1. Association between prenatal exposure to perfluorinated compounds and symptoms of infections at age 1–4 years among 359 children in the Odense Child Cohort
- Author
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Henriette Boye Kyhl, Tina Kold Jensen, Flemming Nielsen, Louise Dalsager, Steffen Husby, Philippe Grandjean, Arne Høst, and Nikolas Christensen
- Subjects
Male ,0301 basic medicine ,Pediatrics ,Denmark ,010501 environmental sciences ,Logistic regression ,01 natural sciences ,Perfluorononanoic acid ,chemistry.chemical_compound ,Pregnancy ,Prenatal exposure ,Epidemiology ,Prevalence ,Immunotoxicity ,Prospective Studies ,Prospective cohort study ,lcsh:Environmental sciences ,General Environmental Science ,lcsh:GE1-350 ,Fluorocarbons ,Parity ,Alkanesulfonic Acids ,Child, Preschool ,Prenatal Exposure Delayed Effects ,Cohort ,Gestation ,Perfluorooctanoic acid ,Female ,Caprylates ,Cohort study ,Adult ,medicine.medical_specialty ,Fever ,Childhood infections ,Infections ,Young Adult ,03 medical and health sciences ,medicine ,Humans ,0105 earth and related environmental sciences ,business.industry ,Infant ,Environmental Exposure ,Perfluorinated compounds ,030104 developmental biology ,chemistry ,Sulfonic Acids ,business ,Decanoic Acids - Abstract
Introduction: Perfluorinated alkylated substances (PFAS) are persistent industrial chemicals that have resulted in global environmental exposures. Previous epidemiological studies have reported possible effects on the immune system after developmental PFAS exposure, but the possible impact on childhood infectious disease is unclear. Objectives: To investigate the association between prenatal exposure to PFAS and symptoms of infections at age 1–4 years. Methods: The Odense Child Cohort is an on-going prospective study on children's health, where serum concentrations of perfluorooctane sulfonic acid (PFOS), perfluorooctanoic acid (PFOA), perfluorohexane sulfonic acid (PFHxS), perfluorodecanoic acid (PFDA) and perfluorononanoic acid (PFNA) were measured in 649 pregnant women before gestational week 16. Of these women, 359 reported on symptoms of infection in their child every two weeks for a one-year period. The association between prenatal exposure to PFAS and the symptoms was estimated using a logistic regression model and a negative binomial regression model. For the latter, the outcome was reported as an incidence rate-ratio (IRR), and all models were adjusted for maternal age, educational level, parity and child age. Results: On average, the children experienced symptoms of infection 23% of the time during one year. PFOS exposure in the high tertile compared to the low tertile was associated with a statistically significant increased proportion of days with fever (IRR: 1.65 (95% CI: 1.24, 2.18), P-trend
- Published
- 2016
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