220 results on '"Davies, Mark"'
Search Results
2. List of Contributors
- Author
-
Abi-Aad, Karl, primary, Abu-Halimah, Shadi, additional, AbuRahma, Ali F., additional, Acharya, Yogesh, additional, Anain, Paul, additional, Aridi, Hanaa Dakour, additional, Asciutto, Giuseppe, additional, Atwal, Gursant S., additional, Avgerinos, Efthymios D., additional, Ayad, Micheal T., additional, Beecher, Jeffrey S., additional, Bendok, Bernard R., additional, Brinster, Clayton J., additional, Cantos, Andrew J., additional, Carpenter, Jeffrey P., additional, Chaer, Rabih A., additional, Chang, Jason, additional, Cherr, Gregory S., additional, Cheun, Tracy J., additional, Chuter, Timothy A.M., additional, Curl, Richard, additional, Dake, Michael D., additional, Darling, R. Clement, additional, Davies, Mark G., additional, Doshi, Dolly Thakkar, additional, Dosluoglu, Hasan H., additional, D’Souza, Ashwini, additional, Dryjski, Maciej L., additional, Edwards, Jeffrey B., additional, Eijkenboom, Quirine L., additional, Faggioli, Gianluca, additional, Farber, Mark A., additional, Farnsworth, Joseph B., additional, Fennell, Vernard S., additional, Feyko, Jared T., additional, Flohr, Tanya R., additional, Fontenot, Danielle, additional, Gallitto, Enrico, additional, Gargiulo, Mauro, additional, Gillespie, David L., additional, Go, Catherine C., additional, Hall, Michael R., additional, Harris, Linda M., additional, Hnath, Jeffrey C., additional, Hynes, Niamh, additional, Illig, Karl A., additional, Jayakumar, Lalithapriya, additional, Kapadia, Samir R., additional, Kärkkäinen, Jussi M., additional, Kasprzak, Piotr M., additional, Kavanagh, Edel P., additional, Khan, Sikandar Z., additional, Kostun, Zachary W., additional, Koudoumas, Dimitrios, additional, Krishna, Chandan, additional, Krishnaswamy, Amar, additional, Lal, Brajesh K., additional, Lehrman, Evan D., additional, Levy, Elad I., additional, Liang, Patric, additional, Lim, Jaims, additional, Malas, Mahmoud B., additional, Marone, Luke, additional, McKinsey, James F., additional, McMackin, Katherine K., additional, Mehta, Manish, additional, Meier, George H., additional, Milner, Ross, additional, Montross, Brittany C., additional, Morrison, John F., additional, Mouawad, Nicolas J., additional, Mousa, Albeir Y., additional, Oderich, Gustavo S., additional, O’Donnell, Thomas F.X., additional, Oikonomou, Kyriakos, additional, Ou, Christine, additional, Panneton, Jean M., additional, Patra, Devi P., additional, Pfister, Karin, additional, Pini, Rodolfo, additional, Powell, Richard J., additional, Raffetto, Joseph D., additional, Ramdon, Andre R., additional, Rathore, Animesh, additional, Ravin, Reid, additional, Reed, Amy B., additional, Reilly, Brendon, additional, Resch, Timothy, additional, Rhee, Robert, additional, Rivero, Mariel, additional, Sattur, Mithun G., additional, Schermerhorn, Marc L., additional, Shakir, Hakeem J., additional, Shames, Murray L., additional, Shih, Michael, additional, Shivapour, Daniel M., additional, Siddiqui, Adnan H., additional, Snyder, Kenneth V., additional, Stella, Andrea, additional, Stoner, Michael C., additional, Sultan, Sherif, additional, Sywak, Michael, additional, Tallarita, Tiziano, additional, Tan, Tze-Woei, additional, Tenorio, Emanuel R., additional, TerBush, Matthew J., additional, Tian, Fucheng, additional, Tran, Kenneth, additional, Ullery, Brant W., additional, Vakharia, Kunal, additional, Waldman, David L., additional, Wang, Sophie, additional, Weintraub, Joshua L., additional, Welz, Matthew E., additional, Woo, Karen, additional, Wooster, Mathew, additional, Wu, Winona, additional, Yacoub, Michael, additional, Zacharias, Nikolaos, additional, and Zhang, Wayne W., additional
