16 results on '"BACKER, LORRAINE C."'
Search Results
2. Contributors
- Author
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Aasly, Kurt, primary, Abós-Herràndiz, Rafael, additional, Ainsworth, Gillian B., additional, Alaba, Maria Retchie, additional, Alarcon, Rowell, additional, Alcantara-Creencia, Lota, additional, Allué, Rosario, additional, Almohammadi, Doha Saad A., additional, Aludia, Geofrey M., additional, Aludia, Phoebejean H., additional, Ang, Li Wei, additional, Antunes, Edith M., additional, Ariffin, Wan Nur Syazana Wan Mohamad, additional, Aruta, John Jamir Benzon R., additional, Backe, Karen Herrero, additional, Backer, Lorraine C., additional, Badaruddin, Hishamuddin, additional, Belgrano, Andrea, additional, Benkendorff, Kirsten, additional, Bennett, Baylin, additional, Bennett, Nathan, additional, Berdalet, Elisa, additional, Beukes, Denzil R., additional, Bienfait, André Marcel, additional, Blackford, Krysten, additional, Botta, Robert D., additional, Bouley, Timothy A., additional, Bridge, Nicola L., additional, Britton, Easkey, additional, Broad, Kenneth, additional, Brooks, Bryan W., additional, Buchan, Pamela M., additional, Callwood, Karlisa, additional, Canonico, Gabrielle, additional, Carić, Hrvoje, additional, Carlarne, Cinnamon Piñon, additional, Caro-Diaz, Eduardo J.E., additional, Carreño, Arnau, additional, Carvalho, Matthew, additional, Champion, Curtis, additional, Chassignet, Eric P., additional, Chen, Celia, additional, Chinain, Mireille, additional, Coffey, Kara, additional, Coleman, Melinda A, additional, Colom, Imma, additional, Court, Christa, additional, Cowan, Emily, additional, Crummy, Aoife, additional, Cui, Lin, additional, Cunningham, Emily G., additional, Cunsolo, Ashlee, additional, Cutter, Jeffery, additional, Da Costa, Paulo Martins, additional, Dankel, Dorothy J., additional, Darius, H. Taiana, additional, Davies, Adesina David, additional, Depledge, Michael H., additional, DeTomaso, Anthony W., additional, Devine, Dympna, additional, Dumbili, E., additional, Dupont, Sam, additional, Ellefmo, Steinar Løve, additional, Elmore II, Brockway, additional, Enciso, Olga, additional, Estenik, John, additional, Fabro, Keith Anthony, additional, Falkenberg, Laura J, additional, Fielding, Russell, additional, Fleming, Lora E., additional, Foltz, Kathleen, additional, Fontdecaba, Eva, additional, Forbes, Vivian Louis, additional, Gajardo, Lea Janine A., additional, Gascons, Ramon, additional, Gaspers, Anne, additional, Gatti, Clémence M.I., additional, Gedoria, Gerlie, additional, Gerwick, William H., additional, Gin, Karina Yew-Hoong, additional, Giner, Francesc, additional, Gleason, Michelle E., additional, Goh, Hong Ching, additional, Goh, Shin Giek, additional, Gómez, Sílvia, additional, Gonzales, Benjamin J., additional, Gordon, Vanessa, additional, Gribble, Matthew O., additional, Ha, Nguyen Thu, additional, Hamdoun, Amro, additional, Hamzah, B.A., additional, Hansen, Dorte, additional, Hara, Jenevieve, additional, Hargraves, Joshua, additional, Harper, Sherilee, additional, Henderson, Lesley, additional, Hien, Vu Thuc, additional, Higley, Kathryn A., additional, Hixson, Richard, additional, Hollenbeck, Julie, additional, Izquierdo, Angel, additional, Jacquet, Jennifer, additional, Jahateh, Betty, additional, Jalover-Par, Cherry Lyn, additional, James, Rathunam Arthur, additional, Johari, Sofia, additional, Jong, Mui Choo, additional, Joyce, Patrick WS, additional, Jungwiwattanaporn, Megan, additional, Justine, Eva Vivian, additional, Kawabe, Larissa A., additional, Keast, Jake, additional, Kelsey, R. Heath, additional, Kieszak, Stephanie, additional, Kirkpatrick, Barbara, additional, Kjørholt, Anne Trine, additional, Koeneke, Roberto, additional, Koh, Han Fang, additional, Kuit, Sui Hyang, additional, Kustka, Stephen, additional, Lavery, Amy, additional, Lee, Kwai Han, additional, Li, Wenxuan, additional, Lin, Raymond Tzer Pin, additional, Lin, Yijun, additional, Lloret, Josep, additional, Lloveras, Montse, additional, Lohmann, Rainer, additional, Lopes, Natalia