly increased in methanolic extract and HPLC analysis also revealed phenolic derivative tannic acid to be main constitution. An intraperitoneal administration of 110 mg/kg body weight (b.w) nicotinamide and 45 mg/kg b.w. streptozotocin was provided to male Wistar albino rats, thus inducing diabetic. Diabetic induced rats treated with methanolic leaves extract of J. gossypifolia at the concentration between 100 and 50 mg/kg for 35 days. Periodic blood glucose level and body weight were measured. Methanolic extract influence was evaluated with q-PCR and western blot analysis on the cellular targets of insulin signaling cascades. Results: The results showed the decrease in blood glucose levels and increased serum insulin level in treated groups was significant (P
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- 2022
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17. Patent foramen ovale closure in India; Feasibility, challenges and mid-term outcomes
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Viji S. Thomson, Sanjith Aaron, Nathaniel Samson D, Jesu Krupa, A.T. Prabhakar, John Jose, Paul George, Oommen K. George, George Joseph, and Bijesh Kumar Yadav
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Patent foramen ovale (PFO) ,Cryptogenic stroke ,Embolic stroke of undetermined source(ESUS) ,Surgery ,RD1-811 ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Patent foramen ovale closure (PFO) is an underutilized therapy, and our study explored the challenges and feasibility of PFO closure in the Indian setting.Eighty patients with Embolic Stroke of Undetermined Source (ESUS) were screened by transcranial Doppler (TCD) for PFO. Twenty-nine patients underwent successful closure.High-risk features of a long tunnel, inter-atrial septal aneurysm, and large defect were present in 31%, 28%, and 59%. Transcranial Doppler had a sensitivity and specificity of 78% and 53% (p = 0.02) to detect PFO. Anticoagulation was withdrawn in 85% of patients post closure. Two patients had residual shunts at follow-up of 19 (9,34) months.
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- 2021
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18. Combined effects of various strategies to curtail exhaust emissions in a biomass waste fueled CI engine coupled with SCR system
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V. Praveena, M. Leenus Jesu Martin, and V. Edwin Geo
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Grapeseed biodiesel ,Nano emulsions ,Combustion ,Emissions ,EGR ,SCR ,Engineering (General). Civil engineering (General) ,TA1-2040 - Abstract
This study is an exhaustive investigation on engine performance and combustion features of a conventional diesel engine charged with biodiesel produced from biomass waste. Grapeseed oil methyl ester resulted in poor thermal efficiency with enormous quantity of harmful emissions. As an effort to reduce the engine pollutants, Grapeseed oil methyl ester was doped with zinc oxide nano particles, engine cylinder shape modification and exhaust gas recirculation method was used. Hydrocarbons, carbon monoxide and smoke emissions reduced considerably, whereas reduction in nitrogen oxide emissions was low. Selective catalytic reduction technique at optimized mass flow rate of aqueous urea solution minimized the nitrogen oxide emissions by 76.9% compared to grapeseed oil methyl ester without compromise in brake thermal efficiency.
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- 2022
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19. Antibiofilm efficacy of novel biogenic silver nanoparticles from Terminalia catappa against food-borne Listeria monocytogenes ATCC 15,313 and mechanisms investigation in-vivo and in-vitro
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Lakshmanan Muthulakshmi, Kannan Suganya, Maruthamuthu Murugan, Jamespandi Annaraj, Veeramuthu Duraipandiyan, Dunia A. Al Farraj, Mohamed S. Elshikh, Annie Juliet, Mukesh Pasupuleti, and Jesu Arockiaraj
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Terminalia catappa ,Listeria monocytogenes ,Caenorhabditis elegans ,Silver nanoparticles ,Antibiofilm ,Science (General) ,Q1-390 - Abstract
Listeria monocytogenes (LM) is a potential foodborne pathogen, known to form biofilms, which ultimately leads to serious problems in the food industry. This study demonstrates a comprehensive approach for the synthesis of silver nanoparticles using the phytochemicals present in the leaf aqueous extract of Terminalia catappa for the inhibition of L. monocytogens biofilms. The phytochemical analysis by UV–vis spectrum of the extract revealed the presence of polyphenolic compounds such as ellagic acid, gallic acid, chebulinic acid, and chebulgic acid. The shape, structure and size of the synthesized AgNPs were determined as 23–100 nm using the scanning electron microscopic images, and particle size distribution curve analysis. The in vitro studies using the AgNPs against L. monocytogenes revealed the inhibition of biofilm formation, reduction in the Virulence factors such as protease production at sub-inhibitory concentrations of AgNPs. In vivo experiments performed with the Caenorhabditis elegans model showed that AgNPs prolonged the lifespan of infected worms by about 90%. In addition, the non-hazardous nature and in vivo anti-adherence potential of AgNPs were also established with LM - C. elegans infection model.
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- 2022
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20. Ventricular noncompaction and long QT syndrome – A deadly double hit for the foetus
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Anne George Cherian, Pramitha Lankala, Jesu Krupa, and John Roshan
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Electrophysiology ,Fetal arrhythmias ,Low resource setting ,Long QT syndrome ,Ventricular non compaction ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Congenital long QT syndrome [LQTS] is a channelopathy characterized by QT prolongation and polymorphic VT. LQTS however need not be a purely electrical disease. Defects in ion channels may cause myocardial architectural disruption leading to ventricular non compaction [VNC]. It is defined as the presence of prominent ventricular trabeculations and deep intertrabecular recesses within the endomyocardium. We describe the in-utero management of a foetus who was later found to have LQTS with VNC. The detection of ventricular tachycardia and complete heart block in utero should arouse the suspicion of LQTS. It would be wise to avoid QT prolonging antiarrhythmics in this subset of patients.
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- 2021
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21. Neuroprotective and antioxidant capability of RW20 peptide from histone acetyltransferases caused by oxidative stress-induced neurotoxicity in in vivo zebrafish larval model
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Nagaram Prabha, Ajay Guru, Ramasamy Harikrishnan, Mansour K. Gatasheh, Ashraf Atef Hatamleh, Annie Juliet, and Jesu Arockiaraj
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Antioxidant peptide ,Histone acetyltransferases ,Oxidative stress ,Neuroprotection ,Neurotoxicity ,Science (General) ,Q1-390 - Abstract
Oxidative stress causes disruption of cell macromolecules and resulting neurodegeneration when the antioxidant defense mechanism is inhibited. Oxidative stress is emerging as a key therapeutic target for nerve agent toxicity. Therefore, antioxidant treatment methods are a novel and effective approach to attenuate oxidative stress and neurodegeneration. This study evaluated the neuroprotective and antioxidant ability of a short peptide, RW20 derived from histone acetyltransferases (HATs).Using bioinformatics tools, the short amino acid sequence of RF13 peptide with antioxidant activity was predicted from HAT of Channa striatus transcriptome. The synthesized antioxidant peptide at various concentrations (10–50 μM) was analyzed in in vitro and in vivo antioxidant assay. The neuroprotective effect of RF13 peptide was evaluated in H2O2 stressed zebrafish larvae.The results showed the neuroprotective effect by restoring antioxidant enzymes including SOD, CAT, GPx, GSH, and GST treated with RW20. In addition, the oxidative stress indicator of lipid peroxidation was gradually declined with an increase in the concentration of peptides. It was also shown to attenuate neuronal damage by inhibiting nitric oxide overproduction, thus increasing AChE activity. Further, to validate the neuroprotective effect of RW20, the intracellular ROS level and apoptosis in the zebrafish larvae were analyzed by incubating the larvae along with RW20, which decreased intracellular ROS level and reduced the cell death.Overall, the study demonstrated that RW20 possessed prominent antioxidant activity. Hence, we conclude that RW20 can be developed as a potent therapeutic agent against oxidative stress-induced neurodegenerative diseases.
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- 2022
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22. GP13, an Arthrospira platensis cysteine desulfurase-derived peptide, suppresses oxidative stress and reduces apoptosis in human leucocytes and zebrafish (Danio rerio) embryo via attenuated caspase-3 expression
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Purabi Sarkar, Ajay Guru, Stefi V. Raju, Abdullah Farasani, Atif Abdulwahab A. Oyouni, Othman R. Alzahrani, Hussam Awwadh E. Althagafi, Fahad Alharthi, Kanchana M. Karuppiah, and Jesu Arockiaraj
- Subjects
Antioxidant activity ,Cysteine desulfurase ,Arthrospira platensis ,Oxidative damage ,Caspase-3 ,Zebrafish ,Science (General) ,Q1-390 - Abstract
Arthrospira platensis (Ap) has several advantageous adaptive mechanisms including its efficient response to elevated oxidative stress (OS). This study intends to identify the antioxidant effect, in vitro and in vivo, of a novel peptide (GP13), Ap-derived cysteine-desulfurase (CDS) peptide, for antioxidant role and the associated mechanism(s) by which the GP13 elicits cytoprotection under elevated OS.Using bioinformatics tools, a short sequence of amino acids GP13 with a predicted antioxidant effect has been identified from the cysteine sulfurase domain of ApCDS between 243 and 616 amino acids. The synthesized GP13 peptide expressed significant antioxidant activity against free-radicals at various concentrations (10–80 µM), as established through the DPPH, ABTS, SARS, and HRS assays.Besides, GP13 demonstrated no cytotoxicity on Vero cells and human leucocytes. In H2O2-induced human leucocytes, the peptide exhibited maximum ROS scavenging activity at a concentration of 80 µM. Reduced apoptotic body formation was identified using Hoechst 33,342 staining in GP13-exposed Vero cells. In vivo results revealed that pre-treated zebrafish larvae with GP13 (10–80 µM) ameliorated the H2O2-induced oxidative damage. Further, GP13 inhibited the H2O2-induced caspase-3-dependent apoptotic response at 96 h post fertilized (hpf) zebrafish larvae.Together, results demonstrated that in GP13 treated (80 µM) zebrafish there was a reduction in the expression of lipid peroxidation level; and an increase in antioxidant-enzymes. Therefore, it is possible that GP13 peptide derived from ApCDS has in vitro and in vivo antioxidant activity and that GP13 should be further investigated for potential therapeutic utility in OS-mediated complications.