- Published
- 2022
- Full Text
- View/download PDF
3. Cardiac Safety Pharmacology Modeling
- Author
-
Davies, Mark R., primary
- Published
- 2021
- Full Text
- View/download PDF
4. Compassion fatigue & burnout
- Author
-
Russo, Chuck, primary, Aukhojee, Prashant, additional, Tuttle, Brooke McQuerrey, additional, Johnson, Olivia, additional, Davies, Mark, additional, Chopko, Brian A., additional, and Papazoglou, Konstantinos, additional
- Published
- 2020
- Full Text
- View/download PDF
5. Contributors
- Author
-
Aukhojee, Prashant, primary, Blumberg, Daniel M., additional, Burke, Kimberly C., additional, Chopko, Brian A., additional, Couperthwaite, Lisa M.Z., additional, Creighton, Sarah, additional, Davies, Mark, additional, Eagle, Andrew L., additional, Faulkner, Breanne, additional, Fuss, Samantha, additional, Johnson, Olivia, additional, Kamkar, Katy, additional, Kaye, Chuck, additional, Keesee, Tracie, additional, Kwiatkowski, Christine C., additional, Manning, Claire E., additional, Milliard, Detective Beth, additional, Papazoglou, Konstantinos, additional, Robison, Alfred J., additional, Rubim, Felipe, additional, Rubim, Lucas, additional, Russo, Chuck, additional, Schlosser, Mike, additional, Thornton, Alex R., additional, Tuttle, Brooke McQuerrey, additional, and Violanti, John M., additional
- Published
- 2020
- Full Text
- View/download PDF
6. Big Data in Drug Discovery
- Author
-
Brown, Nathan, primary, Cambruzzi, Jean, additional, Cox, Peter J., additional, Davies, Mark, additional, Dunbar, James, additional, Plumbley, Dean, additional, Sellwood, Matthew A., additional, Sim, Aaron, additional, Williams-Jones, Bryn I., additional, Zwierzyna, Magdalena, additional, and Sheppard, David W., additional
- Published
- 2018
- Full Text
- View/download PDF
7. Balloon Angioplasty in Aortoiliac Arterial Occlusive Disease
- Author
-
Charlton-Ouw, Kristofer M., primary, Davies, Mark G., additional, and Lumsden, Alan B., additional
- Published
- 2011
- Full Text
- View/download PDF
8. Intravascular Stenting in Aortoiliac Arterial Occlusive Disease
- Author
-
Charlton-Ouw, Kristofer M., primary, Davies, Mark G., additional, and Lumsden, Alan B., additional
- Published
- 2011
- Full Text
- View/download PDF
9. Intimal Hyperplasia
- Author
-
Davies, Mark G., primary
- Published
- 2010
- Full Text
- View/download PDF
10. Contributors
- Author
-
Abou-Zamzam, Ahmed M., primary, Abularrage, Christopher J., additional, AbuRahma, Ali F., additional, Acosta, Stefan, additional, Adams, Harold P., additional, Aidinian, Gilbert, additional, Akar, A. Ruchan, additional, Alimi, Yves S., additional, Andros, George, additional, Arcelus, Juan I., additional, Armstrong, David G., additional, Armstrong, Paul A., additional, Arora, Subodh, additional, Arthurs, Zachary M., additional, Ascher, Enrico, additional, Atkins, Marvin D., additional, Atnip, Robert G., additional, Aziz, Faisal, additional, Back, Martin R., additional, Ballard, Jeffrey L., additional, Bandyk, Dennis F., additional, Bartholomew, John R., additional, Baumeister, Ruediger G.H., additional, Bavaria, Joseph E., additional, Bechara, Carlos F., additional, Belkin, Michael, additional, Berceli, Scott A., additional, Bernas, Michael J., additional, Björck, Martin, additional, Black, James H., additional, Blankensteijn, