7 results on '"Craddock, Nicholas"'
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2. Contributors
- Author
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Ackerman, Michael J., primary, Ahmed, Minhaz Uddin, additional, Ahn, Sun Hee, additional, Allingham, R. Rand, additional, Alsarraj, Jude, additional, Anderson, Matthew L., additional, Annex, Brian H., additional, Augustine, Christina K., additional, Baranzini, Sergio E., additional, Barnes, Peter J., additional, Beasley, Georgia M., additional, Becker, Richard C., additional, Benjamin, Ivor J., additional, Benson, D. Woodrow, additional, Bentzon, Jacob Fog, additional, Bernard, Philip S., additional, Bertram, Lars, additional, Beskow, Laura M., additional, Bondy, Brigitta, additional, Bos, J. Martijn, additional, Boulting, Gabriella L., additional, Brody, Jerome S., additional, Brown, April S., additional, Buetow, Kenneth H., additional, Bullinger, Lars, additional, Butte, Atul J., additional, Carey, David J., additional, Carlson, George, additional, Chen, David, additional, Chahrour, Maria, additional, Chiocca, E. Antonio, additional, Cho, Alex H., additional, Compton, Carolyn, additional, Cook-Deegan, Robert, additional, Craddock, Nicholas, additional, Coulter, Michael, additional, Damani, Samir B., additional, Danik, Jacqueline S., additional, Dave, Sandeep, additional, Dedrick, Russell, additional, DeLeo, Frank R., additional, Diamandis, Eleftherios P., additional, Dokun, Ayotunde O., additional, Downing, Gregory J., additional, Eck, Stephen L., additional, Edelman, Lucas B., additional, Eggan, Kevin C., additional, Falk, Erling, additional, Faruki, Hawazin, additional, Feng, Junjie, additional, Festen, Eleanora Anna Margaretha, additional, Florez, Jose C., additional, Fowler, Vance G., additional, Freedman, Jennifer A., additional, Freeze, Hudson H., additional, Fröhling, Stefan, additional, Galas, David J., additional, Gerhard, Glenn S., additional, Geschwind, Daniel H., additional, van Kessel, Ad Geurts, additional, Giffin, Robert B., additional, Ginsburg, Geoffrey S., additional, Goodall, Megan, additional, Govender, Praveen, additional, Green, Robert C., additional, Gunter, Chris, additional, Gwinn, Marta, additional, Haga, Susanne B., additional, Heath, James R., additional, Hegele, Robert A., additional, Holton, John, additional, Hood, Leroy, additional, Hunter, Kent W., additional, Hwang, Daehee, additional, Javitt, Gail, additional, Jefferson, Gina, additional, John, Sam, additional, Johnson, Keith J., additional, Johnson, Toby, additional, Joy, Tisha R., additional, Kathiresan, Sekar, additional, Kathuria, Hasmeena, additional, Katwal, Arabindra B., additional, Kawamoto, Kensaku, additional, Kelly, Andrea, additional, Khoury, Muin J., additional, Kim, Jin Woo, additional, Kingsmore, Stephen F., additional, Klingler, Tod, additional, Kobayashi, Scott D., additional, Kohane, Isaac S., additional, Kraus, Virginia Byers, additional, Kuiper, Roland P., additional, Lai-Goldman, Myla, additional, Lamb, Neil E., additional, Lambova, Sevdalina Nikolova, additional, Lanktree, Matthew B., additional, Lawler, Sean E., additional, Ledbetter, David H., additional, Lee, Charles, additional, Lee, Inyoul, additional, Le Roch, Karine G., additional, Levy, Samuel, additional, Limou, Sophie, additional, Liu, Wennuan, additional, Liu, Yutao, additional, London, Barry, additional, MacKeigan, Jeffrey