1. Assessment of the biological and pharmacological effects of the alpha nu beta3 and alpha nu beta5 integrin receptor antagonist, cilengitide (EMD 121974), in patients with advanced solid tumors.
- Author
-
Hariharan S, Gustafson D, Holden S, McConkey D, Davis D, Morrow M, Basche M, Gore L, Zang C, O'Bryant CL, Baron A, Gallemann D, Colevas D, and Eckhardt SG
- Subjects
- Angiogenesis Inhibitors pharmacokinetics, Apoptosis drug effects, Cell Adhesion Molecules blood, Cell Adhesion Molecules drug effects, Dose-Response Relationship, Drug, Endothelial Cells drug effects, Gene Expression drug effects, Humans, In Situ Nick-End Labeling, Neoplasms blood, Snake Venoms pharmacokinetics, Angiogenesis Inhibitors therapeutic use, Integrin alphaVbeta3 therapeutic use, Integrins therapeutic use, Neoplasms drug therapy, Receptors, Vitronectin therapeutic use, Snake Venoms therapeutic use
- Abstract
Background: Cilengitide, an antiangiogenic agent that inhibits the binding of integrins alpha(nu)beta(3) and alpha(nu)beta(5) to the extracellular matrix, was studied at two dose levels in cancer patients to determine the optimal biological dose., Patients and Methods: The doses of cilengitide were 600 or 1200 mg/m(2) as a 1-h infusion twice weekly every 28 days. A novel dose escalation scheme was utilized that relied upon the biological activity rate., Results: Twenty patients received 50 courses of cilengitide with no dose-limiting toxic effects. The pharmacokinetic (PK) profile revealed a short elimination half-life of 4 h, supporting twice weekly dosing. Of the six soluble angiogenic molecules assessed, only E-selectin increased significantly from baseline. Analysis of tumor microvessel density and gene expression was not informative due to intrapatient tumor heterogeneity. Although several patients with evaluable tumor biopsy pairs did reveal posttreatment increases in tumor and endothelial cell apoptosis, these results did not reach statistical significance due to the aforementioned heterogeneity., Conclusions: Cilengitide is a well-tolerated antiangiogenic agent. The biomarkers chosen in this study underscore the difficulty in assessing the biological activity of antiangiogenic agents in the absence of validated biological assays.
- Published
- 2007
- Full Text
- View/download PDF