Pirani Ghilardi, additional, Macdonald, Catherine, additional, Machalaba, Catherine, additional, Madarcos, John Roderick V., additional, Madarcos, Karen Gabalez, additional, Maharja, Carya, additional, Manfredi, Juan Luis, additional, Marathe, Nachiket P., additional, Marshall, Jamie, additional, Mas, Lluïsa, additional, Mason, Robert, additional, Mathis, Jeremy, additional, Maycock, Bruce, additional, McKinney, Raiana, additional, Middleton, Jacqueline, additional, Mills, David Jonathan, additional, Mindan, Montse, additional, Minuto, Stefania, additional, Moore, Amelia, additional, Morris, George, additional, Mugau, Sharon Mansarah, additional, Muir, Derek, additional, Muthukumar, Krishnan, additional, Narchi, Nemer E., additional, Newmyer, Jillian, additional, Newton, John N., additional, Ng, Charmaine, additional, Nimje, Priyank S., additional, Nordmann, Patrice, additional, O’Halloran, Chris, additional, Oftebro, Thea Lurås, additional, Olugbemi, Peter Wusu, additional, OOi, Peng Lim, additional, Owoade, Folasade Mary, additional, Pahl, Sabine, additional, Patil, Bodhi, additional, Pita, Pablo, additional, Plana, Joan, additional, Poirel, Laurent, additional, Poo, Kelly, additional, Porter, Dwayne E., additional, Portsmouth, Linda, additional, Pouso, Sarai, additional, Praet, Estelle, additional, Praptiwi, Radisti A., additional, Pratt, Dawn O., additional, Rabbottini, Lauren, additional, Radisic, Vera, additional, Ramage, Dan W., additional, Raps, Hervé, additional, Reich, Andrew, additional, Richter, Isabel, additional, Roberts, Virginia A., additional, Roué, Mélanie, additional, Saine, Dawda Foday, additional, Sajorne, Recca E., additional, San, Joan, additional, Sandifer, Paul A., additional, Scanes, Elliot, additional, Schnall, Amy H., additional, Schofield, John, additional, Schwacke, Lori H., additional, Scott, Geoffrey I., additional, Shalders, Tanika C, additional, Simões, Roméo Rocha, additional, Solo-Gabriele, Helena, additional, Songco, Angelique M., additional, Sowman, Georgie J., additional, Stephan, Wendy Blair, additional, Stricker, Adam, additional, Stumpf, Richard P., additional, Sumaila, Ussif Rashid, additional, Tan, Lik Tong, additional, Tan, Shermin, additional, Taufek, Norhidayah Mohd, additional, Teicher, Sam, additional, Tester, Patricia A., additional, Thao, Le Ngoc, additional, Then, Amy Yee-Hui, additional, Thiel, Martin, additional, Tong, Xuneng, additional, Tow, Charlene, additional, Trainer, Vera, additional, Turra, Alexander, additional, Uyarra, María C., additional, Vendrell, Cristina, additional, Vert, Cristina, additional, Vigar, Marissa, additional, Vignesh, Sivanandham, additional, Villasante, Sebastian, additional, Voronkova, Anastasia, additional, Wester, Julia, additional, Wowk, Katya, additional, Wozniak, Esther, additional, Wulandari, Prawesti, additional, Wyles, Kayleigh J., additional, Yu, Pei Lin, additional, and Zhang, Yiwen, additional
- Published
- 2023
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3. Contributors
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Alkaitis, Matthew S., primary, Backer, Lorraine C., additional, Blackmore, Carina, additional, Ceilley, Roger I., additional, Conti, Lisa A., additional, Currier, Russell W., additional, DuVernoy, Tracy, additional, Fleming, Lora E., additional, Hollender, Elena, additional, Johnson, Rebecca A., additional, Kahn, Laura H., additional, Kaplan, Bruce, additional, Mainzer, Hugh M., additional, Mitchell, Clifford S., additional, Mobo, Ben Hur P., additional, Monath, Thomas P., additional, Odofin, Lynda U., additional, Rabinowitz, Natasha, additional, Rabinowitz, Peter M., additional, Reinero, Carol Norris, additional, Sparer, Judy, additional, Taiwo, Oyebode A., additional, and Zaias, Julia, additional
- Published
- 2010
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4. Environmental contaminants in coastal populations: Comparisons with the National Health and Nutrition Examination Survey (NHANES) and resident dolphins.
