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Knee arthrodesis is an option in the setting of failed total knee arthroplasty. Dual-plate fixation is a described technique to obtain knee fusion in this scenario. Literature on the complications of knee arthrodesis with dual-plate constructs is limited. We present 3 cases who underwent dual-plate knee arthrodesis complicated by peri-implant femur fracture., (© 2019 Published by Elsevier Inc. on behalf of The American Association of Hip and Knee Surgeons.)

We investigated whether transcriptional inducers could enhance the expression of acetylcholinesterase (AChE) in cell lines to achieve protection against organophosphate (OP) poisoning. Trichostatin A (TSA), an inhibitor of histone deacetylase that de-condenses chromatin and increases the binding of transcription factors and mRNA synthesis, induced three- to four-fold extracellular and 8-10-fold intracellular AChE expression at the optimal dose of 165-333 nM in Neuro 2A cells. Pre-treatment with TSA protected against OP exposure. Thus, transcriptional inducers, such as TSA, up-regulate AChE, which then can scavenge the OP and protect the cells from OP-induced toxicity, and are potential novel ways to treat chemical warfare nerve agent (CWNA) exposure.

Purpose: To study the effects of transcleral cryotherapy and laser photocoagulation of anterior retina on ocular growth., Methods: Twenty-one rabbits underwent transcleral cryotherapy or indirect ophthalmoscopic laser photocoagulation of the anterior retina on one of their eyes between 2 and 8 weeks of age., Results: After the rabbits were killed between 3 and 6 months of age, treated rabbit eyes were found to be significantly smaller in axial length (P < 0.001), average equatorial diameter (P < 0.01), average corneal diameter (P < 0.05), and in total ocular volume (P < 0.01). The difference in eye size was not due to lowered intraocular pressure., Conclusions: The results demonstrate that these treatments slow growth of both the anterior and posterior segment of rabbit eyes.

Physiologic myopia occurs as the result of a correlation failure of refraction components in the normal eye. Pathologic myopia is caused by excessive axial elongation that primarily involves the ora-equatorial area and the posterior pole. Peripheral fundus changes and posterior staphyloma formation are ophthalmoscopic evidences of this process. Heredity is the basic determinant of ocular refraction, but numerous agents produce both temporary and permanent myopias.