P., additional, Mardis, Elaine R., additional, Marquez, Hector, additional, Marra, Marco, additional, Martin, Christa Lese, additional, Martin, Lisa J., additional, McCarroll, Steven A., additional, McHutchison, John, additional, McLeod, Howard L., additional, Mejías, Asunción, additional, Meltzer, Eric B., additional, Moody, M. Anthony, additional, Morin, Ryan D., additional, Moseley, M. Arthur, additional, Mountain, Joanna L., additional, Müller-Ladner, Ulf, additional, Munroe, Patricia B., additional, Ng, Bobby G., additional, Noble, Paul W., additional, O’Donovan, Michael C., additional, Odunsi, Kunle, additional, Omenn, Gilbert S., additional, Ommen, Steve R., additional, Orlando, Lori A., additional, Osterhaus, Albert D.M.E., additional, Owen, Michael J., additional, Parikshak, Neelroop N., additional, Patel, Keyur, additional, Pavlou, Maria P., additional, Paynter, Nina P., additional, Pejovic, Tanja, additional, Pham, Michael X., additional, Plenge, Robert M., additional, Podgoreanu, Mihai V., additional, Ponts, Nadia, additional, Price, Nathan D., additional, Quinn, Bruce, additional, Quintana, Francisco J., additional, Rader, Daniel J., additional, Ramilo, Octavio, additional, Rehm, Heidi L., additional, Rhodes, Benjamin, additional, Ridker, Paul M., additional, Riggs, Erin Rooney, additional, Ross, Jeffrey S., additional, Rubinstein, Wendy S., additional, Saunders, Carol J., additional, Scott, Joan, additional, Shackel, Nicholas A., additional, Shah, Svati H., additional, Simon, Richard, additional, Sisodiya, Sanjay M., additional, Smits, Saskia L., additional, Stamatoyannopoulos, John A., additional, Steele, Glenn D., additional, Steele, Mark P., additional, Stewart, Tessandra, additional, Thomas, Giovana R., additional, Topol, Eric J., additional, Tunis, Sean R., additional, Turner, Aubrey R., additional, Tyler, Douglas S., additional, Veenstra, David L., additional, Venkatachalam, Ramprasath, additional, Voora, Deepak, additional, Vyse, Timothy J., additional, Walsh, Christopher A., additional, Walsh, Katherine, additional, Wang, Hao, additional, Wang, Jun, additional, Weersma, Rinse K., additional, Weiner, Howard L., additional, Weiss, Scott T., additional, Wester, C. William, additional, Wholley, David N., additional, Wiggs, Janey L., additional, Wijmenga, Cisca, additional, Willard, Huntington F., additional, Williams, Hywel J., additional, Williams, Marc S., additional, Winkler, Cheryl A., additional, Woodcock, Janet, additional, Woods, Christopher W., additional, Wu, Pae C., additional, Xu, Jianfeng, additional, Yee, James, additional, Yoo, Hyuntae, additional, Yu, Timothy, additional, Zhang, Jing, additional, and Zhang, Yurong, additional
- Published
- 2013
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3. Current status of genetics of bipolar disorder
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Craddock, Nicholas John and Craddock, Nicholas John
4. Current status of molecular genetics of schizophrenia and bipolar disorder
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Craddock, Nicholas John and Craddock, Nicholas John
5. Specificity of polygenic signatures across symptom dimensions in bipolar disorder: an analysis of UK Bipolar Disorder Research Network data.