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Backer LC, Bolton B, Litz JA, Trevillian J, Kieszak S, and Kucklick J
- Subjects
- Animals, Environmental Monitoring, Humans, Nutrition Surveys, Bottle-Nosed Dolphin, Dolphins, Water Pollutants, Chemical analysis
- Abstract
Background: People living in coastal communities are at risk for exposure to environmental hazards, including legacy chemicals. We can use databases such as NHANES to assess whether contaminants in coastal communities are present in higher levels than in the United States overall. We can use information from studies of local animal populations to assess which of these contaminants could have been transferred to people from their shared environment., Objective: Our objectives were to examine the POP profiles in human populations in areas where there are published POP profiles in resident dolphins and to compare our results with data from NHANES and the dolphin studies., Methods: We identified three areas where POPs have been analyzed in local resident dolphin populations (total N =73). We identified human communities in the same areas, and asked 27 eligible adults to read and sign a consent form, complete a questionnaire about demographics and seafood consumption, provide nine 10-mL blood samples, and provide one sample of seafood ( N = 33). Blood and seafood were analyzed for a suite of POPs similar to those analyzed in published dolphin population studies. We compared the results from human blood analyses with NHANES and with data from the published reports of dolphin studies., Results: Levels and proportions of specific POPs found in people and animals reflect POPs found in the local environment. Compared with the nationally representative data reported in NHANES, the levels of many POPs found in high levels in dolphins were also higher in the corresponding human communities., Conclusions: Contaminants measured in marine animals, such as dolphins, can be used to identify the types and relative levels of environmental contaminants expected to occur in people sharing the same environment. Likewise, contaminants measured in coastal human populations can provide insight into which contaminants may be found in nearby animal populations., Competing Interests: Declaration of competing interest The authors have no conflicts of interest to disclose.
- Published
- 2019
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5. Assessing arsenic exposure in households using bottled water or point-of-use treatment systems to mitigate well water contamination.
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Smith AE, Lincoln RA, Paulu C, Simones TL, Caldwell KL, Jones RL, and Backer LC
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- Environmental Monitoring, Family Characteristics, Humans, Maine, Water Purification, Arsenic analysis, Drinking Water chemistry, Environmental Exposure statistics & numerical data, Water Pollutants, Chemical analysis, Water Wells
- Abstract
There is little published literature on the efficacy of strategies to reduce exposure to residential well water arsenic. The objectives of our study were to: 1) determine if water arsenic remained a significant exposure source in households using bottled water or point-of-use treatment systems; and 2) evaluate the major sources and routes of any remaining arsenic exposure. We conducted a cross-sectional study of 167 households in Maine using one of these two strategies to prevent exposure to arsenic. Most households included one adult and at least one child. Untreated well water arsenic concentrations ranged from <10 μg/L to 640 μg/L. Urine samples, water samples, daily diet and bathing diaries, and household dietary and water use habit surveys were collected. Generalized estimating equations were used to model the relationship between urinary arsenic and untreated well water arsenic concentration, while accounting for documented consumption of untreated water and dietary sources. If mitigation strategies were fully effective, there should be no relationship between urinary arsenic and well water arsenic. To the contrary, we found that untreated arsenic water concentration remained a significant (p ≤ 0.001) predictor of urinary arsenic levels. When untreated water arsenic concentrations were <40 μg/L, untreated water arsenic was no longer a significant predictor of urinary arsenic. Time spent bathing (alone or in combination with water arsenic concentration) was not associated with urinary arsenic. A predictive analysis of the average study participant suggested that when untreated water arsenic ranged from 100 to 500 μg/L, elimination of any untreated water use would result in an 8%-32% reduction in urinary arsenic for young children, and a 14%-59% reduction for adults. These results demonstrate the importance of complying with a point-of-use or bottled water exposure reduction strategy. However, there remained unexplained, water-related routes of exposure., (Copyright © 2015 Elsevier B.V. All rights reserved.)
