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2. LIST OF CONTRIBUTORS

Author

Abu-Shakra, Mahmoud, primary, Achiron, Anat, additional, Alderuccio, Frank, additional, Amital, Howard, additional, Ansari, Aftab A., additional, Aoki, Christopher A., additional, Arepally, Gowthami, additional, Aries, Peer M., additional, Atzeni, Fabiola, additional, Bachmann, Michael, additional, Bendtzen, Klaus, additional, Berden, Jo H., additional, Bertolaccini, Maria Laura, additional, Betterle, Corrado, additional, Bianchi, Francesco B., additional, Binder, Steven R., additional, Bizzaro, Nicola, additional, Borghi, Maria O., additional, Bowlus, Christopher L., additional, Božič, Borut, additional, Bradwell, Arthur R., additional, Bruschi, Maurizio, additional, Burek, C. Lynne, additional, Candiano, Giovanni, additional, Carp, H.J.A., additional, Caturegli, Patrizio, additional, Cerinic, Marco Matucci, additional, Cervera, Ricard, additional, Chan, Edward K.L., additional, Chang, Yih-Hsin, additional, Chen, Shu, additional, Cicardi, Marco, additional, Cines, Douglas B., additional, Cohen, Irun R., additional, Conrad, Karsten, additional, Csernok, Elena, additional, Čučnik, Saša, additional, De Angelis, Valentina, additional, Dier, Ken J., additional, Dotan, Nir, additional, Dueymes, Maryvonne, additional, Dumortier, Hélène, additional, Lahawi, Mohammed El, additional, Faulk, W. Page, additional, Feist, Eugen, additional, Forster, Olaf, additional, Fritzler, Marvin J., additional, Frostegård, Johan, additional, Fujinami, Robert S., additional, Furmaniak, Jadwiga, additional, Galli, Monica, additional, Gerosa, Maria, additional, Gershwin, M. Eric, additional, Ghiggeri, Gian Marco, additional, Gilles, Jean Guy, additional, Grando, Sergei A., additional, Graus, Francesc, additional, Gross, Wolfgang L., additional, Guiducci, Serena, additional, Guilpain, Philippe, additional, Hamann, Dörte, additional, Hamilton, Robert G., additional, Harel, Michal, additional, Haung, Ming-Lih, additional, Heidenreich, Fedor, additional, Hellmark, Thomas, additional, Herkel, Johannes I., additional, Hershko, Alon Y., additional, Hiepe, Falk, additional, Hilfiker-Kleiner, Denise, additional, Hughes, Richard G., additional, Hultman, Per, additional, Invernizzi, Pietro, additional, Izui, Shozo, additional, Jirawuthiworavong, Guy V., additional, Kallenberg, Cees G.M., additional, Karim, Abid R., additional, Kaveri, Srinivas V., additional, Khamashta, Munther A., additional, Kind, Michaela, additional, Knoflach, Michael, additional, Kodermaz, Graziano, additional, Krueger, Christian, additional, Kveder, Tanja, additional, Landolfo, Santo, additional, Lang, Bethan, additional, Leung, Patrick S.C., additional, Levy-Clarke, Grace A., additional, Lindert, Ralf-Björn, additional, Lochman, Ivo, additional, Lochmanová, Alexandra, additional, Lopez, Luis R., additional, Loy, Anthony Chin, additional, Manns, Michael