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- 2021
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23. Standards and Protocols of Blockchain
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Naga Sudha, C.M., primary, Gokulakrishnan, K., additional, and Jesu Vedha Nayahi, J., additional
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- 2021
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24. Contributors
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Amuthan, A., primary, Ananth Kumar, T., additional, Ashok, V., additional, Bibal Benifa, J.V., additional, Chelladurai, Usharani, additional, Dinesh Kumar, R., additional, Ganesan, Lakshmi Prabha, additional, Goje, Amol, additional, Gokulakrishnan, K., additional, Golden Julie, E., additional, Harold Robinson, Y., additional, Idas, S. Jeba Prasanna, additional, Jaya Kumar, A., additional, Jesu Vedha Nayahi, J., additional, Jeyabharathi, D., additional, Kesavaraja, D., additional, Krishnan, Saravanan, additional, Kumaresh, Sakthi, additional, Manaswini, V.N.S., additional, Mani, A.S. Radha, additional, Markavathi, J. Nulyn Punitha, additional, Naga Sudha, C.M., additional, Nishanth, R., additional, Padmapriya, V., additional, Pandey, Sneha, additional, Pandian, Seethalakshmi, additional, Porkodi, S., additional, Rajalakshmi, N.R., additional, Sangeetha, T., additional, Satyanarayana Tallapragada, V.V., additional, Setiya, Rishabh, additional, Shamkuwar, Madhavi, additional, Sharma, Deepak Kumar, additional, Sharma, Neha, additional, Singh, Ayush Kumar, additional, Singh, Inderjit, additional, Sujatha, D.N., additional, Sundaresan, S., additional, Suresh Kumar, K., additional, Thava, Angelin Merling, additional, Usha, V., additional, and Venifa Mini, G., additional
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- 2021
- Full Text
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25. Intracellular free radical scavenging activity and protective role of mammalian cells by antioxidant peptide from thioredoxin disulfide reductase of Arthrospira platensis
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Anbazahan Sannasimuthu and Jesu Arockiaraj
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Thioredoxin disulfide reductase ,Arthrospira platensis ,Antioxidant peptide ,Hydrogen peroxide ,Gene expression ,Nutrition. Foods and food supply ,TX341-641 - Abstract
In this study, we have analyzed the antioxidant role of thioredoxin disulfide reductase (TR) identified from Arthrospira platensis (Ap). A short peptide (VH12) derived from thioredoxin domain between Val368 and His379 of ApTR and it named as VH12. The peptide expressed the antioxidant activity against hydroxyl radical and superoxide radical at the concentration of 6.25 µM. Cytotoxic activity was performed on human leucocytes which showed that VH12 is not cytotoxic to any of the cellular population of human leucocytes. In addition, we determined the intracellular ROS level in cardiac myocytes to know the ROS scavenging level of VH12 peptide; the level of ROS scavenging was nearly 55% by the peptide at a concentration of 12.5 µM. Finally, the ROS scavenging of the VH12 peptide was tested against H2O2 stress induced zebrafish embryo, in which the intracellular ROS was reduced by the peptide at a concentration of 20 µM.
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- 2019
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- View/download PDF
26. Sustainable bio composites for aircraft components
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Arockiam, Naveen Jesu, primary, Jawaid, Mohammad, additional, and Saba, Naheed, additional
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- 2018
- Full Text
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27. List of Contributors
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Amiri, Ali, primary, Arockiam, Naveen Jesu, additional, Asim, Mohammad, additional, Balasubramanian, K., additional, Basavegowda, Yogesha, additional, Boccardi, Simone, additional, Burkart, Victoria, additional, Carlomagno, Giovanni M., additional, Chandrasekar, Muthukumar, additional, Ghori, Syed Waheedullah, additional, Gobalakrishnan, Mohana K., additional, Ishak, M.R., additional, Jamir, Mohammad R.M., additional, Jawaid, Mohammad, additional, Jayakrishna, Kandasamy, additional, Kar, Vishesh R., additional, Khasri, Azduwin, additional, Kreculj, Dragan, additional, Leman, Z., additional, Loganathan, Tamil M., additional, Majid, Mohammad S.A., additional, Meola, Carosena, additional, Muda, Mohd Khirul Hafiz, additional, Mustapha, Faizal, additional, Nasir, Mohammad, additional, Puttegowda, Madhu, additional, Rahim, Erween A., additional, Rajesh, Murugan, additional, Rajeswari, N., additional, Rajini, N., additional, Rangappa, Sanjay Mavinakere, additional, Rasheed, Masrat, additional, Rasuo, Bosko, additional, Saba, Naheed, additional, Sapuan, S.M., additional, Sasahara, Hiroyuki, additional, Senthilkumar, K., additional, Shivanna, Pradeep, additional, Siakeng, Ramengmawii, additional, Siengchin, Suchart, additional, Siva, I., additional, Sultan, Mohamed T.H., additional, Ulven, Chad, additional, Webster, Dean, additional, Winowlin Jappes, J.T., additional, and Yu, Arvin, additional
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- 2018
- Full Text
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28. Contributors
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A. Amuthan, T. Ananth Kumar, V. Ashok, J.V. Bibal Benifa, Usharani Chelladurai, R. Dinesh Kumar, Lakshmi Prabha Ganesan, Amol Goje, K. Gokulakrishnan, E. Golden Julie, Y. Harold Robinson, S. Jeba Prasanna Idas, A. Jaya Kumar, J. Jesu Vedha Nayahi, D. Jeyabharathi, D. Kesavaraja, Saravanan Krishnan, Sakthi Kumaresh, V.N.S. Manaswini, A.S. Radha Mani, J. Nulyn Punitha Markavathi, C.M. Naga Sudha, R. Nishanth, V. Padmapriya, Sneha Pandey, Seethalakshmi Pandian, S. Porkodi, N.R. Rajalakshmi, T. Sangeetha, V.V. Satyanarayana Tallapragada, Rishabh Setiya, Madhavi Shamkuwar, Deepak Kumar Sharma, Neha Sharma, Ayush Kumar Singh, Inderjit Singh, D.N. Sujatha, S. Sundaresan, K. Suresh Kumar, Angelin Merling Thava, V. Usha, and G. Venifa Mini
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- 2021
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29. Standards and Protocols of Blockchain
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C.M. Naga Sudha, J. Jesu Vedha Nayahi, and K. Gokulakrishnan
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Proof-of-stake ,Authentication ,Consensus ,Computer science ,Interface (Java) ,Proof-of-work system ,Distributed transaction ,Computer security ,computer.software_genre ,Byzantine fault tolerance ,computer ,Heterogeneous network - Abstract
In the present digital world, the day-to-day activities of human life is managed digitally, and often the scenario of “anything, anytime, and anywhere” holds. The three-dimensional buzz words which revolve globally are Internet of Things, Industry 4.0, and Smart Cities. Smart cities are feasible today because of the advancements in technologies such as ubiquitous sensing, heterogeneous network, intelligent sensing, and processing of information and control systems. Security is a major concern when all the daily chores are managed digitally. Therefore, more research has to be focused on security aspects to ensure authentication, privacy, and trust. Blockchain is providing a significant contribution to achieving a secured platform for distributed transaction management. There is a stringent need to discuss in detail the various standards and protocols of blockchain. This chapter explains the standards and categorization of blockchain and its protocols. It includes the protocols of network and data organization, distributed consensus protocols, the framework of autonomous organization that relies on smart contracts executed in distributed virtual machines, and the human–machine interface implementations. There are three main categories of consensus protocols namely, Proof of Work, Proof of Stake, and Byzantine Fault Tolerant which are categorized based on the applications.
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- 2021
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30. Advancement in fiber reinforced polymer, metal alloys and multi-layered armour systems for ballistic applications – a review
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Bhat, Aayush, Naveen, Jesu, Jawaid, Mohammad, M. N. F., Norrrahim, Rashedi, Ahmad, Khan, Anish, Bhat, Aayush, Naveen, Jesu, Jawaid, Mohammad, M. N. F., Norrrahim, Rashedi, Ahmad, and Khan, Anish
- Abstract
The recent research and development performed for armour systems for material selection and analysis has helped discover new and significant material properties suited for ballistic applications. The realm of ballistic studies has employed advanced materials to provide the desired performance, considering the strict requirement of perfect material selection for armour systems. Energy absorption, ballistic limit, and depth of indentation are the most important parameters to be analyzed for an efficient armour system. The importance of utilizing appropriate materials for armour system is necessary, to achieve higher energy absorption, ballistic limit, and low blunt trauma (<44 mm), while simultaneously ensuring the armour has low weight. The aim of this review is to analyze the different armour systems such as fiber reinforced polymeric composites, metallic and multilayer armour systems (MAS) to understand their response on ballistic impact. Also, the importance of advanced fabrication techniques such as bio-inspired fabrication and additive manufacturing for armour applications has been addressed in detail. Moreover, this review critically analyzed the possible ways to enhance the ballistic performance of fiber reinforced polymeric composites, metallic materials, and MAS.
- Published
- 2021
31. Pharmacological importance of TG12 from tachykinin and its toxicological behavior against multidrug-resistant bacteria Klebsiella pneumonia
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Raju, Stefi V., Sarkar, Purabi, Pasupuleti, Mukesh, Saraswathi, Nambiappan T., Arasu, Mariadhas Valan, Al-Dhabi, Naif Abdullah, Esmail, Galal Ali, Arshad, Aziz, Arockiaraj, Jesu, Raju, Stefi V., Sarkar, Purabi, Pasupuleti, Mukesh, Saraswathi, Nambiappan T., Arasu, Mariadhas Valan, Al-Dhabi, Naif Abdullah, Esmail, Galal Ali, Arshad, Aziz, and Arockiaraj, Jesu
- Abstract
Development of antimicrobial drugs against multidrug-resistant (MDR) bacteria is a great focus in recent years. TG12, a short peptide molecule used in this study was screened from tachykinin (Tac) protein of an established teleost Channa striatus (Cs) transcriptome. Tachykinin cDNA has 345 coding sequence, that denotes a protein contained 115 amino acids; in which a short peptide (TG12) was identified at 83–94. Tachykinin mRNA upregulated in C. striatus treated with Aeromonas hydrophila and Escherichia coli lipopolysaccharide (LPS). The mRNA up-regulation was studied using real-time PCR. The up-regulation tachykinin mRNA pattern confirmed the immune involvement of tachykinin in C. striatus during infection. Further, the identified peptide, TG12 was synthesized and its toxicity was demonstrated in hemolytic and cytotoxic assays using human erythrocytes and human dermal fibroblast cells, respectively. The toxicity study exhibited that the toxicity of TG12 was similar to negative control, phosphate buffer saline (PBS). Moreover, the antibiogram of TG12 was active against Klebsiella pneumonia ATCC 27736, a major MDR bacterial pathogen. Further, the antimicrobial activity of TG12 against pathogenic bacteria was screened using minimum inhibitory concentration (MIC) and anti-biofilm assays, altogether TG12 showed potential activity against K. pneumonia. Fluorescence assisted cell sorter flow cytometer analysis (FACS) and field emission scanning electron microscopy (FESEM) was carried on TG12 with K. pneumonia; the results showed that TG12 significantly reduced K. pneumonia viability as well as TG12 disrupt its membrane. In conclusion, TG12 of CsTac is potentially involved in the antibacterial immune mechanisms, which has a prospectus efficiency in pharma industry against MDR strains, especially K. pneumonia.
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- 2021
32. GR15 peptide of S-adenosylmethionine synthase SAMe from Arthrospira platensis demonstrated antioxidant mechanism against H2O2 induced oxidative stress in in-vitro MDCK cells and in-vivo zebrafish larvae model
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Velayutham, Manikandan, Guru, Ajay, Arasu, Mariadhas Valan, Al-Dhabi, Naif Abdullah, Choi, Ki Choon, Elumalai, Preetham, Harikrishnan, Ramasamy, Arshad, Aziz, Arockiaraj, Jesu, Velayutham, Manikandan, Guru, Ajay, Arasu, Mariadhas Valan, Al-Dhabi, Naif Abdullah, Choi, Ki Choon, Elumalai, Preetham, Harikrishnan, Ramasamy, Arshad, Aziz, and Arockiaraj, Jesu
- Abstract
GR15 is a short molecule or peptide composed of aliphatic amino acids and possesses to have antioxidant properties. The GR15, 1GGGAFSGKDPTKVDR15 was identified from the protein S-adenosylmethionine synthase (SAMe) expressed during the sulfur departed state of Arthrospira platensis (spirulina or cyanobacteria). The in-silico assessment and the structural features of GR15 showed its antioxidant potency. Real-time PCR analysis found the up-regulation of ApSAMe expression on day 15 against oxidative stress due to 10 mM H2O2 treatment in A. platensis (Ap). The antioxidant activity of GR15 was accessed by the cell-free antioxidant assays such as ABTS, SARS, HRAS and NO; the results showed dose-dependent antioxidant activity. The toxicity assay was performed in both in vitro and in vivo models, in which peptide does not exhibit any toxicity in MDCK cell and zebrafish embryos. The intercellular ROS reduction potential of GR15 peptide was also investigated in both in vitro and in vivo models including LDH assay, antioxidant enzymes (SOD and CAT), and fluorescent staining assay (DCFDA, Hochest and Acridine orange sting) was performed; the results showed that the GR15 peptide was effectively reduced the ROS level. Further, RT-PCR demonstrated that GR15 enhanced the antioxidant property and also up-regulated the antioxidant gene, thus reduced the ROS level in both in vitro and in vivo models. Based on the results obtained from this study, we propose that GR15 has the potential antioxidant ability; hence further research can be directed towards the therapeutic product or drug development against disease caused by oxidative stress.