- Published
- 2016
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6. Current approaches to cyanotoxin risk assessment and risk management around the globe.
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Ibelings BW, Backer LC, Kardinaal WE, and Chorus I
- Abstract
Toxic cyanobacteria became more widely recognized as a potential health hazard in the 1990s, and in 1998 the World Health Organization (WHO) first published a provisional Guideline Value of 1 μg L
-1 for microcystin-LR in drinking-water. In this publication we compare risk assessment and risk management of toxic cyanobacteria in 17 countries across all five continents. We focus on the three main (oral) exposure vehicles to cyanotoxins: drinking-water, water related recreational and freshwater seafood. Most countries have implemented the provisional WHO Guideline Value, some as legally binding standard, to ensure the distribution of safe drinking-water with respect to microcystins. Regulation, however, also needs to address the possible presence of a wide range of other cyanotoxins and bioactive compounds, for which no guideline values can be derived due to insufficient toxicological data. The presence of microcystins (commonly expressed as microcystin-LR equivalents) may be used as proxy for overall guidance on risk management, but this simplification may miss certain risks, for instance from dissolved fractions of cylindrospermopsin and cyanobacterial neurotoxins. An alternative approach, often taken for risk assessment and management in recreational waters, is to regulate cyanobacterial presence - as cell numbers or biomass - rather than individual toxins. Here, many countries have implemented a two or three tier alert level system with incremental severity. These systems define the levels where responses are switched from Surveillance to Alert and finally to Action Mode and they specify the short-term actions that follow. Surface bloom formation is commonly judged to be a significant risk because of the elevated concentration of microcystins in a scum. Countries have based their derivations of legally binding standards, guideline values, maximally allowed concentrations (or limits named otherwise) on very similar scientific methodology, but underlying assumptions such as bloom duration, average body size and the amount of water consumed while swimming vary according to local circumstances. Furthermore, for toxins with incomplete toxicological data elements of expert judgment become more relevant and this also leads to a larger degree of variation between countries' thresholds triggering certain actions. Cyanobacterial blooms and their cyanotoxin content are a highly variable phenomenon, largely depending on local conditions, and likely concentrations can be assessed and managed best if the specific conditions of the locality are known and their impact on bloom occurrence are understood. Risk Management Frameworks, such as for example the Water Safety Plan concept of the WHO and the 'bathing water profile' of the European Union are suggested to be effective approaches for preventing human exposure by managing toxic cyanobacteria from catchment to consumer for drinking water and at recreational sites.- Published
- 2015
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7. Florida Red Tide Toxins (Brevetoxins) and Longitudinal Respiratory Effects in Asthmatics.
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Bean JA, Fleming LE, Kirkpatrick B, Backer LC, Nierenberg K, Reich A, Cheng YS, Wanner A, Benson J, Naar J, Pierce R, Abraham WM, Kirkpatrick G, Hollenbeck J, Zaias J, Mendes E, and Baden DG
- Abstract
Having demonstrated significant and persistent adverse changes in pulmonary function for asthmatics after 1 hour exposure to brevetoxins in Florida red tide (Karenia brevis bloom) aerosols, we assessed the possible longer term health effects in asthmatics from intermittent environmental exposure to brevetoxins over 7 years. 125 asthmatic subjects were assessed for their pulmonary function and reported symptoms before and after 1 hour of environmental exposure to Florida red tide aerosols for upto 11 studies over seven years. As a group, the asthmatics came to the studies with normal standardized percent predicted pulmonary function values. The 38 asthmatics who participated in only one exposure study were more reactive compared to the 36 asthmatics who participated in ≥4 exposure studies. The 36 asthmatics participating in ≥4 exposure studies demonstrated no significant change in their standardized percent predicted pre-exposure pulmonary function over the 7 years of the study. These results indicate that stable asthmatics living in areas with intermittent Florida red tides do not exhibit chronic respiratory effects from intermittent environmental exposure to aerosolized brevetoxins over a 7 year period.