P., additional, Matsumoto, Isao, additional, Matsuura, Eiji, additional, McCarty, Gale A., additional, McHugh, Neil John, additional, McIntyre, John A., additional, Meroni, Pier Luigi, additional, Miron, Shmuel, additional, Mondini, Michele, additional, Mouthon, Luc, additional, Muller, Sylviane, additional, Muratori, Paolo, additional, Musante, Luca, additional, Muthugounder, Sakunthala, additional, Naguwa, Stanley, additional, Nakamura, Tomomi, additional, Naparstek, Yaakov, additional, Narain, Sonali, additional, Nussenblat, Robert B., additional, Nydegger, Urs E., additional, Oertelt, Sabine, additional, Pengo, Vittorio, additional, Peterson, Lisa K., additional, Pietropaolo, Massimo, additional, Podda, Mauro, additional, Pollard, K. Michael, additional, Poncz, Mortimer, additional, Prestigiacomo, Tony, additional, Radice, Antonella, additional, Randone, Silvia Bellando, additional, Raschi, Elena, additional, Ravindranath, Mepur H., additional, Ravindranath, Rajeswari M.H., additional, Reeves, Westley H., additional, Reichlin, Morris, additional, Renaudineau, Yves, additional, Riboldi, Piersandro, additional, Ronda, Nicoletta, additional, Rose, Noel R., additional, Rosenberg, Nurit, additional, Routsias, John G., additional, Rozman, B., additional, Ruffatti, Amelia, additional, Sabadini, Ettore, additional, Saint-Remy, Jean-Marie, additional, Salomon, Ophira, additional, Santucci, Laura, additional, Sarzi-Puttini, Piercarlo, additional, Satoh, Minoru, additional, Schlosser, Michael, additional, Scofield, R. Hal, additional, Segelmark, Mårten, additional, Selmi, Carlo, additional, Seo, Suk, additional, Shenkman, Boris, additional, Shiau, Ming-Yuh, additional, Shoenfeld, Yehuda, additional, Sinico, Renato Alberto, additional, Sliwa, Karen, additional, Smeenk, Ruud J.T., additional, Smolen, Josef S., additional, Sperling, Mark A., additional, Stadler, Beda M., additional, Steiner, Günter, additional, Stöcker, Winfried, additional, Strassburg, Christian P., additional, Sumida, Takayuki, additional, Sundstrom, J. Bruce, additional, Svenson, Morten, additional, Targoff, Ira N., additional, Tedesco, Francesco, additional, Toh, Ban-Hock, additional, Tonutti, Elio, additional, Torens, Isabel, additional, Torok, Natalie, additional, Tozzoli, Renato, additional, Tsokos, George C., additional, Tzioufas, Athanasios G., additional, Ulmansky, Rina, additional, van Bavel, Casandra C., additional, van der Vlag, Johan, additional, Villalta, Danilo, additional, Vincent, Angela, additional, Wagenknecht, Dawn R., additional, Wakamatsu, Ei, additional, Wener, Mark H., additional, Wesierska-Gadek, Józefa, additional, Wick, Georg, additional, Wiik, Allan, additional, Willison, Hugh J., additional, Witte, Torsten, additional, Wurster, Ulrich, additional, Youinou, Pierre, additional, Zanchetta, Renato, additional, Zandman-Goddard, Gisele, additional, Zhuang, Haoyang, additional, Zingale, Lorenza C., additional, and Zuliani, Luigi, additional

