5 results on '"Chu, R. M."'
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2. Overview of the Second International Workshop to define Swine Cluster of Differentiation (CD) antigens
- Author
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Lee, Rogan [0000-0001-8364-9515], Mackay, Charles R. [0000-0002-6338-7340], Saalmüller, A., Pauly, T., Lunney, J. K., Boyd, P. C., Aasted, B., Sachs, David H., Arn, S., Bianchi, A. T. J., Binns, R. M., Licence, S., Whyte, A., Blecha, F., Chen, Zhang, Chu, R. M., Davis, William, Denham, S., Yang, Huaizhi, Whittall, T., Parkhouse, R. Michael, Domínguez, Javier, Ezquerra Martínez, Ángel, Alonso, Fernando, Horstick, G., Howard, C., Sopp, P., Kim, Yoon Berm, Lipp, J., Mackay, Charles R., Magyar, A., McCullough, Kenneth C., Arriens, A., Summerfield, A., Murtaugh, M., Nielsen, Jens, Novikov, B., Pescovitz, M. D., Schuberth, H. J., Leibold, W., Schütt, C., Shimizu, M., Stokes, Christopher, Haverson, K., Bailey, M., Tlaskalova, H., Trebichavsky, I., Valpotic, I., Walker, J., Lee, Rogan, Zuckermann, F., Lee, Rogan [0000-0001-8364-9515], Mackay, Charles R. [0000-0002-6338-7340], Saalmüller, A., Pauly, T., Lunney, J. K., Boyd, P. C., Aasted, B., Sachs, David H., Arn, S., Bianchi, A. T. J., Binns, R. M., Licence, S., Whyte, A., Blecha, F., Chen, Zhang, Chu, R. M., Davis, William, Denham, S., Yang, Huaizhi, Whittall, T., Parkhouse, R. Michael, Domínguez, Javier, Ezquerra Martínez, Ángel, Alonso, Fernando, Horstick, G., Howard, C., Sopp, P., Kim, Yoon Berm, Lipp, J., Mackay, Charles R., Magyar, A., McCullough, Kenneth C., Arriens, A., Summerfield, A., Murtaugh, M., Nielsen, Jens, Novikov, B., Pescovitz, M. D., Schuberth, H. J., Leibold, W., Schütt, C., Shimizu, M., Stokes, Christopher, Haverson, K., Bailey, M., Tlaskalova, H., Trebichavsky, I., Valpotic, I., Walker, J., Lee, Rogan, and Zuckermann, F.
- Abstract
The aim of the Second International Swine. Cluster of Differentiation (CD) Workshop, supported by the Veterinary Immunology Committee (VIC) of the International Union of Immunological Societies (IUIS), was to standardize the assignment of monoclonal antibodies (mAb) reactive with porcine leukocyte differentation antigens and to define new antibody clusters. At the summary meeting of the workshop in July, 1995, revisions in the existing nomenclature for Swine CD were approved, so that the rules are now in accord with those for human and ruminant CD. Swine CD numbers will now be given to clusters of mAb to swine orthologues of human CD molecules when homology is proven by (1) suitable tissue distribution and lymphoid cell subset expression, (2) appropriate molecular mass of the antigen recognized by the mAbs, and (3) reactivity of mAbs with the cloned swine gene products, or cross-reactivity of the mAb on the human gene products. In some cases, this reactivity would not be fully proven, mainly due to the lack of cloned gene products; for these CD antigens, the respective clusters will be assigned by the prefix 'w' which will lead to 'wCD' antigens. As a result of the Second International Swine CD Workshop the assignment of 16 mAb to existing CD groups (CD2a, CD4a, CD5a, wCD6, wCD8, CD14, CD18a, wCD21, wCD25) was confirmed, and 2 mAb to existing swine workshop clusters (SWC). More importantly, for the work on the porcine immune system, was the definition of 5 new swine CD antigens, namely CD3 (recognized by 6 new mAb and 3 epitopes), CD16 (1 new mAb), wCD29 (2 mAb), CD45RA (3 mAb) and CD45RC (1 new mAb). Finally, the demarcation of two new SWC molecules in swine, SWC8 (2 mAb) and SWC9 (2 mAb) was confirmed.