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- 2011
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8. Frontiers in Outreach and Education: The Florida Red Tide Experience.
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Nierenberg K, Hollenbeck J, Fleming LE, Stephan W, Reich A, Backer LC, Currier R, and Kirkpatrick B
- Abstract
To enhance information sharing and garner increased support from the public for scientific research, funding agencies now typically require that research groups receiving support convey their work to stakeholders. The National Institute of Environmental Health Sciences-(NIEHS) funded Aerosolized Florida Red Tide P01 research group (Florida Red Tide Research Group) has employed a variety of outreach strategies to meet this requirement. Messages developed from this project began a decade ago and have evolved from basic print material (fliers and posters) to an interactive website, to the use of video and social networking technologies, such as Facebook and Twitter. The group was able to track dissemination of these information products; however, evaluation of their effectiveness presented much larger challenges. The primary lesson learned by the Florida Red Tide Research Group is that the best ways to reach specific stakeholders is to develop unique products or services to address specific stakeholders needs, such as the Beach Conditions Reporting System. Based on the experience of the Group, the most productive messaging products result when scientific community engages potential stakeholders and outreach experts during the very initial phases of a project.
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- 2011
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9. Review of Florida Red Tide and Human Health Effects.
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Fleming LE, Kirkpatrick B, Backer LC, Walsh CJ, Nierenberg K, Clark J, Reich A, Hollenbeck J, Benson J, Cheng YS, Naar J, Pierce R, Bourdelais AJ, Abraham WM, Kirkpatrick G, Zaias J, Wanner A, Mendes E, Shalat S, Hoagland P, Stephan W, Bean J, Watkins S, Clarke T, Byrne M, and Baden DG
- Abstract
This paper reviews the literature describing research performed over the past decade on the known and possible exposures and human health effects associated with Florida red tides. These harmful algal blooms are caused by the dinoflagellate, Karenia brevis, and similar organisms, all of which produce a suite of natural toxins known as brevetoxins. Florida red tide research has benefited from a consistently funded, long term research program, that has allowed an interdisciplinary team of researchers to focus their attention on this specific environmental issue-one that is critically important to Gulf of Mexico and other coastal communities. This long-term interdisciplinary approach has allowed the team to engage the local community, identify measures to protect public health, take emerging technologies into the field, forge advances in natural products chemistry, and develop a valuable pharmaceutical product. The Review includes a brief discussion of the Florida red tide organisms and their toxins, and then focuses on the effects of these toxins on animals and humans, including how these effects predict what we might expect to see in exposed people.
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- 2011
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10. Aerosolized Red Tide Toxins (Brevetoxins) and Asthma: Continued health effects after 1 hour beach exposure.
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Kirkpatrick B, Fleming LE, Bean JA, Nierenberg K, Backer LC, Cheng YS, Pierce R, Reich A, Naar J, Wanner A, Abraham WM, Zhou Y, Hollenbeck J, and Baden DG
- Abstract
Blooms of the toxic dinoflagellate, Karenia brevis, produce potent neurotoxins in marine aerosols. Recent studies have demonstrated acute changes in both symptoms and pulmonary function in asthmatics after only 1 hour of beach exposure to these aerosols. This study investigated if there were latent and/or sustained effects in asthmatics in the days following the initial beach exposure during periods with and without an active Florida red tide.Symptom data and spirometry data were collected before and after 1 hour of beach exposure. Subjects kept daily symptom diaries and measured their peak flow each morning for 5 days following beach exposure. During non-exposure periods, there were no significant changes in symptoms or pulmonary function either acutely or over 5 days of follow-up. After the beach exposure during an active Florida red tide, subjects had elevated mean symptoms which did not return to the pre-exposure baseline for at least 4 days. The peak flow measurements decreased after the initial beach exposure, decreased further within 24 hours, and continued to be suppressed even after 5 days. Asthmatics may continue to have increased symptoms and delayed respiratory function suppression for several days after 1 hour of exposure to the Florida red tide toxin aerosols.