- Published
- 2021
33. Dietary selenium required to achieve body homeostasis and attenuate pro-inflammatory responses in Atlantic salmon post-smolt exceeds the present EU legal limit
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Marta S. Silva, P. Antony Jesu Prabhu, Kristin Hamre, Erik-Jan Lock, Rune Waagbø, May-Helen Holme, Elisabeth Holen, and Marit Espe
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0303 health sciences ,Kidney ,medicine.diagnostic_test ,chemistry.chemical_element ,04 agricultural and veterinary sciences ,Aquatic Science ,Hematocrit ,Biology ,Feed conversion ratio ,03 medical and health sciences ,Basal (phylogenetics) ,medicine.anatomical_structure ,Fish meal ,Animal science ,chemistry ,In vivo ,040102 fisheries ,medicine ,0401 agriculture, forestry, and fisheries ,Homeostasis ,Selenium ,030304 developmental biology - Abstract
Selenium (Se) supplementation either as inorganic or organic form was evaluated in Atlantic salmon post-smolt in vivo and in vitro. The basal diet was formulated to be low in fish meal and contain 0.24 mg Se kg−1; six other diets with Se inclusion of 0.15, 0.4, 0.7 or 1.1 mg kg−1 as sodium selenite (SS) and 0.15 or 0.4 mg kg−1 as L-selenomethionine (SM) were formulated from the basal diet. The diets were fed to Atlantic salmon post-smolt (mean initial weight, 216 ± 27 g) in triplicate groups (35 fish tank−1) and reared in flow-through seawater (33 ppt) at 10–12 °C for 9 weeks. At the end of the feeding trial, whole fish and tissues were sampled for in vivo assessment; whereas, liver cells and head kidney leukocytes (HKL) were isolated and their primary cultures used for in vitro assessment following exposure to hydrogen peroxide (H2O2), lipopolysaccharide (LPS) or poly I:C (PIC). Growth, feed intake, feed conversion ratio, specific growth rate, hepato-somatic index, proximate composition and mineral concentration of the whole fish (except for Se) were unaffected by dietary Se (p > .05). Hematocrit was significantly higher in fish fed the 0.4 mg Se supplemented feeds, irrespective of the Se source (p = .02). The Se concentration in whole body, liver, muscle, plasma, kidney and liver/kidney Se ratio increased with increasing dietary Se concentration (p < .0001). Level of oxidised glutathione (GSSG) in liver and head kidney followed a quadratic function (p < .05) indicating that the concentrations were lower at intermediate SS supplementation of 0.4 and 0.65 mg Se kg−1 (total Se, 0.65 and 0.87 mg Se kg−1). Impact of Se sources on glutathione redox status was similar. Slope-ratio analysis revealed SM to be more efficient than SS in improving apparent availability, whole body or tissues Se status, Se retention and reducing Se loss to the environment. In vitro, the mRNA expression of p38mapk and aif, in liver cells were affected by the impact of dietary Se, but not by the treatment of H2O2 (p < .05). In the HKL, the LPS and PIC induced pro-inflamatory action of il-1β, cox2, nfkβ and viperin were attenuated by SM supplementation, but not by SS (p < .001). Dietary Se supplementation required to the basal diet containing 0.24 mg Se kg−1 was 0.41 mg Se as SS (total 0.65 mg kg−1) or 0.17 mg Se as SM (total 0.41 mg kg−1) based on body Se homeostasis or tissue Se status. SM inclusion at 0.4 mg kg−1 diet (total, 0.65 mg kg−1) attenuated LPS or PIC induced pro-inflammatory responses in vitro. Overall, Se requirement of Atlantic salmon post smolt was 0.27 mg kg−1 diet, on availale basis. Dietary Se level required to maintain body Se homeostasis and improved health status of Atlantic salmon fed plant-based diets (0.65 mg kg−1 diet) exceed the existing EU maximum limit of 0.5 mg Se kg−1 diet. SM as the Se source in salmon feeds has the potential to improve salmon health and reduce Se emissions from Norwegan salmon farming by 60 to 70%. publishedVersion
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- 2020
34. Innate immune function of serine/threonine-protein kinase from Macrobrachium rosenbergii in response to host-pathogen interactions
- Author
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Ravichandran, Gayathri, Pasupuleti, Mukesh, Arasu, Mariadhas Valan, Al-Dhabi, Naif Abdullah, Arshad, Aziz, Arockiaraj, Jesu, Ravichandran, Gayathri, Pasupuleti, Mukesh, Arasu, Mariadhas Valan, Al-Dhabi, Naif Abdullah, Arshad, Aziz, and Arockiaraj, Jesu
- Abstract
The occurrences of multiple drug-resistant strains have been relentlessly increasing in recent years. The aquaculture industry has encountered major disease outbreaks and crucially affected by this situation. The usage of non-specific chemicals and antibiotics expedites the stimulation of resistant strains. Triggering the natural defense mechanism would provide an effective and safest way of protecting the host system. Hence, we have investigated the innate immune function of serine/threonine-protein kinase (STPK) in Macrobrachium rosenbergii (Mr). The in-silico protein analysis resulted in the identification of cationic antimicrobial peptide, MrSL-19, with interesting properties from STPK of M. rosenbergii. Antimicrobial assay, FACS and SEM analysis demonstrated that the peptide potentially inhibits Staphylococcus aureus by interacting with its membrane. The toxic study on MrSL-19 demonstrated that the peptide is not toxic against HEK293 cells as well as human erythrocytes. This investigation showed the significant innate immune property of an efficient cationic antimicrobial peptide, MrSL-19 of STPK from M. rosenbergii.
- Published
- 2020
35. Apparent availability of zinc, selenium and manganese as inorganic metal salts or organic forms in plant-based diets for Atlantic salmon (Salmo salar)
- Author
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P. Antony Jesu Prabhu, Robin Ørnsrud, Wolfgang M. Koppe, Heidi Amlund, Marta S. Silva, Rune Waagbø, Pedro Araujo, and Saskia Kröckel
- Subjects
Atlantic salmon ,chemistry.chemical_element ,Manganese ,Zinc ,Aquatic Science ,Biology ,03 medical and health sciences ,chemistry.chemical_compound ,Full factorial design ,Chelation ,Food science ,Salmo ,Inductively coupled plasma mass spectrometry ,030304 developmental biology ,0303 health sciences ,Phytic acid ,Mineral requirement ,04 agricultural and veterinary sciences ,biology.organism_classification ,chemistry ,Digestibility ,040102 fisheries ,0401 agriculture, forestry, and fisheries ,Composition (visual arts) ,Selenium - Abstract
The composition of salmonid diets has changed from the use of mainly marine ingredients to increased use of plant ingredients, and this has an impact on the mineral content and availability. Minerals, like zinc (Zn), selenium (Se) and manganese (Mn), are supplemented to diets as inorganic or organic forms to cover the nutritional requirements of fish. This study compared the apparent availability (AA) of Zn, Se and Mn from inorganic metal salts and their organic forms in Atlantic salmon. Sixteen diets were prepared based on a two-level factorial design (24). The tested factors were Zn additive source (A), Se additive source (B), Mn additive source (C) and phytic acid level (D). The diets were fed to Atlantic salmon for 11 days, faeces were collected by stripping, and the total content of mineral and yttrium in diets and faeces were determined by inductively coupled plasma mass spectrometry. Data obtained were used to estimate the AA for the minerals. Zinc additive source had no significant effect on the AA of Zn. However, the Se and Mn additive source had significant effects on the AA of Se and Mn, respectively. Higher AA of Se was achieved with selenomethionine than with selenite, and Mn sulphate was more available than Mn chelate of glycine. The phytic acid level did not significantly affect the AA of Zn, Se or Mn. However, several interactions between mineral additive sources and the phytic acid level significantly affected the AA of Zn, Se and Mn. publishedVersion
- Published
- 2019
36. Mechanical and moisture diffusion behaviour of hybrid Kevlar/Cocos nucifera sheath reinforced epoxy composites
- Author
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Arockiam, Naveen Jesu, Jawaid, Mohammad, Zainudin, Edi Syams, Hameed Sultan, Mohamed Thariq, R., Yahaya, Arockiam, Naveen Jesu, Jawaid, Mohammad, Zainudin, Edi Syams, Hameed Sultan, Mohamed Thariq, and R., Yahaya
- Abstract
The aim of this research is partial replacement of plain woven Kevlar 29(K) with naturally woven cocous nucifera sheath (CS) waste. Laminated K/CS reinforced epoxy hybrid composites were fabricated by hand lay-up method followed by hot compression moulding with 105 °C temperature at 275 bar pressure for 1 h. The total fibre loading of the hybrid composite was maintained 45 wt.% and the ratio of Kevlar and Cocous nucifera sheath varies in weight fraction of 100/0, 75/25, 50/50, 25/75, and 0/100. Mechanical (tensile, flexural, impact), moisture diffusion and morphological behaviour of the laminated composites were evaluated. The results showed that the hybrid composites (75/25) declined the tensile strength by 19% compared to Kevlar fabric reinforced epoxy composites. But, the hybrid composites (75/25) exhibited highest flexural strength (175 MPa) and flexural modulus (18 GPa) than pure Kevlar reinforced epoxy composites. Moreover, the impact toughness of hybrid composites (86 kJ/m2) at 75/25 wt.% showed good agreement with the pure Kevlar fabric reinforced polymer composites (90 kJ/m2). From the moisture diffusion analysis, hybrid composites (75/25) exhibited better moisture resistance. Statistical analysis of the results has been carried out using one way-ANOVA (analysis of variance) and it shows that there is a statically significant difference between the obtained mechanical properties of the laminated composites. Morphology of the tensile fractured laminates showed the delamination's, matrix cracking and fibre/matrix adhesion. From the results, it has been concluded that naturally woven Cocos nucifera sheath has the potential to replace Kevlar fabric in the polymer composites exclusively for defence applications.