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Allardyce J, Cardno AG, Gordon-Smith K, Jones L, Di Florio A, Walters JTR, Holmans PA, Craddock NJ, Jones I, Owen MJ, Escott-Price V, and O'Donovan MC
- Subjects
- Humans, Male, Female, Middle Aged, Mania, United Kingdom, Multifactorial Inheritance genetics, Genetic Predisposition to Disease genetics, Bipolar Disorder psychology, Depressive Disorder, Major diagnosis, Depressive Disorder, Major genetics, Psychotic Disorders diagnosis
- Abstract
Background: Current definitions and clinical heterogeneity in bipolar disorder are major concerns as they obstruct aetiological research and impede drug development. Therefore, stratification of bipolar disorder is a high priority. To inform stratification, our analysis aimed to examine the patterns and relationships between polygenic liability for bipolar disorder, major depressive disorder (MDD), and schizophrenia with multidimensional symptom representations of bipolar disorder., Methods: In this analysis, data from the UK Bipolar Disorder Research Network (BDRN) were assessed with the Operational Checklist for Psychotic Disorders. Individuals with bipolar disorder as defined in DSM-IV, of European ancestry (self-reported), aged 18 years or older at time of interview, living in the UK, and registered with the BDRN were eligible for inclusion. Psychopathological variables obtained via interview by trained research psychologists or psychiatrists and psychiatric case notes were used to identify statistically distinct symptom dimensions, calibrated with exploratory factor analysis and validated with confirmatory factor analysis (CFA). CFA was extended to include three polygenic risk scores (PRSs) indexing liability for bipolar disorder, MDD, and schizophrenia in a multiple indicator multiple cause (MIMIC) structural equation model to estimate PRS relationships with symptom dimensions., Findings: Of 4198 individuals potentially eligible for inclusion, 4148 (2804 [67·6%] female individuals and 1344 [32·4%] male individuals) with a mean age at interview of 45 years (SD 12·03) were available for analysis. Three reliable dimensions (mania, depression, and psychosis) were identified. The MIMIC model fitted the data well (root mean square error of approximation 0·021, 90% CI 0·019-0·023; comparative fit index 0·99) and suggests statistically distinct symptom dimensions also have distinct polygenic profiles. The PRS for MDD was strongly associated with the depression dimension (standardised β 0·125, 95% CI 0·080-0·171) and the PRS for schizophrenia was strongly associated with the psychosis dimension (0·108, 0·082-0·175). For the mania dimension, the PRS for bipolar disorder was weakly associated (0·050, 0·002-0·097)., Interpretation: Our findings support the hypothesis that genetic heterogeneity underpins clinical heterogeneity, suggesting that different symptom dimensions within bipolar disorder have partly distinct causes. Furthermore, our results suggest that a specific symptom dimension has a similar cause regardless of the primary psychiatric diagnosis, supporting the use of symptom dimensions in precision psychiatry., Funding: Wellcome Trust and UK Medical Research Council., Competing Interests: Declaration of interests We declare no competing interests., (Crown Copyright © 2023 Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license.)
- Published
- 2023
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6. Dissecting the Shared Genetic Architecture of Suicide Attempt, Psychiatric Disorders, and Known Risk Factors.
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Mullins N, Kang J, Campos AI, Coleman JRI, Edwards AC, Galfalvy H, Levey DF, Lori A, Shabalin A, Starnawska A, Su MH, Watson HJ, Adams M, Awasthi S, Gandal M, Hafferty JD, Hishimoto A, Kim M, Okazaki S, Otsuka I, Ripke S, Ware EB, Bergen AW, Berrettini WH, Bohus M, Brandt H, Chang X, Chen WJ, Chen HC, Crawford S, Crow S, DiBlasi E, Duriez P, Fernández-Aranda F, Fichter MM, Gallinger S, Glatt SJ, Gorwood P, Guo Y, Hakonarson H, Halmi KA, Hwu HG, Jain S, Jamain S, Jiménez-Murcia S, Johnson C, Kaplan AS, Kaye WH, Keel PK, Kennedy JL, Klump KL, Li D, Liao SC, Lieb K, Lilenfeld L, Liu CM, Magistretti PJ, Marshall CR, Mitchell JE, Monson ET, Myers RM, Pinto D, Powers A, Ramoz N, Roepke S, Rozanov V, Scherer SW, Schmahl C, Sokolowski M, Strober M, Thornton LM, Treasure J, Tsuang MT, Witt