- Published
- 2011
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11. Florida Red Tide Perception: Residents versus Tourists.
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Nierenberg K, Byrne M, Fleming LE, Stephan W, Reich A, Backer LC, Tanga E, Dalpra DR, and Kirkpatrick B
- Abstract
The west coast of Florida has annual blooms of the toxin-producing dinoflagellate, Karenia brevis with Sarasota, FL considered the epicenter for these blooms. Numerous outreach materials, including Frequently Asked Question (FAQ) cards, exhibits for local museums and aquaria, public beach signs, and numerous websites have been developed to disseminate information to the public about this natural hazard. In addition, during intense onshore blooms, a great deal of media attention, primarily via newspaper (print and web) and television, is focused on red tide. However to date, the only measure of effectiveness of these outreach methods has been counts of the number of people exposed to the information, e.g., visits to a website or number of FAQ cards distributed. No formal assessment has been conducted to determine if these materials meet their goal of informing the public about Florida red tide. Also, although local residents have the opinion that they are very knowledgeable about Florida red tide, this has not been verified empirically. This study addressed these issues by creating and administering an evaluation tool for the assessment of public knowledge about Florida red tide. A focus group of Florida red tide outreach developers assisted in the creation of the evaluation tool. The location of the evaluation was the west coast of Florida, in Sarasota County. The objective was to assess the knowledge of the general public about Florida red tide. This assessment identified gaps in public knowledge regarding Florida red tides and also identified what information sources people want to use to obtain information on Florida red tide. The results from this study can be used to develop more effective outreach materials on Florida red tide.
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- 2010
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12. Inland Transport of Aerosolized Florida Red Tide Toxins.
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Kirkpatrick B, Pierce R, Cheng YS, Henry MS, Blum P, Osborn S, Nierenberg K, Pederson BA, Fleming LE, Reich A, Naar J, Kirkpatrick G, Backer LC, and Baden D
- Abstract
Florida red tides, an annual event off the west coast of Florida, are caused by the toxic dinoflagellate, Karenia brevis. K. brevis produces a suite of potent neurotoxins, brevetoxins, which kill fish, sea birds, and marine mammals, as well as sickening humans who consume contaminated shellfish. These toxins become part of the marine aerosol, and can also be inhaled by humans and other animals. Recent studies have demonstrated a significant increase in symptoms and decrease lung function in asthmatics after only one hour of beach exposure during an onshore Florida red tide bloom.This study constructed a transect line placing high volume air samplers to measure brevetoxins at sites beginning at the beach, moving approximately 6.4 km inland. One non-exposure and 2 exposure studies, each of 5 days duration, were conducted. No toxins were measured in the air during the non-exposure period. During the 2 exposure periods, the amount of brevetoxins varied considerably by site and by date. Nevertheless, brevetoxins were measured at least 4.2 kilometers from the beach and/or 1.6 km from the coastal shoreline. Therefore, populations sensitive to brevetoxins (such as asthmatics) need to know that leaving the beach may not discontinue their environmental exposure to brevetoxin aerosols.
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- 2010
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13. Microbial concentrations on fresh produce are affected by postharvest processing, importation, and season.
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Ailes EC, Leon JS, Jaykus LA, Johnston LM, Clayton HA, Blanding S, Kleinbaum DG, Backer LC, and Moe CL
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- Bacteria isolation & purification, Colony Count, Microbial, Commerce, Consumer Product Safety, Disease Outbreaks prevention & control, Enterobacteriaceae growth & development, Enterobacteriaceae isolation & purification, Escherichia coli growth & development, Escherichia coli isolation & purification, Food Contamination prevention & control, Food Handling standards, Food Microbiology, Food Packaging methods, Food Packaging standards, Logistic Models, Predictive Value of Tests, Seasons, United States, Vegetables standards, Bacteria growth & development, Food Contamination analysis, Food Handling methods, Food Preservation methods, Vegetables microbiology
- Abstract
In the United States, the proportion of foodborne illness outbreaks associated with consumption of contaminated domestic and imported fresh fruits and vegetables (produce) has increased over the past several decades. To address this public health concern, the goal of this work was to identify and quantify factors associated with microbial contamination of produce in pre- and postharvest phases of the farm-to-fork continuum. From 2000 to 2003, we collected 923 samples of 14 types of produce (grown in the southern United States or in the northern border states of Mexico) from 15 farms and eight packing sheds located in the southern United States. To assess microbial quality, samples were enumerated for Escherichia coli, total aerobic bacteria, total coliforms, and total Enterococcus. Most produce types had significantly higher microbial concentrations when sampled at the packing shed than when sampled at the farm. In addition, we observed seasonal differences in the microbial concentrations on samples grown in the United States, with higher mean indicator concentrations detected in the fall (September, October, and November). We developed a predictive, multivariate logistic regression model to identify and quantify factors that were associated with detectable concentrations of E. coli contamination on produce. These factors included produce type (specifically, cabbage or cantaloupe), season of collection (harvested in the fall), and packing step (bin, box, conveyor belt, or turntable). These results can be used to identify specific mechanisms of produce contamination and propose interventions that may decrease the likelihood of produce-associated illness.
- Published
- 2008
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14. Florida red tide and human health: a pilot beach conditions reporting system to minimize human exposure.
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Kirkpatrick B, Currier R, Nierenberg K, Reich A, Backer LC, Stumpf R, Fleming L, and Kirkpatrick G
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- Animals, Cities, Florida, Geography, Humans, Seawater, Swimming, Time Factors, Weather, Wind, Asthma etiology, Dinoflagellida pathogenicity, Environment, Inhalation Exposure, Marine Toxins toxicity, Oxocins toxicity, Public Health, Recreation
- Abstract
With over 50% of the US population living in coastal counties, the ocean and coastal environments have substantial impacts on coastal communities. While many of the impacts are positive, such as tourism and recreation opportunities, there are also negative impacts, such as exposure to harmful algal blooms (HABs) and water borne pathogens. Recent advances in environmental monitoring and weather prediction may allow us to forecast these potential adverse effects and thus mitigate the negative impact from coastal environmental threats. One example of the need to mitigate adverse environmental impacts occurs on Florida's west coast, which experiences annual blooms, or periods of exuberant growth, of the toxic dinoflagellate, Karenia brevis. K. brevis produces a suite of potent neurotoxins called brevetoxins. Wind and wave action can break up the cells, releasing toxin that can then become part of the marine aerosol or sea spray. Brevetoxins in the aerosol cause respiratory irritation in people who inhale it. In addition, asthmatics who inhale the toxins report increase upper and lower airway symptoms and experience measurable changes in pulmonary function. Real-time reporting of the presence or absence of these toxic aerosols will allow asthmatics and local coastal residents to make informed decisions about their personal exposures, thus adding to their quality of life. A system to protect public health that combines information collected by an Integrated Ocean Observing System (IOOS) has been designed and implemented in Sarasota and Manatee Counties, Florida. This system is based on real-time reports from lifeguards at the eight public beaches. The lifeguards provide periodic subjective reports of the amount of dead fish on the beach, apparent level of respiratory irritation among beach-goers, water color, wind direction, surf condition, and the beach warning flag they are flying. A key component in the design of the observing system was an easy reporting pathway for the lifeguards to minimize the amount of time away from their primary duties. Specifically, we provided a Personal Digital Assistant for each of the eight beaches. The portable unit allows the lifeguards to report from their guard tower. The data are transferred via wireless Internet to a website hosted on the Mote Marine Laboratory Sarasota Operations of the Coastal Ocean Observation Laboratories (SO COOL) server. The system has proven to be robust and well received by the public. The system has reported variability from beach to beach and has provided vital information to users to minimize their exposure to toxic marine aerosols.
- Published
- 2008
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15. Aerosolized red-tide toxins (brevetoxins) and asthma.
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Fleming LE, Kirkpatrick B, Backer LC, Bean JA, Wanner A, Reich A, Zaias J, Cheng YS, Pierce R, Naar J, Abraham WM, and Baden DG
- Subjects
- Adolescent, Adult, Aerosols, Aged, Animals, Child, Chromatography, High Pressure Liquid, Environmental Monitoring, Enzyme-Linked Immunosorbent Assay, Female, Florida, Humans, Inhalation Exposure, Male, Mass Spectrometry, Middle Aged, Respiratory Function Tests, Surveys and Questionnaires, Asthma etiology, Dinoflagellida pathogenicity, Marine Toxins toxicity, Oxocins toxicity
- Abstract
Background: With the increasing incidence of asthma, there is increasing concern over environmental exposures that may trigger asthma exacerbations. Blooms of the marine microalgae, Karenia brevis, cause red tides (or harmful algal blooms) annually throughout the Gulf of Mexico. K brevis produces highly potent natural polyether toxins, called brevetoxins, which are sodium channel blockers, and possibly histamine activators. In experimental animals, brevetoxins cause significant bronchoconstriction. In humans, a significant increase in self-reported respiratory symptoms has been described after recreational and occupational exposures to Florida red-tide aerosols, particularly among individuals with asthma., Methods: Before and after 1 h spent on beaches with and without an active K brevis red-tide exposure, 97 persons >or= 12 years of age with physician-diagnosed asthma were evaluated by questionnaire and spirometry. Concomitant environmental monitoring, water and air sampling, and personal monitoring for brevetoxins were performed., Results: Participants were significantly more likely to report respiratory symptoms after K brevis red-tide aerosol exposure than before exposure. Participants demonstrated small, but statistically significant, decreases in FEV(1), midexpiratory phase of forced expiratory flow, and peak expiratory flow after exposure, particularly among those participants regularly using asthma medications. No significant differences were detected when there was no Florida red tide (ie, during nonexposure periods)., Conclusions: This study demonstrated objectively measurable adverse changes in lung function from exposure to aerosolized Florida red-tide toxins in asthmatic subjects, particularly among those requiring regular therapy with asthma medications. Future studies will assess these susceptible subpopulations in more depth, as well as the possible long-term effects of these toxins.
- Published
- 2007
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16. Environmental exposures to Florida red tides: Effects on emergency room respiratory diagnoses admissions.
- Author
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Kirkpatrick B, Fleming LE, Backer LC, Bean JA, Tamer R, Kirkpatrick G, Kane T, Wanner A, Dalpra D, Reich A, and Baden DG
- Abstract
Human exposure to Florida red tides formed by Karenia brevis, occurs from eating contaminated shellfish and inhaling aerosolized brevetoxins. Recent studies have documented acute symptom changes and pulmonary function responses after inhalation of the toxic aerosols, particularly among asthmatics. These findings suggest that there are increases in medical care facility visits for respiratory complaints and for exacerbations of underlying respiratory diseases associated with the occurrence of Florida red tides.This study examined whether the presence of a Florida red tide affected the rates of admission with a respiratory diagnosis to a hospital emergency room in Sarasota, FL. The rate of respiratory diagnoses admissions were compared for a 3-month time period when there was an onshore red tide in 2001 (red tide period) and during the same 3-month period in 2002 when no red tide bloom occurred (non-red tide period). There was no significant increase in the total number of respiratory admissions between the two time periods. However, there was a 19% increase in the rate of pneumonia cases diagnosed during the red tide period compared with the non-red tide period. We categorized home residence zip codes as coastal (within 1.6 km from the shore) or inland (>1.6 km from shore). Compared with the non-red tide period, the coastal residents had a significantly higher (54%) rate of respiratory diagnoses admissions than during the red tide period. We then divided the diagnoses into subcategories (i.e. pneumonia, bronchitis, asthma, and upper airway disease). When compared with the non-red tide period, the coastal zip codes had increases in the rates of admission of each of the subcategories during the red tide period (i.e. 31, 56, 44, and 64%, respectively). This increase was not observed seen in the inland zip codes.These results suggest that the healthcare community has a significant burden from patients, particularly those who live along the coast, needing emergency medical care for both acute and potentially chronic respiratory illnesses during red tide blooms.
- Published
- 2006
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