1. Urinary NT-proBNP compared head-to-head to plasmatic NT-proBNP in a real life collective with an ICD
- Author
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Benedikt Seither, Alexander Schober, Raphael Allgaier, Christine Meindl, Michael Paulus, Ute Hubauer, Andreas Schober, Ekrem Ücer, Sabine Fredersdorf, Petra Lehn, Andreas Keyser, Andreas Luchner, Lars Maier, Stefan Wallner, and Carsten Jungbauer
- Subjects
Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Aims: Plasma NT-proBNP is an established marker of heart failure. Previous studies suggested urinary NT-proBNP has potential as marker of chronic heart failure as well. The objective of this study was to compare urinary NT-proBNP to plasma NT-proBNP in a real-life collective of patients with an ICD, especially regarding ICD-therapies. Methods & results: NT-proBNP was assessed in plasma and fresh spot urine (the latter related to urinary creatinine) from 322 patients of our ICD outpatient clinic. 54 healthy individuals served as a control group. Follow-up regarding mortality and ICD therapies was performed after 32 months (IQR 5–35 months). Plasma and urinary NT-proBNP was positively correlated (r = 0.89, p Youden-Index showed significantly higher event rates for appropriate ICD-shock therapies (p
- Published
- 2024
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