1. Presynaptic Receptors Modulating Transmitter Release: Physiological and Pharmacological Aspects
- Author
-
Guido Maura, Giambattista Bonanno, Paolo Paudice, Mario Marchi, Anna Pittaluga, Mario Pende, Anita Gemignani, Maurizio Raiteri, and C. Drago
- Subjects
Kainate receptor ,Biology ,Pharmacology ,chemistry.chemical_compound ,medicine.anatomical_structure ,chemistry ,Postsynaptic potential ,medicine ,Axon ,Neurotransmitter ,Receptor ,Long-term depression ,Postsynaptic density ,Neuroscience ,Function (biology) - Abstract
The mammalian brain contains a myriad of receptors localized on neuronal axon terminals (presynaptic receptors) the function of which is to modulate neurotransmitter release. Similarly to postsynaptic receptors, presynaptic receptors exist as pharmacologically distinct types and subtypes. Inasmuch as modulation of release is the functional response that follows their activation, transmitter release represents an excellent model to investigate receptors in general as well as to test potentially novel and more selective drugs. Types and subtypes of presynaptic receptors regulating the release of various transmitters will be described and their potential involvement in different pathophysiological conditions will be discussed.
- Published
- 1992
- Full Text
- View/download PDF