1. Cytotoxic principles of Parquetina nigrescens (Afzel.) Bullock (Asclepiadaceae).
- Author
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Marks WH, Fong HH, Tin-Wa M, and Farnsworth NR
- Subjects
- Animals, Antineoplastic Agents therapeutic use, Cardiac Glycosides therapeutic use, Cymarine isolation & purification, Leukemia, Experimental drug therapy, Phytosterols isolation & purification, Plant Extracts isolation & purification, Plant Extracts therapeutic use, Sitosterols isolation & purification, Strophanthidin isolation & purification, Antineoplastic Agents isolation & purification, Cardiac Glycosides isolation & purification, Plants analysis
- Abstract
Systematic fractionation of the cytotoxic extracts of the roots of Parquetina nigrescens (Afzel.) Bullock (Asclepiadaceae) on silica gel column chromatography led to the isolation of three cardenolides: cymarin, strophanthidin, and a strophanthidin glycoside (XS-89). Also isolated during the investigation were beta-sitosterol-beta-D-glucoside, a mixture of alpha- and beta-amyrins, a mixture of alkanols, and a mixture of plant sterols.
- Published
- 1975
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