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5 results on '"Charlie C. Hsu"'

1. List of Contributors

Author

Christian R. Abee, Walter Akers, Lynn C. Anderson, Keith M. Astrofsky, Janet Baer, David G. Baker, Henry J. Baker, Betty H. Baldwin, Stephen W. Barthold, Nicole Baumgarth, Kathryn A.L. Bayne, Bonnie V. Beaver, Christine A. Bellezza, B. Taylor Bennett, Ingrid Bergin, Ruth Blauwiekel, David W. Brammer, Marilyn J. Brown, Tanya Burkholder, Calvin B. Carpenter, Maia M. Chan, Kimberly Cheng, Thomas B. Clarkson, Charles B. Clifford, J. Mark Cline, Lesley A. Colby, Patrick W. Concannon, Lisa A. Conti, Leslie I. Curtin, Margaret L. Delano, Thomas M. Donnelly, Raimon Duran-Struuck, Robert C. Dysko, Melissa C. Dyson, Michael Y. Esmail, Paula C. Ezell, Michale S. Fee, Carmen Ledesma Feliciano, Paul Flecknell, James G. Fox, Craig L. Franklin, Alexis Garcia, Rose Gillesby, Lou Ann Graham, F. Claire Hankenson, John E. Harkness, Kristi L. Helke, Hilda Holcombe, William E. Hornbuckle, Charlie C. Hsu, Melanie Ihrig, Carlisle P. Landel, Rusty Lansford, Christian Lawrence, Steven L. Leary, Rafael Y. Lefkowitz, Kvin Lertpiriyapong, Patrick A. Lester, Neil S. Lipman, Jennifer L.S. Lofgren, Elizabeth R. Magden, Rachel D. Malcolm, Keith G. Mansfield, Robert P. Marini, Kirk J. Maurer, Joerg Mayer, Joy A. Mench, Marian G. Michaels, Emily L. Miedel, Scott A. Mischler, Daniel D. Myers, Jean A. Nemzek, Steven M. Niemi, Megan H. Nowland, Dorcas P. O’Rourke, Glen M. Otto, Mary M. Patterson, Kathleen R. Pritchett-Corning, Fred W. Quimby, Peter M. Rabinowitz, Richard J. Rahija, Carrie A. Redlich, Laura G. Reinholdt, Matthew D. Rosenbaum, Lois Roth, Howard G. Rush, Trenton R. Schoeb, Adam Schoell, Fabrizio C. Serluca, Sandra Sexton, William R. Shek, Nirah H. Shomer, Joe H. Simmons, Abigail L. Smith, Michael K. Stoskopf, Marjorie C. Strobel, James R. Swearengen, M. Michael Swindle, Michael R. Talcott, Bud C. Tennant, Wendy J. Underwood, Sue VandeWoude, Benjamin J. Weigler, Mark T. Whary, Colette L. Wheler, Ronald P. Wilson, Christina Winnicker, and A. Marissa Wolfe

Published
2015
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2. Biology and Diseases of Chinchillas

Author

Charlie C. Hsu, Colette L. Wheler, and Maia M. Chan

Subjects
Chinchilla, medicine.medical_specialty, biology, Life span, Captivity, Zoology, Audiology, biology.organism_classification, Chinchilla lanigera, biology.animal, otorhinolaryngologic diseases, medicine, Hystricognatha, Chinchillidae
Abstract

Small but persistent numbers of chinchillas have been used for research since the late 1970’s, primarily as models for acoustic research. Housing and care are similar to that of rabbits and guinea pigs, with some minor modifications. Chinchillas are docile, easy to handle, and are noted for their long life span, long gestation period, and soft dense fur, which requires regular dust-bathing for optimal health. They breed readily in captivity and suffer from very few naturally occurring diseases. This chapter outlines some relevant biological information, and describes the disease and management problems known to occur in captive chinchillas.

Published
2015
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3. Basic Experimental Methods

Author

Charlie C. Hsu, Jeleen A. Briscoe, and Angela B. Keffer

Subjects
Chinchilla, medicine.medical_specialty, biology, business.industry, Good control, Audiology, Surgery, Animal model, biology.animal, otorhinolaryngologic diseases, medicine, Sample collection, Experimental methods, business
Abstract

Publisher Summary Performing basic experimental procedures on chinchillas can be a challenge due to their small size, their unique characteristics, and the limited amount of information available on the techniques. Procedures such as handling, restraint, collection of samples, or administration of compounds can all be done relatively stress-free with minimal complications when performed appropriately by skilled personnel. A thorough understanding and knowledge of the experimental procedure should be obtained prior to initiation to ensure the task is carried out properly. This chapter highlights basic experimental methods in chinchillas. Chinchillas are typically quiet and shy rodents, which can be easily handled if done so in a calm, quiet, and gentle manner that uses the least amount of restraint but is still firm enough so that the handler has good control of the animal. Collection of blood from the jugular vein of chinchillas is generally well tolerated by the awake, unsedated, or unanesthetized animal. Administration of compounds or fluids in chinchillas may be done by a variety of routes including oral, intravenous, intramuscular, subcutaneous, intraperitoneal, or intraosseous. The chinchilla is well known for its use as an animal model for auditory research and diseases of the ear.

Published
2012
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4. List of Contributors

Author

Leanne C. Alworth, James E. Artwohl, Margaret Batchelder, Beth A. Bauer, Valerie K. Bergdall, Diana M.P. Berger, Cynthia L. Besch-Williford, Thea Brabb, David W. Brammer, Jeleen A. Briscoe, Kristie Brock, Marilyn J. Brown, Rochelle Buffenstein, Andrew Burich, Tanya H. Burkholder, Holly N. Burr, Amy Cassano, Neil D. Christensen, Kimberly Cohen, Lesley A. Colby, Dale M. Cooper, Marcelo A. Couto, Suzanne Craig, Joseph F. Curlee, Erin K. Daugherity, David DeLong, M. Susan DeVries, Robert C. Dysko, William P. Feeney, Stephen A. Felt, Judy Fenyk-Melody, Craig S. Frisk, Ronald F. Di Giacomo, Diane Gaertner, Mihai Gagea-Iurascu, Laura Gallaugher, Tracy L. Gluckman, Fady I. Guirguis, F. Claire Hankenson, Martha Hanes, Maureen Hargaden, Stephen B. Harvey, Susan Henwood, Robert F. Hoyt, Charlie C. Hsu, Richard B. Huneke, Hussein I. Hussein, Rony Kalman, Brian Karolewski, Angela B. Keffer, Lynn S. Keller, Debra Kirchner, Galila Lazarovici, Theresa M. Lee, Vanessa K. Lee, Patrick A. Lester, Stephen I. Levin, Garry Linton, Neil S. Lipman, John P. Long, Megan M. Mahoney, Brent J. Martin, Lisa Martin, James O. Marx, Kirk J. Maurer, Thomas W. Mayer, Nancy L. Merrill, Rashida M. Moore, Kathleen A. Murray, Daniel D. Myers, Katherine A. Naff, Denise Newsom, John N. Norton, Lee-Ronn Paluch, Thomas Park, Cynthia A. Pekow, Xuwen Peng, Stacy Pritt, Robert H. Quinn, Skye Rasmussen, Randall P. Reynolds, Gordon S. Roble, Gaye Ruble, Howard G. Rush, Mary Ball Sauer, Jodi A. Carlson Scholz, Heather Sedlacek, Eleazar Shafrir, Katherine A. Shuster, Jerald Silverman, Laura Singer, Bhupinder Singh, Kathleen Smiler, Gerald D. Smith, Peter C. Smith, Joanne Sohn, Harold F. Stills, Douglas K. Taylor, Peggy T. Tinkey, Rajesh K. Uthamanthil, Helen Valentine, Gerald Van Hoosier, Ida M. Washington, Steven H. Weisbroth, Cheri L. West, Wanda L. West, Bruce H. Williams, Jolaine M. Wilson, Steven R. Wilson, Felix R. Wolf, Richard Young, and Ehud Ziv

Published
2012
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5. Obstructive Lymphangitis Precedes Colitis in Murine Norovirus-Infected Stat1-Deficient Mice.

Author

Seamons A, Treuting PM, Meeker S, Hsu C, Paik J, Brabb T, Escobar SS, Alexander JS, Ericsson AC, Smith JG, and Maggio-Price L

Subjects
Animals, Caliciviridae Infections virology, Colitis metabolism, Colitis virology, Female, Interferons metabolism, Intestines virology, Liver metabolism, Liver virology, Lymphangitis metabolism, Lymphangitis virology, Mice, Mice, Knockout, Norovirus isolation & purification, Signal Transduction, Spleen metabolism, Spleen virology, Caliciviridae Infections complications, Colitis pathology, Intestines pathology, Liver pathology, Lymphangitis pathology, STAT1 Transcription Factor physiology, Spleen pathology
Abstract

Murine norovirus (MNV) is an RNA virus that can prove lethal in mice with impaired innate immunity. We found that MNV-4 infection of Stat1 -/- mice was not lethal, but produced a 100% penetrant, previously undescribed lymphatic phenotype characterized by chronic-active lymphangitis with hepatitis, splenitis, and chronic cecal and colonic inflammation. Lesion pathogenesis progressed from early ileal enteritis and regional dilated lymphatics to lymphangitis, granulomatous changes in the liver and spleen, and, ultimately, typhlocolitis. Lesion development was neither affected by antibiotics nor reproduced by infection with another enteric RNA virus, rotavirus. MNV-4 infection in Stat1 -/- mice decreased expression of vascular endothelial growth factor (Vegf) receptor 3, Vegf-c, and Vegf-d and increased interferon (Ifn)-γ, tumor necrosis factor-α, and inducible nitric oxide synthase. However, anti-IFN-γ and anti-tumor necrosis factor-α antibody treatment did not attenuate the histologic lesions. Studies in Ifnαβγr -/- mice suggested that canonical signaling via interferon receptors did not cause MNV-4-induced disease. Infected Stat1 -/- mice had increased STAT3 phosphorylation and expressed many STAT3-regulated genes, consistent with our findings of increased myeloid cell subsets and serum granulocyte colony-stimulating factor, which are also associated with increased STAT3 activity. In conclusion, in Stat1 -/- mice, MNV-4 induces lymphatic lesions similar to those seen in Crohn disease as well as hepatitis, splenitis, and typhlocolitis. MNV-4-infected Stat1 -/- mice may be a useful model to study mechanistic associations between viral infections, lymphatic dysfunction, and intestinal inflammation in a genetically susceptible host., (Copyright © 2018 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.)

Published
2018
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