- Published
- 2019
37. Effects of layering sequence and gamma radiation on mechanical properties and morphology of Kevlar/oil palm EFB/epoxy hybrid composites
- Author
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Muhammad Amir, Siti Madiha, Hameed Sultan, Mohamed Thariq, Jawaid, Mohammad, Safri, Syafiqah Nur Azrie, Md Shah, Ain Umaira, Yusof, Mohd Ridzuan, Arockiam, Naveen Jesu, Mohd, Shukri, Salleh, Khairul A. M., Saba, Naheed, Muhammad Amir, Siti Madiha, Hameed Sultan, Mohamed Thariq, Jawaid, Mohammad, Safri, Syafiqah Nur Azrie, Md Shah, Ain Umaira, Yusof, Mohd Ridzuan, Arockiam, Naveen Jesu, Mohd, Shukri, Salleh, Khairul A. M., and Saba, Naheed
- Abstract
The present study evaluates the tensile and flexural properties, including the morphological features of gamma radiated Kevlar/oil palm empty fruit bunch (EFB)/epoxy hybrid composites fabricated using hand lay-up method with different layering sequences. The fabricated hybrid composites were exposed to different gamma radiation doses: 25 kGy, 50 kGy and 150 kGy. Mechanical (tensile and flexural) and morphological properties were evaluated by using universal testing machine and scanning electron microscopy, respectively. Results obtained indicated that tensile strength of hybrid composites were effected by layering sequence. The layering sequence involving the use of EFB as core material yielded better mechanical performance compared to the layering pattern when Kevlar served as the core material. The tensile and flexural properties of hybrid composites showed an improvement for irradiated samples at a low radiation level. Hybrid composites displayed decrease in tensile strength at 50 kGy whereas flexural strength still showed an improvement. However, at 150 kGy, the tensile and flexural properties exhibited significant degradation. FESEM of tensile fracture composites showed the exist of fibre pull out and voids. However, at 150 kV bigger and ruptured voids were observed. It can be concluded from this finding that mechanical performance of Kevlar/EFB/Kevlar hybrid composites after Gamma radiation, has made it as promising material for automotive, aerospace and construction applications.
- Published
- 2019
38. Sustainable bio composites for aircraft components
- Author
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Naheed Saba, Mohammad Jawaid, and Naveen Jesu Arockiam
- Subjects
Engineering ,Moisture absorption ,Product design ,Scope (project management) ,business.industry ,05 social sciences ,02 engineering and technology ,021001 nanoscience & nanotechnology ,Aircraft manufacturing ,050501 criminology ,Polymer composites ,Composite material ,0210 nano-technology ,business ,Aerospace ,Natural fiber ,0505 law ,Flammability - Abstract
Due to the environmental regulations and increase in awareness about eco-friendly materials, most of the aerospace structure researchers have focussed on green composites which are reusable and recyclable, whereas the current synthetic fiber-based thermoset composites cannot be recyclable. Leading aircraft manufacturing firms such as Airbus and Boeing have started their research into the use of natural fiber as a potential material for aircraft interiors. Extensive research in the natural fiber-based green composites with respect to the aircraft structure is required, especially moisture absorption, flammability, surface modification techniques, and the impact of advanced nanomaterials on green composites. This chapter addresses the advantages and drawbacks of natural fiber in the aircraft structures, aircraft product design stages, and aerospace components which have been made using natural fiber-reinforced polymer composites, and includes case studies and future scope.
- Published
- 2018
- Full Text
- View/download PDF
39. List of Contributors
- Author
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Ali Amiri, Naveen Jesu Arockiam, Mohammad Asim, K. Balasubramanian, Yogesha Basavegowda, Simone Boccardi, Victoria Burkart, Giovanni M. Carlomagno, Muthukumar Chandrasekar, Syed Waheedullah Ghori, Mohana K. Gobalakrishnan, M.R. Ishak, Mohammad R.M. Jamir, Mohammad Jawaid, Kandasamy Jayakrishna, Vishesh R. Kar, Azduwin Khasri, Dragan Kreculj, Z. Leman, Tamil M. Loganathan, Mohammad S.A. Majid, Carosena Meola, Mohd Khirul Hafiz Muda, Faizal Mustapha, Mohammad Nasir, Madhu Puttegowda, Erween A. Rahim, Murugan Rajesh, N. Rajeswari, N. Rajini, Sanjay Mavinakere Rangappa, Masrat Rasheed, Bosko Rasuo, Naheed Saba, S.M. Sapuan, Hiroyuki Sasahara, K. Senthilkumar, Pradeep Shivanna, Ramengmawii Siakeng, Suchart Siengchin, I. Siva, Mohamed T.H. Sultan, Chad Ulven, Dean Webster, J.T. Winowlin Jappes, and Arvin Yu
- Published
- 2018
- Full Text
- View/download PDF
40. A mini review on immune role of chemokines and its receptors in snakehead murrel Channa striatus
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Bhatt, Prasanth, Kumaresan, Venkatesh, Palanisamy, Rajesh, Ravichandran, Gayathri, Mala, Kanchana, Sarker, S. M. Nurul Amin Harmuj Ali, Arshad, Aziz, Md. Yusoff, Fatimah, Arockiaraj, Jesu, Bhatt, Prasanth, Kumaresan, Venkatesh, Palanisamy, Rajesh, Ravichandran, Gayathri, Mala, Kanchana, Sarker, S. M. Nurul Amin Harmuj Ali, Arshad, Aziz, Md. Yusoff, Fatimah, and Arockiaraj, Jesu
- Abstract
Chemokines are ubiquitous cytokine molecules involved in migration of cells during inflammation and normal physiological processes. Though the study on chemokines in mammalian species like humans have been extensively studied, characterization of chemokines in teleost fishes is still in the early stage. The present review provides an overview of chemokines and its receptors in a teleost fish, Channa striatus. C. striatus is an air breathing freshwater carnivore, which has enormous economic importance. This species is affected by an oomycete fungus, Aphanomyces invadans and a Gram negative bacteria Aeromonas hydrophila is known to cause secondary infection. These pathogens impose immune changes in the host organism, which in turn mounts several immune responses. Of these, the role of cytokines in the immune response is immense, due to their involvement in several activities of inflammation such as cell trafficking to the site of inflammation and antigen presentation. Given that importance, chemokines in fishes do have significant role in the immunological and other physiological functions of the organism, hence there is a need to understand the characteristics, activities and performace of these small molecules in details.
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- 2017
41. Population and fertility by age and sex for 195 countries and territories, 1950-2017: a systematic analysis for the Global Burden of Disease Study 2017
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Murray, Christopher J L, Callender, Charlton S K H, Kulikoff, Xie Rachel, Srinivasan, Vinay, Abate, Degu, Abate, Kalkidan Hassen, Abay, Solomon M, Abbasi, Nooshin, Abbastabar, Hedayat, Abdela, Jemal, Abdelalim, Ahmed, Abdel-Rahman, Omar, Abdi, Alireza, Abdoli, Nasrin, Abdollahpour, Ibrahim, Abdulkader, Rizwan Suliankatchi, Abebe, Haftom Temesgen, Abebe, Molla, Abebe, Zegeye, Abebo, Teshome Abuka, Abejie, Ayenew Negesse, Aboyans, Victor, Abraha, Haftom Niguse, Abreu, Daisy Maria Xavier, Abrham, Aklilu Roba, Abu-Raddad, Laith Jamal, Abu-Rmeileh, Niveen M E, Accrombessi, Manfred Mario Kokou, Acharya, Pawan, Adamu, Abdu A, Adebayo, Oladimeji M, Adedeji, Isaac Akinkunmi, Adekanmbi, Victor, Adetokunboh, Olatunji O, Adhena, Beyene Meressa, Adhikari, Tara Ballav, Adib, Mina G, Adou, Arsène Kouablan, Adsuar, Jose C, Afarideh, Mohsen, Afshin, Ashkan, Agarwal, Gina, Agesa, Kareha M, Aghayan, Sargis Aghasi, Agrawal, Sutapa, Ahmadi, Alireza, Ahmadi, Mehdi, Ahmed, Muktar Beshir, Ahmed, Sayem, Aichour, Amani Nidhal, Aichour, Ibtihel, Aichour, Miloud Taki Eddine, Akanda, Ali S, Akbari, Mohammad Esmaeil, Akibu, Mohammed, Akinyemi, Rufus Olusola, Akinyemiju, Tomi, Akseer, Nadia, Alahdab, Fares, Al-Aly, Ziyad, Alam, Khurshid, Alebel, Animut, Aleman, Alicia V, Alene, Kefyalew Addis, Al-Eyadhy, Ayman, Ali, Raghib, Alijanzadeh, Mehran, Alizadeh-Navaei, Reza, Aljunid, Syed Mohamed, Alkerwi, Ala'a, Alla, François, Allebeck, Peter, Almasi, Ali, Alonso, Jordi, Al-Raddadi, Rajaa M, Alsharif, Ubai, Altirkawi, Khalid, Alvis-Guzman, Nelson, Amare, Azmeraw T, Ammar, Walid, Anber, Nahla Hamed, Andrei, Catalina Liliana, Androudi, Sofia, Animut, Megbaru Debalkie, Ansari, Hossein, Ansha, Mustafa Geleto, Antonio, Carl Abelardo T, Appiah, Seth Christopher Yaw, Aremu, Olatunde, Areri, Habtamu Abera, Arian, Nicholas, Ärnlöv, Johan, Artaman, Al, Aryal, Krishna K, Asayesh, Hamid, Asfaw, Ephrem Tsegay, Asgedom, Solomon Weldegebreal, Assadi, Reza, Atey, Tesfay Mehari Mehari, Atique, Suleman, Atteraya, Madhu Sudhan, Ausloos, Marcel, Avokpaho, Euripide F G A, Awasthi, Ashish, Ayala Quintanilla, Beatriz Paulina, Ayele, Yohanes, Ayer, Rakesh, Ayuk, Tambe B, Azzopardi, Peter S, Babalola, Tesleem Kayode, Babazadeh, Arefeh, Badali, Hamid, Badawi, Alaa, Bali, Ayele Geleto, Banach, Maciej, Barker-Collo, Suzanne Lyn, Bärnighausen, Till Winfried, Barrero, Lope H, Basaleem, Huda, Bassat, Quique, Basu, Arindam, Baune, Bernhard T, Baynes, Habtamu Wondifraw, Beghi, Ettore, Behzadifar, Masoud, Behzadifar, Meysam, Bekele, Bayu Begashaw, Belachew, Abate Bekele, Belay, Aregawi Gebreyesus, Belay, Ezra, Belay, Saba Abraham, Belay, Yihalem Abebe, Bell, Michelle L, Bello, Aminu K, Bennett, Derrick A, Bensenor, Isabela M, Bergeron, Gilles, Berhane, Adugnaw, Berman, Adam E, Bernabe, Eduardo, Bernstein, Robert S, Bertolacci, Gregory J, Beuran, Mircea, Bhattarai, Suraj, Bhaumik, Soumyadeep, Bhutta, Zulfiqar A, Biadgo, Belete, Bijani, Ali, Bikbov, Boris, Bililign, Nigus, Bin Sayeed, Muhammad Shahdaat, Birlik, Sait Mentes, Birungi, Charles, Biswas, Tuhin, Bizuneh, Hailemichael, Bleyer, Archie, Basara, Berrak Bora, Bosetti, Cristina, Boufous, Soufiane, Brady, Oliver J, Bragazzi, Nicola Luigi, Brainin, Michael, Brazinova, Alexandra, Breitborde, Nicholas J K, Brenner, Hermann, Brewer, Jerry D, Briant, Paul