SH, Woodside DB, Yilmaz Z, Zillich L, Adolfsson R, Agartz I, Air TM, Alda M, Alfredsson L, Andreassen OA, Anjorin A, Appadurai V, Soler Artigas M, Van der Auwera S, Azevedo MH, Bass N, Bau CHD, Baune BT, Bellivier F, Berger K, Biernacka JM, Bigdeli TB, Binder EB, Boehnke M, Boks MP, Bosch R, Braff DL, Bryant R, Budde M, Byrne EM, Cahn W, Casas M, Castelao E, Cervilla JA, Chaumette B, Cichon S, Corvin A, Craddock N, Craig D, Degenhardt F, Djurovic S, Edenberg HJ, Fanous AH, Foo JC, Forstner AJ, Frye M, Fullerton JM, Gatt JM, Gejman PV, Giegling I, Grabe HJ, Green MJ, Grevet EH, Grigoroiu-Serbanescu M, Gutierrez B, Guzman-Parra J, Hamilton SP, Hamshere ML, Hartmann A, Hauser J, Heilmann-Heimbach S, Hoffmann P, Ising M, Jones I, Jones LA, Jonsson L, Kahn RS, Kelsoe JR, Kendler KS, Kloiber S, Koenen KC, Kogevinas M, Konte B, Krebs MO, Landén M, Lawrence J, Leboyer M, Lee PH, Levinson DF, Liao C, Lissowska J, Lucae S, Mayoral F, McElroy SL, McGrath P, McGuffin P, McQuillin A, Medland SE, Mehta D, Melle I, Milaneschi Y, Mitchell PB, Molina E, Morken G, Mortensen PB, Müller-Myhsok B, Nievergelt C, Nimgaonkar V, Nöthen MM, O'Donovan MC, Ophoff RA, Owen MJ, Pato C, Pato MT, Penninx BWJH, Pimm J, Pistis G, Potash JB, Power RA, Preisig M, Quested D, Ramos-Quiroga JA, Reif A, Ribasés M, Richarte V, Rietschel M, Rivera M, Roberts A, Roberts G, Rouleau GA, Rovaris DL, Rujescu D, Sánchez-Mora C, Sanders AR, Schofield PR, Schulze TG, Scott LJ, Serretti A, Shi J, Shyn SI, Sirignano L, Sklar P, Smeland OB, Smoller JW, Sonuga-Barke EJS, Spalletta G, Strauss JS, Świątkowska B, Trzaskowski M, Turecki G, Vilar-Ribó L, Vincent JB, Völzke H, Walters JTR, Shannon Weickert C, Weickert TW, Weissman MM, Williams LM, Wray NR, Zai CC, Ashley-Koch AE, Beckham JC, Hauser ER, Hauser MA, Kimbrel NA, Lindquist JH, McMahon B, Oslin DW, Qin X, Agerbo E, Børglum AD, Breen G, Erlangsen A, Esko T, Gelernter J, Hougaard DM, Kessler RC, Kranzler HR, Li QS, Martin NG, McIntosh AM, Mors O, Nordentoft M, Olsen CM, Porteous D, Ursano RJ, Wasserman D, Werge T, Whiteman DC, Bulik CM, Coon H, Demontis D, Docherty AR, Kuo PH, Lewis CM, Mann JJ, Rentería ME, Smith DJ, Stahl EA, Stein MB, Streit F, Willour V, and Ruderfer DM
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- Genome-Wide Association Study, Humans, Polymorphism, Single Nucleotide, Risk Factors, Suicide, Attempted, Depressive Disorder, Major genetics, Mental Disorders genetics
- Abstract
Background: Suicide is a leading cause of death worldwide, and nonfatal suicide attempts, which occur far more frequently, are a major source of disability and social and economic burden. Both have substantial genetic etiology, which is partially shared and partially distinct from that of related psychiatric disorders., Methods: We conducted a genome-wide association study (GWAS) of 29,782 suicide attempt (SA) cases and 519,961 controls in the International Suicide Genetics Consortium (ISGC). The GWAS of SA was conditioned on psychiatric disorders using GWAS summary statistics via multitrait-based conditional and joint analysis, to remove genetic effects on SA mediated by psychiatric disorders. We investigated the shared and divergent genetic architectures of SA, psychiatric disorders, and other known risk factors., Results: Two loci reached genome-wide significance for SA: the major histocompatibility complex and an intergenic locus on chromosome 7, the latter of which remained associated with SA after conditioning on psychiatric disorders and replicated in an independent cohort from the Million Veteran Program. This locus has been implicated in risk-taking behavior, smoking, and insomnia. SA showed strong genetic correlation with psychiatric disorders, particularly major depression, and also with smoking, pain, risk-taking behavior, sleep disturbances, lower educational attainment, reproductive traits, lower socioeconomic status, and poorer general health. After conditioning on psychiatric disorders, the genetic correlations between SA and psychiatric disorders decreased, whereas those with nonpsychiatric traits remained largely unchanged., Conclusions: Our results identify a risk locus that contributes more strongly to SA than other phenotypes and suggest a shared underlying biology between SA and known risk factors that is not mediated by psychiatric disorders., (Copyright © 2021 Society of Biological Psychiatry. All rights reserved.)
