1. Antibacterial endiandric acid derivatives from Beilschmiedia anacardioides.
- Author
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Chouna JR, Nkeng-Efouet PA, Lenta BN, Devkota KP, Neumann B, Stammler HG, Kimbu SF, and Sewald N
- Subjects
- Anti-Bacterial Agents chemistry, Anti-Bacterial Agents pharmacology, Bacillus subtilis drug effects, Carboxylic Acids chemistry, Carboxylic Acids pharmacology, Crystallography, X-Ray, Enterococcus faecalis drug effects, Magnetic Resonance Spectroscopy, Microbial Sensitivity Tests, Micrococcus luteus drug effects, Models, Molecular, Molecular Structure, Spectrometry, Mass, Electrospray Ionization, Spectrophotometry, Infrared, Anti-Bacterial Agents isolation & purification, Carboxylic Acids isolation & purification, Lauraceae chemistry
- Abstract
Three endiandric acid derivatives, beilschmiedic acids A, B and C were isolated from the stem bark of Beilschmiedia anacardioides together with the known beta-sitosterol. Their structures were established by means of modern spectroscopic techniques. The relative configuration of compound 1 was determined by single crystal X-ray analysis. The antibacterial activities of compounds A,B,C were evaluated in vitro against five strains of microbes. Compound C showed strong activity against Bacillus subtilis, Micrococcus luteus and Streptococcus faecalis (MICs below 23 microM). This Compound was more active than the reference antibiotic ampicillin against B. subtilis and M. luteus.
- Published
- 2009
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