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Your search keyword '"Carlos Fontes Ribeiro"' showing total 6 results
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6 results on '"Carlos Fontes Ribeiro"'

1. Contributors

Author

Michelle M. Adams, Cédric Albinet, Banu Alicioglu, Paolo Amami, Nathalie André, Narin Ilgim Ardic-Avci, Elizabeth Arslanoglou, Guilherme Giannini Artioli, Michel Audiffren, Hande Ozge Aydogan, Francisco Javier Belchí, Marvin H. Berman, Ondrej Bezdicek, Cynthia Bianco, Jasmina Boban, Carlos Roberto Bueno Júnior, Blake E. Butler, Daniele Cartelli, Augusto Pietro Casani, Dilan Celebi-Birand, Zikuan Chen, Zeyuan Chen, Bihong T. Chen, Katie E. Cherry, Christian Chicherio, Jeshya A. Chio, Pere Clavé, Victoria C. Cogger, Márcia Regina Cominetti, Ma Fe P. de Guzman, Maria Clarissa O. del Moral, Eimear Dolan, Jacqueline C. Dominguez, Premchand Dommaraju, Theresa Ebo, Melissa K. Edler, Begun Erbaba, Ghazaleh Eskandari-Sedighi, Delphine Fagot, Fereshteh Farajdokht, Isabel Fariñas, Laís Francielle Francisca Felício, Luiz Felipe da Silva Figueiredo, Karen L. Fortuna, Máximo Ibo Galindo, Ekavi N. Georgousopoulou, Rahul Gokarn, Gabriel Gold, Hayley Groetz, Bruno Gualano, G.M. Halliday, Erin E. Harrington, Claudia Heidenreich, Boris Henčić, Rafael Hernández, Björn Herrmann, Jasna Jančić, R.C. Jeżewski, Hulusi Kafaligonul, Hakki Muammer Karakas, Elif Tugce Karoglu-Eravsar, Dimitris Kiosses, Dusko Kozic, Enikö Kövari, Lewis H. Kuller, Thomas J. LaRocca, David G. Le Couteur, Gary Jek Chong Lee, Unax Lertxundi, Víctor López del Amo, Mariana Luciano de Almeida, Javad Mahmoudi, João O. Malva, Patricia Regina Manzine, Beatriz Martins, Douglas B. Matthews, Derval McCormack, Juan Medrano, Duane D. Mellor, Juan C. Meléndez, Jonas Mengel-From, Jelena Milić, Jody Monkovic, Renato Sobral Monteiro-Junior, Ricardo Moreira, Emily L. Munger, Elena Navari, M. Christopher Newland, João Novo, Reinaldo B. Oriá, Fiadhnait O’Keeffe, Demosthenes B. Panagiotakos, Frederico C. Pereira, Ana Perez-Villalba, Rafaela Peron, Victor R. Preedy, Mary Ann Raghanti, Simona Raimo, Rajkumar Rajendram, Ana López Ramírez, Ramon Raposo, David Raubenheimer, Punam Rawal, Celinda Reese-Melancon, Hannah Reich, Carmen Requena, Carlos Fontes Ribeiro, Ana Carolina de Mello Alves Rodrigues, Luis Miguel Rondón García, Rosa Raquel Ruiz Trascastro, Saeed Sadigh-Eteghad, Farzad Salehpour, Janko Samardžić, Gabriella Santangelo, Encarnación Satorres, Andrew N. Shen, C.E. Shepherd, Stephen J. Simpson, Marina Yazigi Solis, Samantha M. Solon-Biet, Dunja Stankić, Timo E. Strandberg, Astrid M. Suchy-Dicey, Andrea Tapia, Majda M. Thurnher, Paula Álvarez-Merino, Noemí Tomsen, Luigi Trojano, Melek Umay Tuz-Sasik, Henryk F. Urbanski, Rodrigo Portes Ureshino, Ed van Beeck, Candice E. Van Skike, Izabela Pereira Vatanabe, Devin Wahl, David Westaway, Shawn Wong, Long Wu, Túlio Brandão Xavier-Rocha, Janko Zeković, Xin Zhang, and Liqin Zhao

