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6 results on '"Alex J. Rai"'

1. Absence of dense platelet granules and ceroid-laden macrophages: Investigating the diversity of clinical presentations in Hermansky-Pudlak syndrome

Author

Lanny T. DiFranza, Dong Chen, Charles C. Marboe, and Alex J. Rai

Subjects
Hermansky-Pudlak syndrome, lysosome related organelles, dense platelet granules, Pathology, RB1-214
Abstract

Hermansky-Pudlak syndrome (HPS) is an autosomal recessive genetic disorder in which the proper function of lysosome-related organelles (LROS) is impaired due to mutation in one of several well-characterized genes, including, but not limited to: HPS1, HPS3, and HPS4. Clinical manifestations include oculocutaneous albinism, nystagmus, platelet dysfunction, progressive pulmonary fibrosis, and granulomatous colitis. We present a case of a 28-year-old woman of Puerto Rican descent who required post-partum lung transplantation due to an inherited HPS1 mutation. The pathologies observed in HPS underline the mechanistic importance of LROS in a variety of tissue types and organ systems.

Published
2021
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2. Use of antibody arrays to probe exosome and extracellular vesicle mediated functional changes in cells

Author

Blake Ebert, Richard D. Carvajal, Alex J. Rai, Grazia Ambrosini, and Gary K. Schwartz

Subjects
0303 health sciences, Cell signaling, biology, Chemistry, Vesicle, Melanoma, 030303 biophysics, Extracellular vesicle, medicine.disease, Exosome, Microvesicles, Cell biology, 03 medical and health sciences, biology.protein, medicine, Liquid biopsy, Antibody
Abstract

Exosomes are small (30-200nm) membrane-bound vesicles released by all cells. They have been found in many clinical sample types, particularly those that are obtained in minimally-invasive fashion, including serum/plasma, urine, cerebrospinal and other fluids. They serve as an ideal source of biomarkers as their contents reflect the cell of origin and disease status of patients. Exosomes can serve as a "liquid biopsy," a non-invasive means to assess disease/health status in real-time. They can provide insights into disease mechanisms as they carry and transfer important signaling molecules, which may induce changes in the recipient cells. This is particularly relevant for metastatic cancers, as exosomes can prime the pre-metastatic niche. Many different approaches can be used to characterize the effects of the transfer of exosome content into the recipient cells, including global, untargeted approaches and protein-specific, targeted approaches. We describe herein our studies on the use of antibody arrays to probe for protein expression changes in hepatocytes that result from treating these cells with exosomes derived from uveal melanoma cells.

Published
2020
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4. List of contributors

Author

Khosrow Adeli, David N. Alter, Esther Babady, Lorin M. Bachmann, Shi Bai, Darci R. Block, Sean Campbell, Allison B. Chambliss, Daniel W. Chan, Alex C. Chin, Robert H. Christenson, William Clarke, Jennifer M. Colby, Margery A. Connelly, Steven W. Cotten, Jayme L. Dahlin, Sophie J. Deharvengt, Edgard Delvin, Jane Dickerson, Leslie J. Donato, Paul D’Orazio, D. Robert Dufour, Show-Hong Duh, Ashley Eckel, Shu-Ling Fan, Elizabeth L. Frank, Deanna D.H. Franke, Jonathan R. Genzen, Dina N. Greene, David S. Hage, Neil S. Harris, Matthew P.A. Henderson, Victoria Higgins, Daniel T. Holmes, Lesley A. Inker, Brian R. Jackson, Paul J. Jannetto, Hou-Sung Jung, Stephen E. Kahn, Peter A. Kavsak, Nichole Korpi-Steiner, Loralie J. Langman, Stanley T. Leung, Emile Levy, Rachael Liesman, David C. Lin, Christina M. Lockwood, Mark A. Marzinke, Stephen R. Master, Christopher R. McCudden, Gwendolyn A. McMillin, Jeffrey W. Meeusen, Stacy E.F. Melanson, Anna E. Merrill, W. Greg Miller, Robert D. Nerenz, James H. Nichols, Michelle Nieuwesteeg, Jason Y. Park, M. Laura Parnás, Khushbu Patel, J. Peter R. Pelletier, Morgan A. Pence, Lauren M. Petersen, Athena K. Petrides, Amy L. Pyle-Eilola, Alex J. Rai, Zahra Shajani-Yi, Lori J. Sokoll, Joely A. Straseski, Stefani N. Thomas, Katie L. Thoren, John Toffaletti, Steven M. Truscott, Gregory J. Tsongalis, Alisha D. Ware, Joesph R. Wiencek, Maria Alice V. Willrich, William E. Winter, Alison Woodworth, and Alan H.B. Wu

Published
2020
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6. Contributors

Author

Thomas M. Annesley, Fred S. Apple, Edward R. Ashwood, Michael N. Badminton, Renze Bais, James C. Barton, Howard J. Baum, Lindsay A.L. Bazydlo, Laura Bechtel, Roger L. Bertholf, Aaron D. Bossler, Patrick M.M. Bossuyt, James C. Boyd, David E. Bruns, Carl A. Burtis, Angela M. Caliendo, Daniel W. Chan, Rossa W.K. Chiu, Allan C. Deacon, Michael P. Delaney, Paul D’Orazio, Basil T. Doumas, D. Robert Dufour, John H. Eckfeldt, Graeme Eisenhofer, George H. Elder, Kojo S.J. Elenitoba-Johnson, Jens Peter Goetze, Bruce A. Goldberger, David G. Grenache, Ann M. Gronowski, Amy R. Groszbach, Doris M. Haverstick, Charles D. Hawker, Russell A. Higgins, Trefor Higgins, Peter G. Hill, Christopher P. Holstege, Joshua L. Hood, Gary L. Horowitz, Glen L. Hortin, T. Scott Isbell, Allan S. Jaffe, Ishwarlal Jialal, Emily S. Jungheim, Raymond E. Karcher, Malek Kaumon, Steve Kitchen, George G. Klee, Michael Kleerekoper, Larry J. Kricka, Noriko Kusukawa, Edmund J. Lamb, Geralyn Lambert-Messerlian, James P. Landers, Loralie Langman, Vicky A. LeGrys, Kristian Linnet, Y.M. Dennis Lo, Stanley F. Lo, Nicola Longo, Gwendolyn A. McMillin, Mark E. Meyerhoff, Thomas P. Moyer, John D. Olson, Mauro Panteghini, Jason Y. Park, Marzia Pasquali, Christopher P. Price, Alex J. Rai, Alan T. Remaley, Nader Rifai, Juha Risteli, Leila Risteli, Norman B. Roberts, William L. Roberts, Alan L. Rockwood, Thomas G. Rosano, David B. Sacks, Desmond Schatz, Mitchell G. Scott, Alan Shenkin, Nicholas E. Sherman, Christine L.H. Snozek, Lori J. Sokoll, Andrew St. John, Wouter W. van Solinge, Richard van Wijk, Mary Lee Vance, Cindy L. Vnencak-Jones, G. Russell Warnick, Victor W. Weedn, James O. Westgard, Sharon D. Whatley, Ronald J. Whitley, Thomas M. Williams, William E. Winter, Carl T. Wittwer, and Donald S. Young

Published
2012
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