Svitil, Britton, Gabrielle, Burstein, Roy, Busse, Reinhard, Butt, Zahid A, Cahuana-Hurtado, Lucero, Campos-Nonato, Ismael R, Campuzano Rincon, Julio Cesar, Cano, Jorge, Car, Mate, Cárdenas, Rosario, Carrero, Juan J, Carvalho, Félix, Castañeda-Orjuela, Carlos A, Castillo Rivas, Jacqueline, Castro, Franz, Catalá-López, Ferrán, Çavlin, Alanur, Cerin, Ester, Chalek, Julian, Chang, Hsing-Yi, Chang, Jung-Chen, Chattopadhyay, Aparajita, Chaturvedi, Pankaj, Chiang, Peggy Pei-Chia, Chin, Ken Lee, Chisumpa, Vesper Hichilombwe, Chitheer, Abdulaal, Choi, Jee-Young J, Chowdhury, Rajiv, Christopher, Devasahayam J, Cicuttini, Flavia M, Ciobanu, Liliana G, Cirillo, Massimo, Claro, Rafael M, Collado-Mateo, Daniel, Constantin, Maria-Magdalena, Conti, Sara, Cooper, Cyrus, Cooper, Leslie Trumbull, Cornaby, Leslie, Cortesi, Paolo Angelo, Cortinovis, Monica, Costa, Megan, Cromwell, Elizabeth, Crowe, Christopher Stephen, Cukelj, Petra, Cunningham, Matthew, Daba, Alemneh Kabeta, Dachew, Berihun Assefa, Dandona, Lalit, Dandona, Rakhi, Dargan, Paul I, Daryani, Ahmad, Das Gupta, Rajat, Das Neves, José, Dasa, Tamirat Tesfaye, Dash, Aditya Prasad, Weaver, Nicole Davis, Davitoiu, Dragos Virgil, Davletov, Kairat, De Leo, Diego, De Neve, Jan-Walter, Degefa, Meaza Girma, Degenhardt, Louisa, Degfie, Tizta Tilahun, Deiparine, Selina, Demoz, Gebre Teklemariam, Demtsu, Balem, Denova-Gutiérrez, Edgar, Deribe, Kebede, Dervenis, Nikolaos, Des Jarlais, Don C, Dessie, Getenet Ayalew, Dharmaratne, Samath D, Dhimal, Meghnath, Dicker, Daniel, Ding, Eric L, Dinsa, Girmaye Deye, Djalalinia, Shirin, Do, Huyen Phuc, Dokova, Klara, Doku, David Teye, Dolan, Kate A, Doyle, Kerrie E, Driscoll, Tim R, Dubey, Manisha, Dubljanin, Eleonora, Duken, Eyasu Ejeta, Duraes, Andre R, Ebrahimpour, Soheil, Edvardsson, David, El Bcheraoui, Charbel, El-Khatib, Ziad, Elyazar, Iqbal Rf, Enayati, Ahmadali, Endries, Aman Yesuf, Ermakov, Sergey Petrovich, Eshrati, Babak, Eskandarieh, Sharareh, Esmaeili, Reza, Esteghamati, Alireza, Esteghamati, Sadaf, Estep, Kara, Fakhim, Hamed, Farag, Tamer, Faramarzi, Mahbobeh, Fareed, Mohammad, Farinha, Carla Sofia E Sá, Faro, Andre, Farvid, Maryam S, Farzadfar, Farshad, Farzaei, Mohammad Hosein, Fay, Kairsten A, Fazeli, Mir Sohail, Feigin, Valery L, Feigl, Andrea B, Feizy, Fariba, Fenny, Ama P, Fentahun, Netsanet, Fereshtehnejad, Seyed-Mohammad, Fernandes, Eduarda, Feyissa, Garumma Tolu, Filip, Irina, Finegold, Samuel, Fischer, Florian, Flor, Luisa Sorio, Foigt, Nataliya A, Foreman, Kyle J, Fornari, Carla, Fürst, Thomas, Fukumoto, Takeshi, Fuller, John E, Fullman, Nancy, Gakidou, Emmanuela, Gallus, Silvano, Gamkrelidze, Amiran, Ganji, Morsaleh, Gankpe, Fortune Gbetoho, Garcia, 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Sudhir Kumar, Jakovljevic, Mihajlo, Jalu, Moti Tolera, James, Spencer L, Jassal, Simerjot K, Javanbakht, Mehdi, Jayatilleke, Achala Upendra, Jeemon, Panniyammakal, Jha, Ravi Prakash, Jha, Vivekanand, Ji, John S, Jonas, Jost B, Jozwiak, Jacek Jerzy, Jungari, Suresh Banayya, Jürisson, Mikk, Kabir, Zubair, Kadel, Rajendra, Kahsay, Amaha, Kalani, Rizwan, Kapil, Umesh, Karami, Manoochehr, Matin, Behzad Karami, Karch, André, Karema, Corine, Karimi, Seyed M, Kasaeian, Amir, Kassa, Dessalegn H, Kassa, Getachew Mullu, Kassa, Tesfaye Dessale, Kassa, Zemenu Yohannes, Kassebaum, Nicholas J, Kastor, Anshul, Katikireddi, Srinivasa Vittal, Kaul, Anil, Kawakami, Norito, Karyani, Ali Kazemi, Kebede, Seifu, Keiyoro, Peter Njenga, Kemp, Grant Rodgers, Kengne, Andre Pascal, Keren, Andre, Kereselidze, Maia, Khader, Yousef Saleh, Khafaie, Morteza Abdullatif, Khajavi, Alireza, Khalid, Nauman, Khalil, Ibrahim A, Khan, Ejaz Ahmad, Khan, Muhammad Shahzeb, Khang, Young-Ho, Khanna, Tripti, Khater, Mona M, 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Vasconcelos, A, Vladimirov, S, Vollset, S, Walson, J, Weintraub, R, Weldegwergs, K, Wolfe, C, Wyper, G, Yasin, Y, Yentür, G, Yimer, E, Yoon, S, Younis, M, Zaman, S, Zeleke, M, Zenebe, Z, Zerfu, T, Zhao, X, Zimsen, S, Lopez, A, and Lim, S
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Adult ,Male ,Population Density ,GBD, population, fertility ,Adolescent ,Medicine (all) ,Infant, Newborn ,Infant ,11 Medical And Health Sciences ,Middle Aged ,Global Health ,Global Burden of Disease ,Young Adult ,Child, Preschool ,General & Internal Medicine ,Female ,Human medicine ,Mortality ,Child ,Population Growth ,Birth Rate ,Aged ,Human ,Maternal Age - Abstract
Background Population estimates underpin demographic and epidemiological research and are used to track progress on numerous international indicators of health and development. To date, internationally available estimates of population and fertility, although useful, have not been produced with transparent and replicable methods and do not use standardised estimates of mortality. We present single-calendar year and single-year of age estimates of fertility and population by sex with standardised and replicable methods. Methods We estimated population in 195 locations by single year of age and single calendar year from 1950 to 2017 with standardised and replicable methods. We based the estimates on the demographic balancing equation, with inputs of fertility, mortality, population, and migration data. Fertility data came from 7817 location-years of vital registration data, 429 surveys reporting complete birth histories, and 977 surveys and censuses reporting summary birth histories. We estimated age-specific fertility rates (ASFRs; the annual number of livebirths to women of a specified age group per 1000 women in that age group) by use of spatiotemporal Gaussian process regression and used the ASFRs to estimate total fertility rates (TFRs; the average number of children a woman would bear if she survived through the end of the reproductive age span [age 10-54 years] and experienced at each age a particular set of ASFRs observed in the year of interest). Because of sparse data, fertility at ages 10-14 years and 50-54 years was estimated from data on fertility in women aged 15-19 years and 45-49 years, through use of linear regression. Age-specific mortality data came from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2017 estimates. Data on population came from 1257 censuses and 761 population registry location-years and were adjusted for underenumeration and age misreporting with standard demographic methods. Migration was estimated with the GBD Bayesian demographic balancing model, after incorporating information about refugee migration into the model prior. Final population estimates used the cohort-cotnponent method of population projection, with inputs of fertility, mortality, and migration data. Population uncertainty was estimated by use of out-of-sample predictive validity testing. With these data, we estimated the trends in population by age and sex and in fertility by age between 1950 and 2017 in 195 countries and territories. Findings From 1950 to 2017, TFRs decreased by 49.4% (95% uncertainty interval [UI] 46.4-52.0). The TFR decreased from 4.7 livebirths (4.5-4.9) to 2.4 livebirths (2.2-2.5), and the ASFR of mothers aged 10-19 years decreased from 37 livebirths (34-40) to 22 livebirths (19-24) per 1000 women. Despite reductions in the TFR, the global population has been increasing by an average of 83.8 million people per year since 1985. The global population increased by 197-2% (193.3-200.8) since 1950, from 2.6 billion (2.5-2.6) to 7.6 billion (7.4-7.9) people in 2017; much of this increase was in the proportion of the global population in south Asia and sub-Saharan Africa. The global annual rate of population growth increased between 1950 and 1964, when it peaked at 2.0%; this rate then remained nearly constant until 1970 and then decreased to 1.1% in 2017. Population growth rates in the southeast Asia, east Asia, and Oceania GBD super-region decreased from 2.5% in 1963 to O7% in 2017, whereas in sub-Saharan Africa, population growth rates were almost at the highest reported levels ever in 2017, when they were at 2.7%. The global average age increased from 26.6 years in 1950 to 32.1 years in 2017, and the proportion of the population that is of working age (age 15-64 years) increased from 59.9% to 65.3%. At the national level, the TFR decreased in all countries and territories between 1950 and 2017; in 2017, TFRs ranged from a low of 1.0 livebirths (95% UI 0. 9-1.2) in Cyprus to a high of 7.1 livebirths (6.8-7.4) in Niger. The TFR under age 25 years (TFU25; number of livebirths expected by age 25 years for a hypothetical woman who survived the age group and was exposed to current ASFRs) in 2017 ranged from 0.08 livebirths (0.07-0.09) in South Korea to 2.4 livebirths (2.2-2.6) in Niger, and the TFR over age 30 years (I F030; number of livebirths expected for a hypothetical woman ageing from 30 to 54 years who survived the age group and was exposed to current ASFRs) ranged from a low of 0.3 livebirths (0.3-0-4) in Puerto Rico to a high of 3.1 livebirths (3.0-3.2) in Niger. TF030 was higher than TFU25 in 145 countries and territories in 2017.33 countries had a negative population growth rate from 2010 to 2017, most of which were located in central, eastern, and western Europe, whereas population growth rates of more than 2.0% were seen in 33 of 46 countries in sub-Saharan Africa. In 2017, less than 65% of the national population was of working age in 12 of 34 high-income countries, and less than 50% of the national population was of working age in Mali, Chad, and Niger. Interpretation Population trends create demographic dividends and headwinds (ie, economic benefits and detriments) that affect national economies and determine national planning needs. Although TFRs are decreasing, the global population continues to grow as mortality declines, with diverse patterns at the national level and across age groups. To our knowledge, this is the first study to provide transparent and replicable estimates of population and fertility, which can be used to inform decision making and to monitor progress. Copyright (C) 2018 The Author(s). Published by Elsevier Ltd.