Published
2021
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2. Neuroinflammation and aging

Author

Frederico C. Pereira, Beatriz Martins, Ramon da Silva Raposo, João P Novo, Reinaldo B. Oriá, João O. Malva, Ricardo Moreira, and Carlos Fontes Ribeiro

Subjects
business.industry, Medicine, business, Neuroscience, Neuroinflammation
Published
2021
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3. Layer-by-Layer coated drug-core nanoparticles as versatile delivery platforms

Author

Francisco Veiga, Carlos Fontes Ribeiro, Mariana Caldas, António J. Ribeiro, Pravin Pattekari, Yuri Lvov, and Ana Cláudia Santos

Subjects
Drug, Materials science, media_common.quotation_subject, Layer by layer, Nanoparticle, Nanotechnology, 02 engineering and technology, engineering.material, 010402 general chemistry, 021001 nanoscience & nanotechnology, 01 natural sciences, Nanocapsules, Polyelectrolyte, 0104 chemical sciences, Coating, Drug delivery, engineering, Nanocarriers, 0210 nano-technology, media_common
Abstract

The Layer-by-Layer (LbL) deposition procedure is a versatile technique, based on the sequential deposition of complementary molecular species on colloidal surfaces. The attachment of the LbL coating upon drug nanocore surfaces creates a multilayered thin core-shell nanocapsule. Owing to the electrostatic main driving force for multilayer LbL shell build-up, a wide variety of shell constituents can be used, ranging from synthetic to naturally derived polyelectrolytes, lipids, enzymes, viruses, colloids and other active compounds. These multilayered films allow the combination of several different materials at the nanoscale in a single unit, giving rise to novel and multifunctional architectures capable of performing numerous tasks required for systemic drug delivery. These features allow the possibility of drug protection and high drug loadings, together with drug release tuning capacities from the core by modulating the LbL coating permeability. This chapter is a comprehensive revision of recent LbL deposition applications on drug nanocores as strategic nanocarriers for drug delivery. The different methods and coating materials used in the preparation of the LbL nanocapsules, as well as recent advances in releasing encapsulated drugs through LbL nanocapsules, are exposed and discussed. In addition to these topics, the LbL pharmaceutical applications, their advantages and challenges, with particular emphasis on the advances of recent years by in vitro and in vivo studies, as well as the toxicological issues out of their use and future perspectives are addressed.

Published
2018
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4. List of Contributors

Author

Semra Akgönüllü, Cláudia Amaral, Dilek Battal, Oguz Bayraktar, Mariana Caldas, Raúl Cazorla-Luna, Kemal Çetin, Ramesh Chandra, Beata Chudzik-Rząd, Manuel A.N. Coelho, Grazia M.L. Consoli, Nily Dan, Costas Demetzos, Adil Denizli, Leonardo M.B. Ferreira, Ana Figueiras, Corrada Geraci, Giuseppe Granata, Maria Palmira D. Gremião, Nidhi Gupta, Hiroshi Handa, Özge K. Heinz, Aleksandr I. Ilin, Muhammad Imran, Sougata Jana, Masaaki Kawano, Sepideh Khoee, Charlene P. Kiill, Merve D. Köse, R. Mankamna Kumari, Bibek Laha, Yuri Lvov, Mariana Magalhães, Sabyasachi Maiti, Araceli Martín-Illana, Masanori Matsui, Surendra Nimesh, Fernando Notario-Pérez, Akram Nouri, Pravin Pattekari, Liliane N. Pedreiro, Maria C. Pereira, Natassa Pippa, Stergios Pispas, Maria J. Ramalho, Andreza M. Ribeiro, António José Ribeiro, Carlos Fontes Ribeiro, Roberto Ruiz-Caro, Aline M. Santos, Ana Cláudia Santos, null Shafiullah, Muhammad R. Shah, Nikita Sharma, Jan Sobczyński, Francisco Veiga, María-Dolores Veiga, Handan Yavuz, Gulnara A. Yuldasheva, and Georgii M. Zhidomirov

Published
2018
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5. Endothelial progenitor cells in diabetic patients with myocardial infarction – Can statins improve their function?

