8 results on '"Dafu Zhang"'
Search Results
2. Behavior of magnesium impurity during carbochlorination of magnesium-bearing titanium slag in chloride media
- Author
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Liang Li, Fuxing Zhu, Pan Deng, Dafu Zhang, Yaoqiang Jia, Kaihua Li, Lingxin Kong, and Dachun Liu
- Subjects
Titanium slag ,Magnesium impurity ,Carbochlorination ,Chloride molten salts ,Mining engineering. Metallurgy ,TN1-997 - Abstract
In this study, the phase composition, morphology, and element distribution of Mg impurities in a low-grade titanium slag and in its chlorinated residue after carbochlorination were identified using XRD, SEM-EDS, and MLA. Most Mg impurities existed as anosovite, rutile, titanaugite, and Ti silicate phases before the carbochlorination process. The thermodynamic analysis revealed that the chlorination tendencies of Mg, Ti, Ca, Fe, and Mn oxides in the original titanium slag was much higher than those of Si and Al oxides in the temperature range of 700–850 °C. In addition, the binary phase diagram analysis indicates that the magnesium chloride (MgCl2) byproduct formed Na2MgCl4 eutectic salts in the NaCl-based salt bath. The carbochlorination experiments of the Mg-bearing titanium slag show that the chlorination ratio of magnesium oxide was above 93% under the suitable industrial conditions used for the extraction of titanium from Mg-bearing titanium slag. In addition, the formation of Na2MgCl4 eutectic salts after carbochlorination was confirmed, indicating that the negative effect of MgCl2 on the chlorination process was effectively eliminated. The Mg impurities in the chlorinated residue existed as titanaugite, quartz, chlorite, and rutile phases. Furthermore, we found that the carbochlorination of Mg-bearing titanium slag in chloride media effectively improved the comprehensive utilization efficiency of the Mg-bearing titanium slag. We believe that the proposed carbochlorination mechanism of the Mg-bearing titanium slag will provide thorough understanding and useful guidance on the practical industrial application of Mg-bearing titanium slag.
- Published
- 2021
- Full Text
- View/download PDF
3. Electrochemical synthesis of Ti–Al–V alloy by chlorination of Ti2O3 and V2O3 in AlCl3-containing molten chloride salt
- Author
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Fuxing Zhu, Liang Li, Wenchen Song, Dafu Zhang, Shangrun Ma, and Kehui Qiu
- Subjects
Ti–Al–V alloy ,Electrochemical co-deposition ,Molten chloride salt ,Ti2O3 ,V2O3 ,Mining engineering. Metallurgy ,TN1-997 - Abstract
The current study proposes a novel method of preparing Ti–Al–V alloy by electrochemical co-deposition by adding Ti2O3 and V2O3 into the molten salt system. The influence of chlorination of Ti2O3 and V2O3 in KCl–LiCl–MgCl2–AlCl3 melt was studied by inductively-coupled plasma emission spectrometer (ICP-AES) and X-ray diffractometer (XRD). The results revealed that the optimal chlorination temperature ranged from 600 °C to 700 °C and the main chlorination products were TiCl3, VCl3, and Al2O3 byproduct. The electrochemical behavior of Ti3+, V3+ and Al3+ in a molten AlCl3-containing chloride salt was investigated by cyclic voltammetry. The stepwise reduction in the cathode could be given as: V3+→V2+, Ti3+→Ti2+, V2+→V, Ti2+→Ti, Ti2+/V2+/Al3+→Ti–Al–V alloy. The electrolytic products were also characterized by XRD and scanning electron microscopy (SEM), equipped with energy dispersive spectroscopy (EDS). The results demonstrated that, as metallic Al was used as an anode, a dendritic Al3Ti alloy and Al sheet were obtained after the addition of Ti2O3 into the KCl–LiCl–MgCl2–AlCl3 melt. However, the presence of both Ti2O3 and V2O3 resulted in fishbone-like Al3Ti, Al3Ti0.8V0.2 and Al3Ti0.666V0.333 alloys, as well as dense granules of metallic Al.