- Published
- 1998
3. Overview of the first international workshop to define swine leukocyte cluster of differentiation (CD) antigens
- Author
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Mackay, Charles R. [0000-0002-6338-7340], Lunney, J. K., Walker, Karen, Goldman, T., Aasted, B., Bianchi, A. T. J., Binns, R. M., Licence, S., Bischof, R., Brandon, M., Blecha, F., Kielian, T. L., McVey, D. S., Chu, R. M., Carr, M., Howard, C., Sopp, P., Davis, William, Dvorak, Pavel, Domínguez, Javier, Canals, A., Sánchez-Vizcaíno, J. M., Kim, Yoon Berm, Laude, H., Mackay, Charles R., Magnusson, U., McCullough, Kenneth C., Misfeldt, M., Murtaugh, M., Molitor, T., Choi, C., Pabst, R., Parkhouse, R. Michael, Denham, S., Yang, Huaizhi, Pescovitz, M. D., Pospisil, R., Tlaskalova, H., Saalmüller, A., Weiland, E., Salmon, H., Sachs, David H., Arn, S., Shimizu, M., Stokes, Christopher, Stevens, K., Valpotic, I., Zuckermann, F., Husmann, R., Mackay, Charles R. [0000-0002-6338-7340], Lunney, J. K., Walker, Karen, Goldman, T., Aasted, B., Bianchi, A. T. J., Binns, R. M., Licence, S., Bischof, R., Brandon, M., Blecha, F., Kielian, T. L., McVey, D. S., Chu, R. M., Carr, M., Howard, C., Sopp, P., Davis, William, Dvorak, Pavel, Domínguez, Javier, Canals, A., Sánchez-Vizcaíno, J. M., Kim, Yoon Berm, Laude, H., Mackay, Charles R., Magnusson, U., McCullough, Kenneth C., Misfeldt, M., Murtaugh, M., Molitor, T., Choi, C., Pabst, R., Parkhouse, R. Michael, Denham, S., Yang, Huaizhi, Pescovitz, M. D., Pospisil, R., Tlaskalova, H., Saalmüller, A., Weiland, E., Salmon, H., Sachs, David H., Arn, S., Shimizu, M., Stokes, Christopher, Stevens, K., Valpotic, I., Zuckermann, F., and Husmann, R.
- Published
- 1994
4. Stimulation of smooth muscle cell proliferation by ox-LDL- and acetyl LDL-induced macrophage-derived foam cells.
- Author
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Shen CM, Mao SJ, Huang GS, Yang PC, and Chu RM
- Subjects
- Animals, Aorta chemistry, Aorta metabolism, Aorta pathology, Arteriosclerosis etiology, Arteriosclerosis metabolism, Arteriosclerosis pathology, Cell Division drug effects, Cells, Cultured, Enzyme-Linked Immunosorbent Assay, Fluorescent Antibody Technique, Indirect, Lipoproteins, LDL analysis, Male, Mice, Mice, Inbred ICR, Muscle, Smooth, Vascular cytology, Muscle, Smooth, Vascular physiology, Swine, Foam Cells drug effects, Lipoproteins, LDL pharmacology, Muscle, Smooth, Vascular drug effects
- Abstract
To test the hypothesis that LDL lacking of initial oxidation may also anticipate an essential role in the progression for atherosclerotic lesions, we studied the in vitro effect of foam cells induced by low density lipoprotein (LDL), oxidized (ox)-LDL or acetyl-LDL on smooth muscle cell (SMC) proliferation. Intraperitoneal macrophages collected from ICR mice were incubated with buffered saline LDL, ox-LDL or acetyl-LDL to induce foam cell formation. Porcine aortas with atherosclerotic lesions were collected from 5 pigs fed high cholesterol diets. The results indicate that foam cells induced by ox-LDL and acetyl-LDL, but not by LDL, promoted SMC proliferation. SMC proliferation was also increased by ruptured, ox-LDL- and acetyl-LDL- induced foam cells. Immunohistochemically, epitopes of the LDL, ox-LDL, and malondialdelyde (MDA)-LDL were present in atherosclerotic lesions, but the acetyl epitope was not. We suggest that foam cells, whether induced by the oxidized or acetyl or acetyl (unoxidized) form, play an essential role in the pathogenesis of atherosclerosis by stimulating SMC proliferation.
- Published
- 2001
- Full Text
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5. An acute pleuropneumonia in a pig caused by Chromobacterium violaceum.
- Author
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Liu CH, Chu RM, Weng CN, Lin YL, and Chi CS
- Subjects
- Acute Disease, Animals, Chromobacterium pathogenicity, Male, Pleuropneumonia microbiology, Swine microbiology, Chromobacterium isolation & purification, Pleuropneumonia veterinary, Swine Diseases microbiology
- Abstract
A 2.5-month-old, 30 kg Duroc pig died 10 days after showing clinical signs of dyspnoea and diarrhoea. Acute necrotizing and fibrinous pleuropneumonia with locally extensive lesions was found. Chromobacterium violaceum was isolated from pneumonic lung tissues and intratracheal inoculation of a pure culture into two SPF pigs reproduced lesions similar to those found in the natural infection.
- Published
- 1989
- Full Text
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