- Published
- 2022
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7. Mental health resilience in the adolescent offspring of parents with depression: a prospective longitudinal study.
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Collishaw S, Hammerton G, Mahedy L, Sellers R, Owen MJ, Craddock N, Thapar AK, Harold GT, Rice F, and Thapar A
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- Adolescent, Child of Impaired Parents statistics & numerical data, Female, Humans, Longitudinal Studies, Male, Prospective Studies, Child of Impaired Parents psychology, Depression, Resilience, Psychological
- Abstract
Background: Young people whose parents have depression have a greatly increased risk of developing a psychiatric disorder, but poor outcomes are not inevitable. Identification of the contributors to mental health resilience in young people at high familial risk is an internationally recognised priority. Our objectives were to identify protective factors that predict sustained good mental health in adolescents with a parent with depression and to test whether these contribute beyond what is explained by parent illness severity., Methods: The Early Prediction of Adolescent Depression study (EPAD) is a prospective longitudinal study of offspring of parents with recurrent depression. Parents with recurrent major depressive disorder, co-parents, and offspring (aged 9-17 years at baseline) were assessed three times over 4 years in a community setting. Offspring outcomes were operationalised as absence of mental health disorder, subthreshold symptoms, or suicidality on all three study occasions (sustained good mental health); and better than expected mental health (mood and behavioural symptoms at follow-up lower than predicted given severity of parental depression). Family, social, cognitive, and health behaviour predictor variables were assessed using interview and questionnaire measures., Findings: Between February and June, 2007, we screened 337 families at baseline, of which 331 were eligible. Of these, 262 completed the three assessments and were included in the data for sustained mental health. Adolescent mental health problems were common, but 53 (20%) of the 262 adolescents showed sustained good mental health. Index parent positive expressed emotion (odds ratio 1·91 [95% CI 1·31-2·79]; p=0·001), co-parent support (1·90 [1·38-2·62]; p<0·0001), good-quality social relationships (2·07 [1·35-3·18]; p=0·001), self-efficacy (1·49 [1·05-2·11]; p=0·03), and frequent exercise (2·96 [1·26-6·92]; p=0·01) were associated with sustained good mental health. Analyses accounting for parent depression severity were consistent, but frequent exercise only predicted better than expected mood-related mental health (β=-0·22; p=0·0004) not behavioural mental health, whereas index parents' expression of positive emotions predicted better than expected behavioural mental health (β=-0·16; p=0·01) not mood-related mental health. Multiple protective factors were required for offspring to be free of mental health problems (zero or one protective factor, 4% sustained good mental health; two protective factors, 10%; three protective factors, 13%, four protective factors, 38%; five protective factors, 48%)., Interpretation: Adolescent mental health problems are common, but not inevitable, even when parental depression is severe and recurrent. These findings suggest that prevention programmes will need to enhance multiple protective factors across different domains of functioning., Funding: Sir Jules Thorn Charitable Trust, Economic and Social Research Council., (Copyright © 2016 Collishaw et al. Open Access article distributed under the terms of CC BY. Published by Elsevier Ltd.. All rights reserved.)
- Published
- 2016
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