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2 results on '"Albonico G"'

1. Pleural Melanoma Metastasis.

Author

D'Ambrosio AE, Albonico G, Enide I, Mordà O, Maisano M, and Mondello B

Subjects
Aged, 80 and over, Biopsy, Humans, Male, Melanoma diagnosis, Pleural Neoplasms diagnosis, Skin Neoplasms secondary, Tomography, X-Ray Computed, Melanoma, Cutaneous Malignant, Melanoma secondary, Pleura diagnostic imaging, Pleural Neoplasms surgery, Skin Neoplasms diagnosis, Thoracoscopy methods
Abstract

Melanomas represent 3% of all skin cancers but 65% of skin cancer deaths. Metastatic melanoma constitutes about 5% of all secondary malignancies of the lung, yet only 2% of patients with thoracic metastases have pleural effusions. We report the case of an 80-year-old patient with right-sided pleural effusion and a history of cutaneous melanoma over the left leg. Thoracoscopy revealed numerous clusters of pink and black masses arising from the visceral and parietal pleura along with the diaphragmatic surface. Biopsies confirmed the diagnosis of metastatic cutaneous melanoma., (Copyright © 2021 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.)

Published
2021
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2. Biological profile of in situ breast cancer investigated by immunohistochemical technique.

Author

Albonico G, Querzoli P, Ferretti S, Rinaldi R, and Nenci I

Subjects
Adult, Aged, Aged, 80 and over, Breast Neoplasms pathology, Carcinoma in Situ pathology, Carcinoma, Ductal, Breast pathology, Carcinoma, Lobular pathology, Cell Division, Female, Humans, Immunohistochemistry, Middle Aged, Proto-Oncogene Proteins c-bcl-2 analysis, Receptor, ErbB-2 metabolism, Receptors, Estrogen analysis, Receptors, Progesterone analysis, Tumor Suppressor Protein p53 analysis, Breast Neoplasms chemistry, Carcinoma in Situ chemistry, Carcinoma, Ductal, Breast chemistry, Carcinoma, Lobular chemistry
Abstract

In 74 in situ breast cancers an immunohistochemical study for estrogen (ER) and progesterone (PR) receptors, proliferation index (PI), and c-erbB-2, p53, and bcl-2 overexpression was performed. Cases were categorized as ductal carcinoma in situ (DCIS) comedo: 24.3% of cases; DCIS non comedo: 27% of cases; DCIS cribriform: 5.4% of cases; lobular carcinoma in situ (LCIS): 16.3% of cases; mixed carcinoma in situ: 27% of cases. Quantitation of immunohistochemical results was obtained with an image analysis computerized system (CAS 200). The cutoff values used were: 10% of positive area for ER, PR, NEU, and bcl-2; 5% of positive area for p53; 13% of PI for proliferative activity. DCIS cribriform and LCIS displayed a higher positivity for ER (92.6 and 93.8% of cases); DCIS cribriform and DCIS non comedo a higher for PR (89 and 75.3%); DCIS comedo presented the highest values for PI (65.4%), NEU (72.8%), and p53 expression (37.3%). All DCIS cribriform and DCIS non comedo and 99.6% of LCIS expressed bcl-2. The results underscore the importance of biological characterization of breast carcinoma in situ with the aim to define lesions natural history.

Published
1998
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