- Published
- 2021
- Full Text
- View/download PDF
4. Trajectories of Perioperative Serum Tumor Markers and Colorectal Cancer Outcomes: A Retrospective, Multicenter Longitudinal Cohort Study
- Author
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Chunxia Li, Dafu Zhang, Xiaolin Pang, Hongjiang Pu, Ming Lei, Bingbing Fan, Jiali Lv, Dingyun You, Zhenhui Li, and Tao Zhang
- Subjects
Colorectal cancer ,Serum tumor markers ,Trajectories ,Overall survival ,Recurrence-free survival ,Medicine ,Medicine (General) ,R5-920 - Abstract
Background: The dynamic monitoring of perioperative carcinoembryonic antigen (CEA) is recommended by current colorectal cancer (CRC) guidelines, while the benefits of additional measurements of carbohydrate antigen 19-9 (CA19-9) and carbohydrate antigen 125 (CA125) have remained controversial. Methods: This retrospective longitudinal cohort included 3539 CRC patients who underwent curative resection. Distinct trajectory groups were identified by the latent class growth mixed model. Patients were grouped into subgroups jointly by CEA, CA19-9, and CA125 according to preoperative levels and longitudinal trajectories, respectively. The end points were overall survival (OS) and recurrence-free survival (RFS). Findings: Three distinct trajectory groups were characterized for serum CEA, CA19-9, and CA125: low-stable, early-rising, and later-rising. Jointly, patients were grouped into six preoperative (trajectory) joint groups. Compared with the three-low group, the adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) associated with death were 1.87 (1.29-2.70), 3.82 (2.37-6.17), 1.87 (0.97-3.61), 2.81 (1.93-4.11), and 4.99 (2.80-8.86) for the CEA-high, CA19-9-high, CA125-high, two-high, and three-high group, respectively. And compared with the three-stable trajectory group, the corresponding HRs (95% CIs) were 1.59 (1.10-2.30), 1.55 (0.77-3.10), 6.25 (4.02-9.70), 4.05 (2.73-6.02), and 12.40 (5.77-26.70) for the five rising trajectory groups, respectively. Similar associations between joint groups and RFS were observed. Notably, the trajectory joint group still had prognostic significance after adjusting for preoperative levels. The CA19-9-high group (HR: 3.82, 95% CI: 2.37-6.17) was associated with higher risk of death than the two-high group (HR: 2.81, 95% CI: 1.93-4.11). Likewise, for the CA125-rising trajectory group and two-rising trajectory group, the HRs (95% CIs) were 6.13 (3.75-10.00) and 3.99 (2.63-6.05) for death, and 3.08 (2.07-4.58) and 2.10 (1.52-2.90) for recurrence. Interpretation: In addition to CEA, the dynamic measurements of CA19-9 and CA125 are recommended to monitor the prognosis of CRC patients. Funding: National Natural Science Foundation of China [81973147, 82001986, 81960592, 82073569, 81660545].
- Published
- 2021
- Full Text
- View/download PDF
5. Deep learning radiomics-based prediction of distant metastasis in patients with locally advanced rectal cancer after neoadjuvant chemoradiotherapy: A multicentre study
- Author
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Xiangyu Liu, Dafu Zhang, Zhenyu Liu, Zhenhui Li, Peiyi Xie, Kai Sun, Wei Wei, Weixing Dai, Zhenchao Tang, Yingying Ding, Guoxiang Cai, Tong Tong, Xiaochun Meng, and Jie Tian
- Subjects
Locally advanced rectal cancer ,Distant metastasis ,Neoadjuvant chemoradiotherapy ,Deep learning radiomics ,Magnetic resonance imaging ,Medicine ,Medicine (General) ,R5-920 - Abstract
Background: Accurate predictions of distant metastasis (DM) in locally advanced rectal cancer (LARC) patients receiving neoadjuvant chemoradiotherapy (nCRT) are helpful in developing appropriate treatment plans. This study aimed to perform DM prediction through deep learning radiomics. Methods: We retrospectively sampled 235 patients receiving nCRT with the minimum 36 months’ postoperative follow-up from three hospitals. Through transfer learning, a deep learning radiomic signature (DLRS) based on multiparametric magnetic resonance imaging (MRI) was constructed. A nomogram was established integrating deep MRI information and clinicopathologic factors for better prediction. Harrell's concordance index (C-index) and time-dependent receiver operating characteristic (ROC) were used as performance metrics. Furthermore, the risk of DM in patients with different response to nCRT was evaluated with the nomogram. Findings: DLRS performed well in DM prediction, with a C-index of 0·747 and an area under curve (AUC) at three years of 0·894 in the validation cohort. The performance of nomogram was better, with a C-index of 0·775. In addition, the nomogram could stratify patients with different responses to nCRT into high- and low-risk groups of DM (P < 0·05). Interpretation: MRI-based deep learning radiomics had potential in predicting the DM of LARC patients receiving nCRT and could help evaluate the risk of DM in patients who have different responses to nCRT. Funding: The funding bodies that contributed to this study are listed in the Acknowledgements section.