Published
2007
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4. List of Contributors

Author

Abu-Shakra, Mahmoud, primary, Achiron, Anat, additional, Adelman, Miranda K., additional, Afanasyeva, Marina, additional, Akaogi, Jun, additional, Alcocer-Varela, Jorge, additional, Amedei, Amedeo, additional, Appelmelk, Ben J., additional, Aron-Maor, Anabel, additional, Asherson, Ronald A., additional, van den Berg, Leonard H., additional, Bergman, Mathijs P., additional, Blank, M., additional, Bombardieri, Stefano, additional, Buc, Milan, additional, Bussel, James, additional, Cainelli, Francesco, additional, Cervera, Ricard, additional, Chou, Alexander J., additional, Cohen, Irun R., additional, Cohen, Pascal, additional, Acuña, J.C. Crispin, additional, Cunha-Neto, Edecio, additional, Cutolo, Maurizio, additional, David, Michael, additional, D'Elios, Mario M., additional, Del Prete, Gianfranco, additional, Denman, A.M., additional, Detrick, Barbara, additional, Doria, Andrea, additional, Dugué, C., additional, Durai, Malarvizhi, additional, Ebringer, Alan, additional, Eisenstein, Miriam, additional, Ferri, Clodoveo, additional, Frostegård, Johan, additional, Gambari, Pier Franca, additional, Garvey, Marjorie A., additional, Gershwin, M. Eric, additional, Ghirardello, Anna, additional, Giacomelli, Roberto, additional, Guiducci, Serena, additional, Fonseca, Simone Gonçalves, additional, Guilherme, Luiza, additional, Guillevin, Loïc, additional, Hafler, David A., additional, Hatemi, Gülen, additional, He, Xiao-Song, additional, Hooks, John J., additional, Iaccarino, Luca, additional, Jacobson, Steven, additional, Jansen, M.D., additional, Jara, Luis J., additional, Jun, Hee-Sook, additional, Kalil, Jorge, additional, Kapsogeorgou, Efstathia K., additional, Iwai, Leo Kei, additional, Kelly, Kindra M., additional, Krause, Ilan, additional, Krebs, Philippe, additional, Kuroda, Yoshiki, additional, Lerner, Aaron, additional, Liakos, Dimitrios A., additional, Lim, Dong-Gyun, additional, Ludewig, Burkhard, additional, Marchalonis, John J., additional, Cerinic, Marco Matucci, additional, Medina, Gabriela, additional, Miller, Stephen D., additional, Milo, Gui, additional, Mimouni, Daniel, additional, Miranda, Juan M., additional, Bilate, Angelina Morand B., additional, Moudgil, Kamal D., additional, Moutsopoulos, Haralampos M., additional, Nacionales, Dina C., additional, Navarro, Carmen, additional, Nussenblatt, Robert, additional, Pagnoux, Christian, additional, Pender, Michael P., additional, Pers, Jaques-Olivier, additional, van der Pol, W-Ludo, additional, Prummel, Mark F., additional, Quintana, Francisco J., additional, Rager-Zisman, B., additional, Rashid, Taha, additional, Reeves, Westley H., additional, Reif, Shimon, additional, Renaudineau, Yves, additional, Rose, Noel R., additional, Rovenský, Jozef, additional, Satoh, Minoru, additional, Schmidt, Reinhold E., additional, Seriolo, Bruno, additional, Severin, Marianne C., additional, Shoenfeld, Yehuda, additional, Sibilia, Jean, additional, Snider, Lisa A., additional, Soldan, Samantha S., additional, Sorge, N.M. van, additional, Steere, Allen C., additional, Stoll, Matthias, additional, Sulli, Alberto, additional, Swedo, Susan E., additional, Tishler, Moshe, additional, Tomer, Yaron, additional, Tyndall, Alan, additional, Vandenbroucke-Grauls, Christina M., additional, VanderLugt-Castaneda, Carol L., additional, Vassilopoulos, Dimitrios, additional, Vento, Sandro, additional, Vera-Lastra, Olga, additional, Villanueva, Ronald, additional, Wachsmann, Dominique, additional, Weinstock, Joel V., additional, Wick, Georg, additional, Wiersinga, Wilmar M., additional, Wilson, Clyde, additional, van de Winkel, Jan G.J., additional, Wucherpfennig, Kai W., additional, Xu, Qingbo, additional, Yazici, Hasan, additional, Yocum, David E., additional, Yoon, Ji-Won, additional, Youinou, Pierre, additional, Zampieri, Sandra, additional, and Zandman-Goddard, Gisele, additional

Published
2004
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6. Systemic sclerosis and infections.

Author

Randone SB, Guiducci S, and Cerinic MM

Subjects
Antigens, Bacterial, Antigens, Viral, Chimerism, Endothelial Cells pathology, Fibrosis, Helicobacter Infections, Helicobacter pylori, Herpesviridae, Humans, Immunity, Innate, Molecular Mimicry, Parvovirus B19, Human, Retroviridae, Scleroderma, Systemic physiopathology, Superantigens, Endothelial Cells metabolism, Herpesviridae Infections immunology, Parvoviridae Infections immunology, Retroviridae Infections immunology, Scleroderma, Systemic immunology
Abstract

