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14 results on '"Casalino, G."'

2. Fiber laser-MAG hybrid welding of DP/AISI 316 and TWIP/AISI 316 dissimilar weld

Author

Casalino, G., Angelastro, A., Perulli, P., Posa, P., Spena, P. R., and RUSSO SPENA, Pasquale

Subjects
0209 industrial biotechnology, Heat-affected zone, Materials science, AISI 316 steel, Twip, 02 engineering and technology, Welding, 010501 environmental sciences, engineering.material, 01 natural sciences, law.invention, 020901 industrial engineering & automation, law, microstructural characterization, Ultimate tensile strength, Hybrid laser arc welding, Austenitic filler, Dissimilar weld, DP steel, Mechanical, Twip steel, Composite material, Austenitic stainless steel, Ductility, 0105 earth and related environmental sciences, General Environmental Science, Austenite, engineering, General Earth and Planetary Sciences, Arc welding
Abstract

In this paper, TWinning-Induced Plasticity (TWIP), Dual Phase (DP) and austenitic stainless (AISI 316) steels were joined together by hybrid laser/arc welding with an austenitic steel filler. Microstructural and mechanical characterization of welded joints was carried out by optical microscopy, microhardness, tensile and bend tests. The heat affected zone (HAZ) at the TWIP side was fully austenitic and exhibited a grain coarsening; at the DP side, new martensite formed close to the fusion zone and other phase transformations occurred moving toward the base metal; at the AISI 316 side, stringers of untreated ferrite δ inside the austenitic matrix was observed. All the tensile welded specimens broke within austenitic stainless steel. TWIP/AISI 316 welds exhibited a greater tensile strength than DP/AISI 316 ones. The bending tests confirmed the ductility of both sorts of joints.

Published
2019

13. Mechanical and microstructure analysis of AA6061 and Ti6AI4V fiber laser butt weld

Author

Gianfranco Palumbo, Antonio Piccininni, Paola Leo, Giuseppe Casalino, Sonia D'Ostuni, Michelangelo Mortello, Pasquale Guglielmi, Casalino, G., D'Ostuni, S., Guglielmi, P., Leo, P., Mortello, M., Palumbo, G., and Piccininni, A.

Subjects
0209 industrial biotechnology, Heat-affected zone, Materials science, Butt welding, 02 engineering and technology, Welding, law.invention, Flash welding, 020901 industrial engineering & automation, law, Atomic and Molecular Physics, Electronic, Dissimilar weld, Fiber laser welding, Mechanical and microstructure properties, Electronic, Optical and Magnetic Materials, Atomic and Molecular Physics, and Optics, Electrical and Electronic Engineering, Optical and Magnetic Materials, Composite material, Base metal, Groove (music), Filler metal, 021001 nanoscience & nanotechnology, Butt joint, and Optics, 0210 nano-technology
Abstract

Dissimilar metal welding involves the joining of two or more different pure metals or alloys, usually by melting and mixing and often with the addition of filler metal. There are several types of dissimilar metal welds including stainless steel, either as base metal or as filler metals. Dissimilar metal joints have distinctive features because of differences in the chemical composition of base metal and filler material. Their alloying elements will diffuse intensely during welding. The structures near the fusion line are very complex. Despite of great potentiality in aircraft and automotive industries, dissimilar joining of hybrid Al-Ti structures is often challenging because of the unavoidable formation of brittle intermetallic compounds, mixing of molten phases, and significant differences in material properties. In this work, dissimilar 2 mm thickness AA6000 and Ti6Al4V butt joints were produced by shifting an Yb fiber laser beam on the upper surface of the Ti sheet. Neither filler wire nor groove preparation was adopted. Different working conditions and seam shapes were assessed. The welds were characterized in terms of metallurgical and mechanical behaviors.

Published
2017

14. Autosomal Recessive Bestrophinopathy: Clinical Features, Natural History, and Genetic Findings in Preparation for Clinical Trials.

Author

Casalino G, Khan KN, Armengol M, Wright G, Pontikos N, Georgiou M, Webster AR, Robson AG, Grewal PS, and Michaelides M

Subjects
Adolescent, Adult, Child, Child, Preschool, Clinical Trials as Topic, Cone-Rod Dystrophies physiopathology, Electrophysiology, Eye Diseases, Hereditary physiopathology, Female, Genes, Recessive, Humans, Male, Middle Aged, Molecular Biology, Optical Imaging, Phenotype, Retinal Diseases physiopathology, Retrospective Studies, Tomography, Optical Coherence, Visual Acuity physiology, Bestrophins genetics, Eye Diseases, Hereditary diagnosis, Eye Diseases, Hereditary genetics, Retinal Diseases diagnosis, Retinal Diseases genetics
Abstract

Purpose: To investigate the clinical course, genetic findings, and phenotypic spectrum of autosomal recessive bestrophinopathy (ARB) in a large cohort of children and adults., Design: Retrospective case series., Participants: Patients with a detailed clinical phenotype consistent with ARB, biallelic likely disease-causing sequence variants in the BEST1 gene, or both identified at a single tertiary referral center., Methods: Review of case notes, retinal imaging (color fundus photography, fundus autofluorescence, OCT), electrophysiologic assessment, and molecular genetic testing., Main Outcome Measures: Visual acuity (VA), retinal imaging, and electrophysiologic changes over time., Results: Fifty-six eyes of 28 unrelated patients were included. Compound heterozygous variants were detected in most patients (19/27), with 6 alleles recurring in apparently unrelated individuals, the most common of which was c.422G→A, p.(Arg141His; n = 4 patients). Mean presenting VA was 0.52 ± 0.36 logarithm of the minimum angle of resolution (logMAR), and final VA was 0.81 ± 0.75 logMAR (P = 0.06). The mean rate of change in VA was 0.05 ± 0.13 logMAR/year. A significant change in VA was detected in patients with a follow-up of 5 years or more (n = 18) compared with patients with a follow-up of 5 years or less (n = 10; P = 0.001). Presence of subretinal fluid and vitelliform material were early findings in most patients, and this did not change substantially over time. A reduction in central retinal thickness was detected in most eyes (80.4%) over the course of follow-up. Many patients (10/26) showed evidence of generalized rod and cone system dysfunction. These patients were older (P < 0.001) and had worse VA (P = 0.02) than those with normal full-field electroretinography results., Conclusions: Although patients with ARB are presumed to have no functioning bestrophin channels, significant phenotypic heterogeneity is evident. The clinical course is characterized by a progressive loss of vision with a slow rate of decline, providing a wide therapeutic window for anticipated future treatment strategies., (Copyright © 2020 American Academy of Ophthalmology. Published by Elsevier Inc. All rights reserved.)

Published
2021
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