Author

Tiago Carvalheiro, Rosa Fernandes, Lino Gonçalves, Luís A. Providência, Ana Paula Lopes, Ana Soares, Natália António, Francisco Soares, Artur Paiva, and Carlos Fontes Ribeiro

Subjects
Senescence, Adult, Male, medicine.medical_specialty, Atorvastatin, CD34, Myocardial Infarction, Neovascularization, Physiologic, CXCR4, Diabetes mellitus, Internal medicine, medicine, Humans, Myocardial infarction, Prospective Studies, cardiovascular diseases, Progenitor cell, Function, Cells, Cultured, Endothelial progenitor cells, Aged, Endothelial Progenitor Cells, Pharmacology, business.industry, Statins, Middle Aged, medicine.disease, Endocrinology, Diabetes Mellitus, Type 2, embryonic structures, cardiovascular system, Female, Hydroxymethylglutaryl-CoA Reductase Inhibitors, business, Pravastatin, medicine.drug, circulatory and respiratory physiology
Abstract

The effect of statins on endothelial progenitor cells (EPCs) function derived from diabetic patients (DMpts) with acute myocardial infarction (AMI) is unknown. In this study we assess the response of early and late EPCs from diabetic versus non-diabetic patients (NDMpts) with AMI to statins. EPCs were obtained from 10 diabetic and 10 age-matched non-diabetic male patients with AMI. For each patient, cultures of early and late EPCs were performed under 4 different conditions: normal glucose concentration (control); high glucose concentration; normal glucose concentration with atorvastatin supplementation and normal glucose concentration with pravastatin supplementation. To compare the effect of these treatments on EPC function in DMpts versus NDMpts, we performed in vitro: EPC colony-forming units (CFU) assay; cell cycle analysis; viability assessment and expression of the surface markers CXCR4, CD133, CD34 and KDR. Under control conditions, CFU numbers were reduced in DMpts-derived EPCs when compared to those of NDMpts (1.4±0.8 vs 2.6±1.2 CFU/well, P=0.021). When early EPCs from DMpts were cultured in the presence of statins, CFU capacity was restored, surmounting that of NDMpts under control conditions. Statins significantly improved viability of early EPCs and delayed the onset of late EPCs senescence, even in cells from DMpts. In addition, statins induced approximately a 2-fold increase in the proportion of late EPCs in S-phase of the cell cycle (P

Published
2014

6. Methamphetamine decreases dentate gyrus stem cell self-renewal and shifts the differentiation towards neuronal fate

Author

Sofia Baptista, Charlène Lasgi, Caroline Benstaali, Nuno Milhazes, Fernanda Borges, Carlos Fontes-Ribeiro, Fabienne Agasse, and Ana Paula Silva

Subjects
Biology (General), QH301-705.5
Abstract

Methamphetamine (METH) is a highly addictive psychostimulant drug of abuse that negatively interferes with neurogenesis. In fact, we have previously shown that METH triggers stem/progenitor cell death and decreases neuronal differentiation in the dentate gyrus (DG). Still, little is known regarding its effect on DG stem cell properties. Herein, we investigate the impact of METH on mice DG stem/progenitor cell self-renewal functions. METH (10 nM) decreased DG stem cell self-renewal, while 1 nM delayed cell cycle in the G0/G1-to-S phase transition and increased the number of quiescent cells (G0 phase), which correlated with a decrease in cyclin E, pEGFR and pERK1/2 protein levels. Importantly, both drug concentrations (1 or 10 nM) did not induce cell death. In accordance with the impairment of self-renewal capacity, METH (10 nM) decreased Sox2+/Sox2+ while increased Sox2−/Sox2− pairs of daughter cells. This effect relied on N-methyl-d-aspartate (NMDA) signaling, which was prevented by the NMDA receptor antagonist, MK-801 (10 μM). Moreover, METH (10 nM) increased doublecortin (DCX) protein levels consistent with neuronal differentiation. In conclusion, METH alters DG stem cell properties by delaying cell cycle and decreasing self-renewal capacities, mechanisms that may contribute to DG neurogenesis impairment followed by cognitive deficits verified in METH consumers.

Published
2014
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