Systemic sclerosis (SSc) is an autoimmune disease characterized by vascular obliteration, excessive extracellular matrix deposition and fibrosis of the connective tissues of the skin, lungs, gastrointestinal tract, heart, and kidneys. Numerous infectious agents (bacterial and viral) have been proposed as possible triggering factors (Parvovirus B19, Cytomegalovirus, Epstein-Barr virus, Retroviruses). Homology between viruses and autoantibody targets suggests that molecular mimicry may have a role in initiating antibody response in different disorders characterized by diffuse vascular disease, including SSc. Endothelial cell may be infected bacteria or viruses that play a particular role in inducing vasculitis. The pathogenic hypothesis include: a mechanism of molecular mimicry, the role played by endothelial cell damage, the presence of superantigens and the role of microchimeric cells. Although several studies provide important information linking infectious agents to SSc, a direct casual association between infections and SSc is still missing. In SSc viral products could synergize with other factors in the microenvironment predisposing to SSc development.

Published
2008
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7. Musculoskeletal involvement in systemic sclerosis.

Author

Randone SB, Guiducci S, and Cerinic MM

Subjects
Arthralgia complications, Arthralgia physiopathology, Calcinosis complications, Humans, Muscle Weakness physiopathology, Scleroderma, Systemic complications, Tenosynovitis complications, Tenosynovitis physiopathology, Calcinosis physiopathology, Musculoskeletal System physiopathology, Scleroderma, Systemic physiopathology
Abstract

Musculoskeletal involvement is more frequent than expected in patients with systemic sclerosis (SSc) and is a major cause of disability, even if the prognosis of the disease largely depends on visceral involvement. The most common clinical feature of musculoskeletal involvement is arthralgia; less frequent features are arthritis, flexion contractures, stiffness (affecting predominantly fingers, wrists and ankles), proximal muscle weakness (mainly of the shoulder and hip) and tendon sheath involvement. Tendon friction rubs are predictive of poor prognosis. If musculoskeletal involvement is suspected, serum creatinine phosphokinase, aldolase, lactate dehydrogenase, alkaline phosphate, rheumatoid factor and anticyclic citrullinated peptide autoantibodies should be checked routinely. Treatment for muscle involvement has not yet been considered adequately and, in the future, it is to be hoped that clinical trials will identify new drugs to control this aspect of SSc, which seriously compromises patients' quality of life.

Published
2008
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8. Vascular complications of scleroderma.

Author

Guiducci S, Giacomelli R, and Cerinic MM

Subjects
Animals, Humans, Scleroderma, Systemic drug therapy, Scleroderma, Systemic immunology, Vascular Diseases drug therapy, Scleroderma, Systemic complications, Vascular Diseases etiology
Abstract

Systemic sclerosis (SSc) is a multiorgan disease characterized by injury to vascular wall and extensive damage of the microvessels. The injury of the vascular wall is characterized by the formation of megacapillaries and avascular areas. The reduced capillary density leads to clinical manifestations such as digital ulcers. These lesions are extremely painful and lead to substantial functional disability. Management of digital ulcers includes non-pharmacologic and pharmacologic modalities. Despite the reduced blood flow and reduced partial oxygen pressure levels, there is paradoxically no evidence for a sufficient angiogenesis in the skin of patients with SSc. Angiogenesis is strongly disturbed in SSc, as demonstrated by Nailfold Video-Capillaroscopy changes, the damage of the vessels evolves progressively from early to late stages and is characterized by different morphological aspects. Almost all patients develop Raynaud's phenomenon which, together with structural vasculopathy, results in ulceration and critical digital ischemia. Many of the severe internal organ complications of SSc are vascular, including pulmonary arterial hypertension (PAH) and scleroderma renal crisis. Structural vascular damage occurs in many vascular beds and contribute to pulmonary, renal, cardiac and gastrointestinal complications. SSc has a high case-specific mortality due to organ-based complications including PAH, lung fibrosis, renal failure and involvement of the gastrointestinal tract.

Published
2007
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