- Published
- 2021
- Full Text
- View/download PDF
6. Electrochemical synthesis of Ti–Al–V alloy by chlorination of Ti2O3 and V2O3 in AlCl3-containing molten chloride salt
- Author
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Kehui Qiu, Liang Li, Dafu Zhang, Zhu Fuxing, Shangrun Ma, and Wenchen Song
- Subjects
Materials science ,Scanning electron microscope ,Alloy ,Inorganic chemistry ,Energy-dispersive X-ray spectroscopy ,Molten chloride salt ,02 engineering and technology ,engineering.material ,Electrochemistry ,01 natural sciences ,law.invention ,Biomaterials ,V2O3 ,law ,0103 physical sciences ,Electrochemical co-deposition ,Molten salt ,Diffractometer ,010302 applied physics ,Mining engineering. Metallurgy ,Ti2O3 ,Metals and Alloys ,TN1-997 ,021001 nanoscience & nanotechnology ,Cathode ,Surfaces, Coatings and Films ,Ti–Al–V alloy ,Ceramics and Composites ,engineering ,Cyclic voltammetry ,0210 nano-technology - Abstract
The current study proposes a novel method of preparing Ti–Al–V alloy by electrochemical co-deposition by adding Ti2O3 and V2O3 into the molten salt system. The influence of chlorination of Ti2O3 and V2O3 in KCl–LiCl–MgCl2–AlCl3 melt was studied by inductively-coupled plasma emission spectrometer (ICP-AES) and X-ray diffractometer (XRD). The results revealed that the optimal chlorination temperature ranged from 600 °C to 700 °C and the main chlorination products were TiCl3, VCl3, and Al2O3 byproduct. The electrochemical behavior of Ti3+, V3+ and Al3+ in a molten AlCl3-containing chloride salt was investigated by cyclic voltammetry. The stepwise reduction in the cathode could be given as: V3+→V2+, Ti3+→Ti2+, V2+→V, Ti2+→Ti, Ti2+/V2+/Al3+→Ti–Al–V alloy. The electrolytic products were also characterized by XRD and scanning electron microscopy (SEM), equipped with energy dispersive spectroscopy (EDS). The results demonstrated that, as metallic Al was used as an anode, a dendritic Al3Ti alloy and Al sheet were obtained after the addition of Ti2O3 into the KCl–LiCl–MgCl2–AlCl3 melt. However, the presence of both Ti2O3 and V2O3 resulted in fishbone-like Al3Ti, Al3Ti0.8V0.2 and Al3Ti0.666V0.333 alloys, as well as dense granules of metallic Al.
- Published
- 2021
7. Trajectories of Perioperative Serum Tumor Markers and Colorectal Cancer Outcomes: A Retrospective, Multicenter Longitudinal Cohort Study
- Author
-
Jiali Lv, Tao Zhang, Zhenhui Li, Dafu Zhang, Hongjiang Pu, Dingyun You, Chunxia Li, Bingbing Fan, Ming Lei, and Xiaolin Pang
- Subjects
Male ,Medicine (General) ,Research paper ,Colorectal cancer ,LCGMM, latent class growth mixed model ,Trajectories ,Carcinoembryonic antigen ,Overall survival ,Longitudinal Studies ,Longitudinal cohort ,biology ,Hazard ratio ,General Medicine ,Prognosis ,RFS, recurrence-free survival ,Treatment Outcome ,CRC, colorectal cancer ,Medicine ,Female ,CA19-9 ,Colorectal Neoplasms ,medicine.medical_specialty ,CA125, carbohydrate antigen 125 ,GPI-Linked Proteins ,Perioperative Care ,General Biochemistry, Genetics and Molecular Biology ,OS, overall survival ,R5-920 ,CA19-9, carbohydrate antigen 19-9 ,Internal medicine ,Biomarkers, Tumor ,medicine ,Humans ,Antigens, Tumor-Associated, Carbohydrate ,Serum tumor markers ,Retrospective Studies ,business.industry ,Membrane Proteins ,Perioperative ,medicine.disease ,Recurrence-free survival ,Survival Analysis ,HR, hazard ratio ,Confidence interval ,Carcinoembryonic Antigen ,CI, confidence interval ,CA-125 Antigen ,biology.protein ,CEA, carcinoembryonic antigen ,business - Abstract
Background The dynamic monitoring of perioperative carcinoembryonic antigen (CEA) is recommended by current colorectal cancer (CRC) guidelines, while the benefits of additional measurements of carbohydrate antigen 19-9 (CA19-9) and carbohydrate antigen 125 (CA125) have remained controversial. Methods This retrospective longitudinal cohort included 3539 CRC patients who underwent curative resection. Distinct trajectory groups were identified by the latent class growth mixed model. Patients were grouped into subgroups jointly by CEA, CA19-9, and CA125 according to preoperative levels and longitudinal trajectories, respectively. The end points were overall survival (OS) and recurrence-free survival (RFS). Findings Three distinct trajectory groups were characterized for serum CEA, CA19-9, and CA125: low-stable, early-rising, and later-rising. Jointly, patients were grouped into six preoperative (trajectory) joint groups. Compared with the three-low group, the adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) associated with death were 1.87 (1.29-2.70), 3.82 (2.37-6.17), 1.87 (0.97-3.61), 2.81 (1.93-4.11), and 4.99 (2.80-8.86) for the CEA-high, CA19-9-high, CA125-high, two-high, and three-high group, respectively. And compared with the three-stable trajectory group, the corresponding HRs (95% CIs) were 1.59 (1.10-2.30), 1.55 (0.77-3.10), 6.25 (4.02-9.70), 4.05 (2.73-6.02), and 12.40 (5.77-26.70) for the five rising trajectory groups, respectively. Similar associations between joint groups and RFS were observed. Notably, the trajectory joint group still had prognostic significance after adjusting for preoperative levels. The CA19-9-high group (HR: 3.82, 95% CI: 2.37-6.17) was associated with higher risk of death than the two-high group (HR: 2.81, 95% CI: 1.93-4.11). Likewise, for the CA125-rising trajectory group and two-rising trajectory group, the HRs (95% CIs) were 6.13 (3.75-10.00) and 3.99 (2.63-6.05) for death, and 3.08 (2.07-4.58) and 2.10 (1.52-2.90) for recurrence. Interpretation In addition to CEA, the dynamic measurements of CA19-9 and CA125 are recommended to monitor the prognosis of CRC patients. Funding National Natural Science Foundation of China [81973147, 82001986, 81960592, 82073569, 81660545].
- Published
- 2021
8. Deep learning radiomics-based prediction of distant metastasis in patients with locally advanced rectal cancer after neoadjuvant chemoradiotherapy: A multicentre study
- Author
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Jie Tian, Zhenhui Li, Xiangyu Liu, Tong Tong, Peiyi Xie, Xiaochun Meng, Dafu Zhang, Wei Wei, Kai Sun, Zhenyu Liu, Yingying Ding, Zhenchao Tang, Guoxiang Cai, and Weixing Dai
- Subjects
0301 basic medicine ,Male ,medicine.medical_specialty ,Medicine (General) ,Research paper ,Colorectal cancer ,Locally advanced ,General Biochemistry, Genetics and Molecular Biology ,03 medical and health sciences ,0302 clinical medicine ,R5-920 ,Deep Learning ,Image Interpretation, Computer-Assisted ,Medicine ,Humans ,Neoplasm Metastasis ,Locally advanced rectal cancer ,Aged ,medicine.diagnostic_test ,Receiver operating characteristic ,business.industry ,Rectal Neoplasms ,Deep learning ,Distant metastasis ,Magnetic resonance imaging ,General Medicine ,Deep learning radiomics ,Nomogram ,Middle Aged ,medicine.disease ,Magnetic Resonance Imaging ,Neoadjuvant Therapy ,Neoadjuvant chemoradiotherapy ,Nomograms ,030104 developmental biology ,030220 oncology & carcinogenesis ,Female ,Artificial intelligence ,Radiology ,business - Abstract
Background Accurate predictions of distant metastasis (DM) in locally advanced rectal cancer (LARC) patients receiving neoadjuvant chemoradiotherapy (nCRT) are helpful in developing appropriate treatment plans. This study aimed to perform DM prediction through deep learning radiomics. Methods We retrospectively sampled 235 patients receiving nCRT with the minimum 36 months’ postoperative follow-up from three hospitals. Through transfer learning, a deep learning radiomic signature (DLRS) based on multiparametric magnetic resonance imaging (MRI) was constructed. A nomogram was established integrating deep MRI information and clinicopathologic factors for better prediction. Harrell's concordance index (C-index) and time-dependent receiver operating characteristic (ROC) were used as performance metrics. Furthermore, the risk of DM in patients with different response to nCRT was evaluated with the nomogram. Findings DLRS performed well in DM prediction, with a C-index of 0·747 and an area under curve (AUC) at three years of 0·894 in the validation cohort. The performance of nomogram was better, with a C-index of 0·775. In addition, the nomogram could stratify patients with different responses to nCRT into high- and low-risk groups of DM (P Interpretation MRI-based deep learning radiomics had potential in predicting the DM of LARC patients receiving nCRT and could help evaluate the risk of DM in patients who have different responses to nCRT. Funding The funding bodies that contributed to this study are listed in the Acknowledgements section.
- Published
- 2021
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