1. Oral local drug delivery and new perspectives in oral drug formulation
- Author
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Carlo Paderni, Libero Italo Giannola, Giuseppina Campisi, Domenico Compilato, Paderni, C, Compilato, D, Giannola, LI, and Campisi G
- Subjects
medicine.medical_specialty ,Chemistry, Pharmaceutical ,Bioadhesive ,Administration, Sublingual ,Pharmaceutical Preparations, Dental ,Pharmacology ,Permeability ,Dosage form ,Pathology and Forensic Medicine ,Drug Delivery Systems ,Settore MED/28 - Malattie Odontostomatologiche ,Adhesives ,Administration, Mucosal ,Humans ,Medicine ,Radiology, Nuclear Medicine and imaging ,Dentistry (miscellaneous) ,Pharmaceutical sciences ,Oral mucosa ,Intensive care medicine ,Dosage Forms ,business.industry ,Mouth Mucosa ,Administration, Buccal ,Buccal administration ,Drug delivery, Buccal mucosa, Buccal dosage forms ,medicine.anatomical_structure ,Settore CHIM/09 - Farmaceutico Tecnologico Applicativo ,Drug delivery ,Surgery ,Oral Surgery ,business ,Retention time ,Oral retinoid - Abstract
Modern pharmaceutical science has provided us with a wide range of substances to be administered with a wide large variety of dosage forms. Local drug delivery systems have been used for a long time; in particular, for the local therapy of diseases affecting the oral cavity. Although these diseases are often extremely responsive to local therapy, the mouth often presents various difficulties in the application of topical compounds (owing to saliva and the mouth's different functions), resulting in a short retention time of dosage forms with a consequent low therapeutic efficacy. To resolve these limitations, research today concentrates on the development of bioadhesive formulations. This review focuses on the permeability features of oral mucosa, the rationale of oral local drug delivery, and new potential bioadhesive local delivery systems. Furthermore, the most promising mucoadhesive systems proposed to locally treat oral diseases are discussed.
- Published
- 2012