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42. Search for a non-standard-model Higgs boson decaying to a pair of new light bosons in four-muon final states
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Scarborough, Michail Bachtis, Hamish Silverwood, Christian Barth, Daniele Fasanella, Duncan Carlsmith, Robert Hirosky, Paul Kyberd, Andrea Venturi, G. Hamel de Monchenault, R. Schmidt, Piet Verwilligen, Stefan Spanier, Brian Dorney, Mariarosaria D'Alfonso, Mario Galanti, Kumar Arun Kumar, Zoltan Szillasi, R. Beuselinck, Zijin Guo, T. R. Fernandez Perez Tomei, E. Alagoz, Andrey Uzunian, Christopher Palmer, V. Dero, Alice Bean, Balazs Ujvari, Yuri Musienko, Shervin Nourbakhsh, Lukas Vanelderen, Ivan-Kresimir Furic, Rishi Patel, Min Suk Kim, Vipin Bhatnagar, Danilo Piparo, Leonid Tourtchanovitch, Kristen Flowers, Clara Jorda, J. Sammet, Eleni Ntomari, Paolo Rumerio, Lorenzo Uplegger, William T. Ford, Christian Autermann, Jacob Ribnik, D. Lazic, Kenneth Bloom, Harold Nguyen, M. De Mattia, Nasuf Sonmez, Lamia Benhabib, Hannsjoerg Artur Weber, Gordon H. Hanson, Geonmo Ryu, Pramod Lamichhane, Hongfang Liu, Subir Sarkar, Andrey Ostapchuk, M. J. 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Tabarelli de Fatis, Frederic Jean Ronga, Kevin Burkett, N. Srimanobhas, Lalit Mohan Pant, Aaron Dominguez, Abdollah Mohammadi, Demetrios Loukas, Mikhail Makouski, Laurent Forthomme, Ludwig Tauscher, Jordan Nash, Sung Keun Park, W. Martin, M. Cardaci, J. M. Vizan Garcia, Bugra Bilin, Kati Lassila-Perini, Petra Merkel, Pelin Kurt, Felicitas Pauss, Si Xie, Jang D.W Jang, Robert Stone, J. Palinkas, Frank Meier, Nicolas Zaganidis, Yang Yang, Paolo Giacomelli, Shin-Shan Yu, Matthew Jones, Alexei Raspereza, Geoffrey Hall, Sanjay Padhi, J. S. Keller, Salvatore Nuzzo, Anton Volodko, S. Bilmis, Philippe Bloch, A. F. Osorio Oliveros, R. Houtz, Aniello Nappi, C. De Oliveira Martins, Victor Golovtsov, Sh. Jain, Robert Fischer, Wee Don Teo, Panagiotis Kokkas, Lorenzo Bianchini, Maksym Titov, Alexander Vinogradov, Herbert Rohringer, Federico Ferri, Douglas Berry, R. Sever, Igor Azhgirey, Frank Golf, M. Boutemeur, Edward Laird, Vieri Candelise, Ted Kolberg, Yossof Eshaq, M. A. Shah, A. Everett, Claude Charlot, Burton Betchart, Tim Bolton, Giuseppe Iaselli, Alberto Potenza, Georgi Sultanov, David Cutts, Kevin Stenson, D. Cline, Achim Stahl, G. P. Di Giovanni, M. Mohammadi Najafabadi, Daniel Troendle, Panja-Riina Luukka, Roberto Salerno, Olga Kodolova, Bora Isildak, Riccardo Travaglini, D. Gerbaudo, W. Kiesenhofer, Antony Adair, Stefano Mersi, A. T. Laasanen, Mihee Jo, G. Merino, G. Vander Marcken, Ege Üniversitesi, CMS Collaboration, Physics, Elementary Particle Physics, Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Laboratoire Leprince-Ringuet (LLR), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Département Recherches Subatomiques (DRS-IPHC), Institut Pluridisciplinaire Hubert Curien (IPHC), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Centre de Calcul de l'IN2P3 (CC-IN2P3), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut de Physique Nucléaire de Lyon (IPNL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), CMS, Chatrchyan, S, Khachatryan, V, Sirunyan, A, Tumasyan, A, Adam, W, Aguilo, E, Bergauer, T, Dragicevic, M, Erö, J, Fabjan, C, Friedl, M, Frühwirth, R, Ghete, V, Hammer, J, Hörmann, N, Hrubec, J, Jeitler, M, Kiesenhofer, W, Knünz, V, Krammer, M, Krätschmer, I, Liko, D, Mikulec, I, Pernicka, M, Rahbaran, B, Rohringer, C, Rohringer, H, Schöfbeck, R, Strauss, J, Taurok, A, Waltenberger, W, Walzel, G, Widl, E, Wulz, C, Mossolov, V, Shumeiko, N, Suarez Gonzalez, J, Bansal, M, Bansal, S, Cornelis, T, De Wolf, E, Janssen, X, Luyckx, S, Mucibello, L, Ochesanu, S, Roland, B, Rougny, R, Selvaggi, M, Staykova, Z, Van Haevermaet, H, Van Mechelen, P, Van Remortel, N, Van Spilbeeck, A, Blekman, F, Blyweert, S, D'Hondt, J, Gonzalez Suarez, R, Kalogeropoulos, A, Maes, M, Olbrechts, A, Van Doninck, W, Van Mulders, P, Van Onsem, G, Villella, I, Clerbaux, B, De Lentdecker, G, Dero, V, Gay, A, Hreus, T, Léonard, A, Marage, P, Mohammadi, A, Reis, T, Thomas, L, Vander Marcken, G, Vander Velde, C, Vanlaer, P, Wang, J, Adler, V, Beernaert, K, Cimmino, A, Costantini, S, Garcia, G, Grunewald, M, Klein, B, Lellouch, J, Marinov, A, Mccartin, J, Ocampo Rios, A, Ryckbosch, D, Strobbe, N, Thyssen, F, Tytgat, M, Verwilligen, P, Walsh, S, Yazgan, E, Zaganidis, N, Basegmez, S, Bruno, G, Castello, R, Ceard, L, Delaere, C, du Pree, T, Favart, D, Forthomme, L, Giammanco, A, Hollar, J, Lemaitre, V, Liao, J, Militaru, O, Nuttens, C, Pagano, D, Pin, A, Piotrzkowski, K, Schul, N, Vizan Garcia, J, Beliy, N, Caebergs, T, Daubie, E, Hammad, G, Alves, G, Correa Martins Junior, M, Martins, T, Pol, M, Souza, M, Aldá Júnior, W, Carvalho, W, Custódio, A, Da Costa, E, De Jesus Damiao, D, De Oliveira Martins, C, Fonseca De Souza, S, Matos Figueiredo, D, Mundim, L, Nogima, H, Oguri, V, Prado Da Silva, W, Santoro, A, L. 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Swanson, The, CMS Collaboration, Iorio, ALBERTO ORSO MARIA, Others, Merola, Mario, Lista, Luca, Belforte, S., Candelise, Vieri, Casarsa, M., Cossutti, F., DELLA RICCA, Giuseppe, Gobbo, B., Marone, Matteo, Montanino, Damiana, Penzo, A., Schizzi, Andrea, Çukurova Üniversitesi, Fen-Edebiyat Fakültesi, Fizik Bölümü, Özyeğin University, Işıldak, Bora, Yerevan Phys Inst, OeAW, Natl Ctr Particle & High Energy Phys, Univ Antwerp, Vrije Univ Brussel, Univ Libre Brussels, Univ Ghent, Catholic Univ Louvain, Univ Mons, Centro Brasileiro de Pesquisas Físicas (CBPF), Universidade do Estado do Rio de Janeiro (UERJ), Universidade Estadual Paulista (Unesp), Bulgarian Acad Sci, Univ Sofia, Inst High Energy Phys, Peking Univ, Universidad de los Andes, Tech Univ Split, Univ Split, Rudjer Boskovic Inst, Univ Cyprus, Charles Univ Prague, Acad Sci Res & Technol Arab Republ Egypt, NICPB, Univ Helsinki, Helsinki Inst Phys, Lappeenranta Univ Technol, CEA Saclay, Ecole Polytech, Univ Haute Alsace Mulhouse, CNRS, Univ Lyon 1, Tbilisi State Univ, RWTH Aachen University, DESY, Univ Hamburg, Univ Karlsruhe, Inst Nucl Phys Demokritos, Univ Athens, Univ Ioannina, KFKI Res Inst Particle & Nucl Phys, Inst Nucl Res ATOMKI, Debrecen Univ Med, Panjab Univ, University of Delhi, Saha Inst Nucl Phys, Bhabha Atom Res Ctr, Tata Inst Fundamental Res EHEP, Tata Inst Fundamental Res HECR, Inst Res Fundamental Sci IPM, Ist Nazl Fis Nucl, Univ Bari, Politecn Bari, Univ Bologna, Univ Catania, Univ Florence, Univ Genoa, Univ Milano Bicocca, Univ Naples Federico II, Univ Padua, Univ Trento Trento, Univ Pavia, Univ Perugia, Univ Pisa, Scuola Normale Super Pisa, Univ Rome, Univ Turin, Univ Piemonte Orientale Novara, Univ Trieste, Kangwon Natl Univ, Kyungpook Natl Univ, Chonnam Natl Univ, Korea University, Univ Seoul, Sungkyunkwan Univ, Vilnius State Univ, IPN, Univ Iberoamer, Benemerita Univ Autonoma Puebla, Univ Autonoma San Luis Potosi, Univ Auckland, Univ Canterbury, Quaid I Azam Univ, Natl Ctr Nucl Res, Univ Warsaw, Lab Instrumentacao & Fis Expt Particulas, Joint Inst Nucl Res, Petersburg Nucl Phys Inst, Russian Acad Sci, Institute for Theoretical and Experimental Physics (ITEP), Moscow MV Lomonosov State Univ, PN Lebedev Phys Inst, State Res Ctr Russian Federat, University of Belgrade, Vinca Inst Nucl Sci, CIEMAT, Univ Autonoma Madrid, Univ Oviedo, Univ Cantabria, CERN, Paul Scherrer Inst, Swiss Fed Inst Technol, Univ Zurich, Natl Cent Univ, Natl Taiwan Univ, Chulalongkorn Univ, Cukurova Univ, Middle E Tech Univ, Bogazici Univ, Istanbul Tech Univ, Natl Sci Ctr, Univ Bristol, Rutherford Appleton Lab, Univ London Imperial Coll Sci Technol & Med, Brunel Univ, Baylor Univ, Univ Alabama, Boston University, Brown University, Univ Calif Davis, Univ Calif Los Angeles, University of California, Riverside (UCR), Univ Calif San Diego, Univ Calif Santa Barbara, CALTECH, Carnegie Mellon Univ, Univ Colorado, Cornell Univ, Fairfield Univ, Fermilab Natl Accelerator Lab, Univ Florida, Florida Int Univ, Florida State University, Florida Inst Technol, Univ Illinois, Univ Iowa, Johns Hopkins Univ, University of Kansas (KU), Kansas State University, Lawrence Livermore Natl Lab, University of Maryland, MIT, Univ Minnesota, University of Mississippi, Univ Nebraska, SUNY Buffalo, Northeastern University, Northwestern University (NU), Univ Notre Dame, Ohio State Univ, Princeton University, Univ Puerto Rico, Purdue Univ, Purdue University Calumet, Rice University, University of Rochester, Rockefeller Univ, Rutgers State Univ, Univ Tennessee, Texas A&M Univ, Texas Tech Univ, Vanderbilt