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Objectives: Multiple sclerosis (MS) is the most common neurological disease that causes disability in the nervous system, which reduces the quality of life (QoL). Studies have shown positive effects of therapeutic exercise with supplementation on motor- and cognitive function, fatigue, and QoL in individuals with MS. The purpose of this study was to investigate the effect of home-based aerobic training (AT) and vitamin D (Vit D) supplementation on fatigue and QoL in patients with MS during the COVID-19 outbreak., Equipment and Methods: We recruited 40 females (20-40 years) with MS (EDSS: 3-5). The subjects were then randomly assigned to one of four groups: AT ( n  = 9; 50-75 percent, 20-40 minutes per day, three days per week), Vit D supplementation (Vit D; n  = 9; 50,000 IU one day per week), AT plus Vit D supplementation (AT + Vit D; n  = 10), and sedentary control (C; n  = 10 placebo). The data were analyzed using paired  t -test and one-way analysis of variance and Tukey's post hoc test using SPSS 26 at a significance level of P  < 0.05., Results: After eight weeks of intervention, fatigue grade markedly reduced in the AT + Vit D, AT, and Vit D groups); However, fatigue increased in the control group. QoL increased significantly in AT + Vit D, AT, and Vit D compared to C. Also, the results show that the AT + Vit D had significantly higher QoL than AT and Vit D. These findings suggest that therapeutic AT and Vit D supplementation effectively reduces fatigue and improves the QoL in female MS patients., (© 2022 Elsevier Masson SAS. All rights reserved.)

In the present study, the potential of doxorubicin hydrochloride (DOX)-loaded electrospun chitosan/cobalt ferrite/titanium oxide nanofibers was studied to investigate the simultaneous effect of hyperthermia and chemotherapy against melanoma cancer B16F10 cell lines. The cobalt ferrite nanoparticles were synthesized via microwave heating method. The titanium oxide nanoparticles were mixed with cobalt ferrite to control the temperature rise. The synthesized nanoparticles and nanofibers were characterized using X-ray diffraction (XRD), field emission scanning electron microscopy (FESEM), and vibrating sample magnetometer (VSM) analysis. The DOX loading efficiency and in vitro drug release of DOX from nanofibers were investigated at both physiological and acidic conditions by an alternating of magnetic field and without magnetic field effect. The fastest release of DOX from prepared magnetic nanofibers was observed at acidic pH by alternating of magnetic field. The antitumor activity of synthesized nanofibers was also investigated on the melanoma cancer B16F10 cell lines. The obtained results revealed that the DOX loaded-electrospun chitosan/cobalt ferrite/titanium oxide nanofibers can be used for localized cancer therapy., (Copyright © 2018 Elsevier B.V. All rights reserved.)