Univ, University of Virginia (UVA), Wayne State Univ, Univ Wisconsin, Vienna Univ Technol, Universidade Federal do ABC (UFABC), Suez Canal Univ, Zewail City Sci & Technol, Cairo Univ, Fayoum Univ, British Univ Egypt, Univ Haute Alsace, Brandenburg Tech Univ Cottbus, Eotvos Lorand Univ, Visva Bharati Univ, Sharif Univ Technol, Isfahan Univ Technol, Islamic Azad Univ, Univ Basilicata, Univ Guglielmo Marconi, Univ Siena, Univ Bucharest, Sezione Ist Nazl Fis Nucl, Albert Einstein Ctr Fundamental Phys, Gaziosmanpasa Univ, Adiyaman Univ, Izmir Inst Technol, Mersin Univ, Ozyegin Univ, Kafkas Univ, Suleyman Demirel Univ, Ege Univ, Univ Southampton, Univ Sydney, Utah Valley Univ, Argonne Natl Lab, Erzincan Univ, Mimar Sinan Univ, Karapınar, Güler, Izmir Institute of Technology. Mathematics, Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Université de Strasbourg (UNISTRA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), CMS Collaboration (ukupan broj autora: 2198), UCL - SST/IRMP - Institut de recherche en mathématique et physique, S., Chatrchyan, V., Khachatryan, A. M., Sirunyan, A., Tumasyan, W., Adam, E., Aguilo, T., Bergauer, M., Dragicevic, J., Ero, C., Fabjan, M., Friedl, R., Fruhwirth, V. M., Ghete, J., Hammer, N., Hormann, J., Hrubec, M., Jeitler, W., Kiesenhofer, V., Knunz, M., Krammer, I., Kratschmer, D., Liko, I., Mikulec, M., Pernicka, B., Rahbaran, C., Rohringer, H., Rohringer, R., Schofbeck, J., Strau, A., Taurok, W., Waltenberger, G., Walzel, E., Widl, C. E., Wulz, V., Mossolov, N., Shumeiko, J. S., Gonzalez, M., Bansal, S., Bansal, T., Corneli, E. A., De, X., Janssen, S., Luyckx, L., Mucibello, S., Ochesanu, B., Roland, R., Rougny, M., Selvaggi, Z., Staykova, H. V., Haevermaet, P. V., Mechelen, N. V., Remortel, A. V., Spilbeeck, F., Blekman, S., Blyweert, J., D'Hondt, R. G., Suarez, A., Kalogeropoulo, M., Mae, A., Olbrecht, W. V., Doninck, P. V., Mulder, G. P., Van, I., Villella, B., Clerbaux, G. D., Lentdecker, V., Dero, A. P., R., T., Hreu, A., Leonard, P. E., Marage, A., Mohammadi, T., Rei, L., Thoma, G. V., Marcken, C. V., Velde, P., Vanlaer, J., Wang, V., Adler, K., Beernaert, A., Cimmino, S., Costantini, G., Garcia, M., Grunewald, B., Klein, J., Lellouch, A., Marinov, J., Mccartin, A. A., O., D., Ryckbosch, N., Strobbe, F., Thyssen, M., Tytgat, P., Verwilligen, S., Walsh, E., Yazgan, N., Zaganidi, S., Basegmez, G., Bruno, R., Castello, L., Ceard, C., Delaere, T. d., Pree, D., Favart, L., Forthomme, A., Giammanco, J., Hollar, V., Lemaitre, J., Liao, O., Militaru, C., Nutten, D., Pagano, A., Pin, K., Piotrzkowski, N., Schul, J. M., V., N., Beliy, T., Caeberg, E., Daubie, G. H., Hammad, G. A., Alve, M. C., Martin, T., Martin, M. E., Pol, M. H., G., W. L., Alda, W., Carvalho, A., Custodio, E. M., Da, D. D., Damiao, C. D., Martin, S. F., De, D. M., Figueiredo, L., Mundim, H., Nogima, V., Oguri, W. L., P., A., Santoro, L. S., Jorge, A., Sznajder, T. S., Anjo, C. A., Bernarde, F. A., Dia, T. R., F., E. M., Gregore, C., Lagana, F., Marinho, P. G., Mercadante, S. F., Novae, S. S., Padula, V., Genchev, P., Iaydjiev, S., Piperov, M., Rodozov, S., Stoykova, G., Sultanov, V., Tcholakov, R., Trayanov, M., Vutova, A., Dimitrov, R., Hadjiiska, V., Kozhuharov, L., Litov, B., Pavlov, P., Petkov, J. G., Bian, G. M., Chen, H. S., Chen, C. H., Jiang, D., Liang, S., Liang, X., Meng, J., Tao, X., Wang, Z., Wang, H., Xiao, M., Xu, J., Zang, Z., Zhang, C., Asawatangtrakuldee, Y., Ban, Y., Guo, W., Li, S., Liu, Y., Mao, S. J., Qian, H., Teng, D., Wang, L., Zhang, W., Zou, C., Avila, J. P., Gomez, B. G., Moreno, A. F., O., J. C., Sanabria, N., Godinovic, D., Lela, R., Plestina, D., Polic, I., Puljak, Z., Antunovic, M., Kovac, V., Brigljevic, S., Duric, K., Kadija, J., Luetic, S., Morovic, A., Attiki, M., Galanti, G., Mavromanolaki, J., Mousa, C., Nicolaou, F., Ptocho, P. A., Razi, M., Finger, Y., Assran, S., Elgammal, A. E., Kamel, M. 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L., Agram, J., Andrea, D., Bloch, D., Bodin, J. M., Brom, M., Cardaci, E. C., Chabert, C., Collard, E., Conte, F., Drouhin, C., Ferro, J. C., Fontaine, D., Gele, U., Goerlach, P., Juillot, A. C., Le, P. V., Hove, F., Fassi, D., Mercier, S., Beauceron, N., Beaupere, O., Bondu, G., Boudoul, J., Chasserat, R., Chierici, D., Contardo, P., Depasse, H. 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A., Martin, J., Behr, W., Behrenhoff, U., Behren, M., Bergholz, A., Bethani, K., Borra, A., Burgmeier, A., Cakir, L., Calligari, A., Campbell, E., Castro, F., Costanza, D., Dammann, C. D., Pardo, G., Eckerlin, D., Eckstein, G., Flucke, A., Geiser, I., Glushkov, P., Gunnellini, S., Habib, J., Hauk, G., Hellwig, H., Jung, M., Kasemann, P., Katsa, C., Kleinwort, H., Kluge, A., Knutsson, M., Kramer, D., Krucker, E., Kuznetsova, W., Lange, W., Lohmann, B., Lutz, R., Mankel, I., Marfin, M., Marienfeld, I. A., Melzer Pellmann, A. B., Meyer, J., Mnich, A., Mussgiller, S., Naumann Emme, O., Novgorodova, J., Olzem, H., Perrey, A., Petrukhin, D., Pitzl, A., Raspereza, P. M., R., C., Riedl, E., Ron, M., Rosin, J., Salfeld Nebgen, R., Schmidt, T., Schoerner Sadeniu, N., Sen, A., Spiridonov, M., Stein, R., Walsh, C., Wissing, V., Blobel, J., Draeger, H., Enderle, J., Erfle, U., Gebbert, M., Gorner, T., Hermann, R. S., Hoing, K., Kaschube, G., Kaussen, H., Kirschenmann, R., Klanner, J., Lange, B., Mura, F., Nowak, T., Peiffer, N., Pietsch, D., Rathjen, C., Sander, H., Schettler, P., Schleper, E., Schlieckau, A., Schmidt, M., Schroder, T., Schum, M., Seidel, J., Sibille, V., Sola, H., Stadie, G., Steinbruck, J., Thomsen, L., Vanelderen, C., Barth, J., Berger, C., Boser, T., Chwalek, W. D., Boer, A., Descroix, A., Dierlamm, M., Feindt, M., Guthoff, C., Hackstein, F., Hartmann, T., Hauth, M., Heinrich, H., Held, K. H., Hoffmann, U., Husemann, I., Katkov, J. R., Komaragiri, P. L., Pardo, D., Martschei, S., Mueller, T., Muller, M., Niegel, A., Nurnberg, O., Oberst, A., Oehler, J., Ott, G., Quast, K., Rabbertz, F., Ratnikov, N., Ratnikova, S., Rocker, F. P., Schilling, G., Schott, H. J., Simoni, F. M., Stober, D., Troendle, R., Ulrich, J., Wagner Kuhr, S., Wayand, T., Weiler, M., Zeise, G., Daskalaki, T., Gerali, S., Kesisoglou, A., Kyriaki, D., Louka, I., Manolako, A., Markou, C., Markou, C., Mavrommati, E., Ntomari, L., Gousko, T. J., Mertzimeki, A., Panagiotou, N., Saoulidou, I., Evangelou, C., Fouda, P., Kokka, N., Mantho, I., Papadopoulo, V., Patra, G., Bencze, C., Hajdu, P., Hida, D., Horvath, F., Sikler, V., Veszpremi, G., Vesztergombi, N., Beni, S., Czellar, J., Molnar, J., Palinka, Z., Szillasi, J., Karancsi, P., Raic, Z. L., Trocsanyi, B., Ujvari, S. B., Beri, V., Bhatnagar, N., Dhingra, R., Gupta, M., Kaur, M. Z., Mehta, N., Nishu, L. K., Saini, A., Sharma, J. B., Singh, A., Kumar, S., Ahuja, A., Bhardwaj, B. C., Choudhary, S., Malhotra, M., Naimuddin, K., Ranjan, V., Sharma, R. K., Shivpuri, S., Banerjee, S., Bhattacharya, S., Dutta, B., Gomber, S., Jain, R., Khurana, S., Sarkar, M., Sharan, A., Abdulsalam, R. K., Choudhury, D., Dutta, S., Kaila, V., Kumar, P., Mehta, A. K., Mohanty, L. M., Pant, P., Shukla, T., Aziz, S., Ganguly, M., Guchait, M., Maity, G., Majumder, K., Mazumdar, G. B., Mohanty, B., Parida, K., Sudhakar, N., Wickramage, S., Dugad, H., Arfaei, H., Bakhshiansohi, S. M., Etesami, A., Fahim, M., Hashemi, H., Hesari, A., Jafari, M., Khakzad, M. M., Najafabadi, S. P., Mehdiabadi, B., Safarzadeh, M., Zeinali, M., Abbrescia, L., Barbone, C., Calabria, S. S., Chhibra, A., Colaleo, D., Creanza, N. D., Filippi, M. D., Palma, L., Fiore, G., Iaselli, G., Maggi, M., Maggi, B., Marangelli, S., My, S., Nuzzo, N., Pacifico, A., Pompili, G., Pugliese, G., Selvaggi, L., Silvestri, G., Singh, R., Venditti, G., Zito, G., Abbiendi, A. C., Benvenuti, D., Bonacorsi, S., Braibant Giacomelli, L., Brigliadori, P., Capiluppi, A., Castro, F. R., Cavallo, M., Cuffiani, G. M., Dallavalle, F., Fabbri, A., Fanfani, D., Fasanella, P., Giacomelli, C., Grandi, L., Guiducci, S., Marcellini, G., Masetti, M., Meneghelli, A., Montanari, F. L., Navarria, F., Odorici, A., Perrotta, F., Primavera, A. M., Rossi, T., Rovelli, G. P., Siroli, R., Travaglini, S., Albergo, G., Cappello, M., Chiorboli, S., Costa, R., Potenza, A., Tricomi, C., Tuve, G., Barbagli, V., Ciulli, C., Civinini, R., D'Alessandro, E., Focardi, S., Frosali, E., Gallo, S., Gonzi, M., Meschini, S., Paoletti, G., Sguazzoni, A., Tropiano, L., Benussi, S., Bianco, S., Colafranceschi, D., Piccolo, P., Fabbricatore, R., Musenich, S., Tosi, A., Benaglia, F. D., Guio, L. D., Matteo, S., Fiorendi, S., Gennai, A., Ghezzi, S., Malvezzi, R. A., Manzoni, A., Martelli, A., Massironi, D., Menasce, L., Moroni, M., Paganoni, D., Pedrini, S., Ragazzi, N., Redaelli, S., Sala, T. T., De, S., Buontempo, C. A., C., N., Cavallo, A. D., Cosa, O., Dogangun, F., Fabozzi, A. O., M., L., Lista, S., Meola, M., Merola, P., Paolucci, P., Azzi, N., Bacchetta, D., Bisello, A., Branca, R., Carlin, P., Checchia, T., Dorigo, F., Gasparini, U., Gasparini, A., Gozzelino, K., Kanishchev, S., Lacaprara, I., Lazzizzera, M., Margoni, A. T., Meneguzzo, M., Passaseo, J., Pazzini, M., Pegoraro, N., Pozzobon, P., Ronchese, F., Simonetto, E., Torassa, M., Tosi, S., Vanini, P., Zotto, M., Gabusi, S. P., Ratti, C., Riccardi, P., Torre, P., Vitulo, M., Biasini, G. M., Bilei, L., Fano, P., Lariccia, G., Mantovani, M., Menichelli, A., Nappi, F., Romeo, A., Saha, A., Santocchia, A., Spiezia, S., Taroni, P., Azzurri, G., Bagliesi, J., Bernardini, T., Boccali, G., Broccolo, R., Castaldi, R. T., D'Agnolo, R., Dell'Orso, F., Fiori, L., Foa, A., Giassi, A., Kraan, Ligabue, Franco, T., Lomtadze, L., Martini, A., Messineo, F., Palla, A., Rizzi, A. T., Serban, P., Spagnolo, P., Squillacioti, R., Tenchini, G., Tonelli, A., Venturi, P. G., Verdini, L., Barone, F., Cavallari, D. D., Re, M., Diemoz, C., Fanelli, M., Grassi, E., Longo, P., Meridiani, F., Micheli, S., Nourbakhsh, G., Organtini, R., Paramatti, S., Rahatlou, M., Sigamani, L., Soffi, N., Amapane, R., Arcidiacono, S., Argiro, M., Arneodo, C., Biino, N., Cartiglia, M., Costa, N., Demaria, C., Mariotti, S., Maselli, E., Migliore, V., Monaco, M., Musich, M. M., Obertino, N., Pastrone, M., Pelliccioni, A., Potenza, A., Romero, M., Ruspa, R., Sacchi, A., Solano, A., Staiano, A. V., Pereira, S., Belforte, V., Candelise, M., Casarsa, F., Cossutti, G. D., Ricca, B., Gobbo, M., Marone, D., Montanino, A., Penzo, A., Schizzi, S. G., Heo, T. Y., Kim, S. K., Nam, S., Chang, D. H., Kim, G. N., Kim, D. J., Kong, H., Park, S. R., Ro, D. C., Son, T., Son, J. Y., Kim, Z. J., Kim, S., Song, S., Choi, D., Gyun, B., Hong, M., Jo, H., Kim, T. J., Kim, K. S., Lee, D. H., Moon, S. K., Park, M., Choi, J. H., Kim, C., Park, I. C., Park, S., Park, G., Ryu, Y., Cho, Y., Choi, Y. K., Choi, J., Goh, M. S., Kim, E., Kwon, B., Lee, J., Lee, S., Lee, H., Seo, I., Yu, M. J., Bilinska, I., Grigelioni, M., Januli, A., Juodagalvi, H., Castilla Valdez, E. D., La, I. H., La, R., Lopez Fernandez, R. M., Villalba, J., Martinez Ortega, A., Sanchez Hernandez, L. M., Villasenor Cendeja, S. C., Moreno, F. V., Valencia, H. A., S., E. C., Linare, A. M., Pineda, M. A., Reyes Santo, D., Krofcheck, A. J., Bell, P. H., Butler, R., Doesburg, S., Reucroft, H., Silverwood, M., Ahmad, M. H., Ansari, M. I., Asghar, J., Butt, H. R., Hoorani, S., Khalid, W. A., Khan, T., Khurshid, S., Qazi, M. A., Shah, M., Shoaib, H., Bialkowska, B., Boimska, T., Frueboe, R., Gokieli, M., Gorski, M., Kazana, K., Nawrocki, K., Romanowska Rybinska, M., Szleper, G., Wrochna, P., Zalewski, G., Brona, K., Bunkowski, M., Cwiok, W., Dominik, K., Doroba, A., Kalinowski, M., Konecki, J., Krolikowski, N., Almeida, P., Bargassa, A., David, P., Faccioli, P. 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M., Harri, J., Hirschauer, B., Hooberman, S., Jindariani, M., Johnson, U., Joshi, B., Kilminster, B., Klima, S., Kunori, S., Kwan, C., Leonidopoulo, J., Linacre, D., Lincoln, R., Lipton, J., Lykken, K., Maeshima, J. M., Marraffino, S., Maruyama, D., Mason, P., Mcbride, K., Mishra, S., Mrenna, Y., Musienko, C., Newman Holme, V., O'Dell, O., Prokofyev, E., Sexton Kennedy, S., Sharma, W. J., Spalding, L., Spiegel, L., Taylor, S., Tkaczyk, N. V., Tran, L., Uplegger, E. W., Vaandering, R., Vidal, J., Whitmore, W., Wu, F., Yang, F., Yumiceva, J. C., Yun, D., Acosta, P., Avery, D., Bourilkov, M., Chen, T., Cheng, S., Da, M. D., Gruttola, G. P., Di, D., Dobur, A., Drozdetskiy, R. D., Field, M., Fisher, Y., Fu, I. K., Furic, J., Gartner, J., Hugon, B., Kim, J., Konigsberg, A., Korytov, A., Kropivnitskaya, T., Kypreo, J. 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A., Ofierzynski, B., Pollack, A., Pozdnyakov, M., Schmitt, S., Stoynev, M., Velasco, S., Won, L., Antonelli, D., Berry, A., Brinkerhoff, K. M., Chan, M., Hildreth, C., Jessop, D. J., Karmgard, J., Kolb, K., Lannon, W., Luo, S., Lynch, N., Marinelli, D. M., Morse, T., Pearson, M., Planer, R., Ruchti, J., Slaunwhite, N., Vall, M., Wayne, M., Wolf, B., Bylsma, L. S., Durkin, C., Hill, R., Hughe, K., Kotov, T. Y., Ling, D., Puigh, M., Rodenburg, C., Vuosalo, G., William, B. L., Winer, N., Adam, E., Berry, P., Elmer, D., Gerbaudo, V., Halyo, P., Hebda, J., Hegeman, A., Hunt, P., Jindal, D. L., Pegna, P., Lujan, D., Marlow, T., Medvedeva, M., Mooney, J., Olsen, P., Piroue, X., Quan, A., Raval, B., Safdi, H., Saka, D., Stickland, C., Tully, J. S., Werner, A., Zuranski, E., Brownson, A., Lopez, H., Mendez, J. E., R., E., Alagoz, V. E., Barne, D., Benedetti, G., Bolla, D., Bortoletto, M. D., Mattia, A., Everett, Z., Hu, M., Jone, O., Koybasi, M., Kre, A. T., Laasanen, N., Leonardo, V., Maroussov, P., Merkel, D. H., Miller, N., Neumeister, I., Shipsey, D., Silver, A., Svyatkovskiy, M. V., Marono, H. D., Yoo, J., Zablocki, Y., Zheng, S., Guragain, N., Parashar, A., Adair, C., Boulahouache, K. M., Ecklund, B. P., Padley, R., Redjimi, J., Robert, J., Zabel, B., Betchart, A., Bodek, Y. S., Chung, R., Covarelli, P. d., Barbaro, R., Demina, Y., Eshaq, T., Ferbel, A., Garcia Bellido, P., Goldenzweig, J., Han, A., Harel, D. C., Miner, D., Vishnevskiy, M., Zielinski, A., Bhatti, R., Ciesielski, L., Demortier, K., Gouliano, G., Lungu, C., Mesropian, S., Arora, A., Barker, J. P., Chou, C., Contreras Campana, E., Contreras Campana, D., Duggan, D., Ferencek, Y., Gershtein, R., Gray, E., Halkiadaki, D., Hida, A., Lath, S., Panwalkar, R., Patel, V., Rekovic, J., Roble, K., Rose, S., Salur, S., Schnetzer, C., Seitz, S., Somalwar, R., Stone, S., Thoma, M., Walker, G., Cerizza, M., Hollingsworth, S., Spanier, Z. C., Yang, A., York, R., Eusebi, W., Flanagan, J., Gilmore, T., Kamon, V., Khotilovich, R., Montalvo, I., Osipenkov, Y., Pakhotin, A., Perloff, J., Roe, A., Safonov, T., Sakuma, S., Sengupta, I., Suarez, A., Tatarinov, D., Toback, N., Akchurin, J., Damgov, C., Dragoiu, P. R., Dudero, C., Jeong, K., Kovitanggoon, S. W., Lee, T., Libeiro, Y., Roh, I., Volobouev, E., Appelt, A. G., Delannoy, C., Florez, S., Greene, A., Gurrola, W., John, P., Kurt, C., Maguire, A., Melo, M., Sharma, P., Sheldon, B., Snook, S., Tuo, J., Velkovska, M. W., Arenton, M., Balaz, S., Boutle, B., Cox, B., Franci, J., Goodell, R., Hirosky, A., Ledovskoy, C., Lin, C., Neu, J., Wood, S., Gollapinni, R., Harr, P. E., Karchin, C. K., K., P., Lamichhane, A., Sakharov, M., Anderson, D., Belknap, L., Borrello, D., Carlsmith, M., Cepeda, S., Dasu, E., Frii, L., Gray, K. S., Grogg, M., Grothe, R., Hall Wilton, M., Herndon, A., Herve, P., Klabber, J., Kluka, A., Lanaro, C., Lazaridi, J., Leonard, R., Lovele, A., Mohapatra, I., Ojalvo, F., Palmonari, G. A., Pierro, I., Ro, A., Savin, W. H., Smith, J., Swanson, and UAM. Departamento de Física Teórica
- Subjects
Muon ,Elementary particle ,7. Clean energy ,01 natural sciences ,OPAL DETECTOR ,Vector boson ,PARTICLE PHYSICS ,LARGE HADRON COLLIDER ,CMS ,High Energy Physics - Experiment ,High Energy Physics - Experiment (hep-ex) ,SINGLET ,[PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex] ,Nuclear Experiment ,Boson ,Physics ,Muons ,SUPERSYMMETRIC MODELS ,Scalar boson ,supersymmetry ,higgs ,cms ,muons ,nmssm ,lhc ,LHC ,symbols ,Higgs boson ,Physique des particules élémentaires ,GAUGE-THEORIES ,NMSSM ,PARTICLE ,Higgs mechanism ,physics ,Particle Physics - Experiment ,SUPERGRAVITY ,MASS ,EXTENSION ,BREAKING ,Higg ,Standard model ,Particle physics ,Nuclear and High Energy Physics ,FOS: Physical sciences ,Nuclear physics ,symbols.namesake ,0103 physical sciences ,ddc:530 ,010306 general physics ,Condensed Matter::Quantum Gases ,Gauge boson ,010308 nuclear & particles physics ,High Energy Physics::Phenomenology ,Física ,HEP ,Higgs ,Supersymmetry ,CMS, Higgs, LHC, Muons, NMSSM, Supersymmetry ,High Energy Physics::Experiment ,Interacting boson model - Abstract
Results are reported from a search for non-standard-model Higgs boson decays to pairs of new light bosons, each of which decays into the μ+μ- final state. The new bosons may be produced either promptly or via a decay chain. The data set corresponds to an integrated luminosity of 5.3 fb-1 of proton-proton collisions at s, 0, SCOPUS: ar.j, info:eu-repo/semantics/published
- Published
- 2013
- Full Text
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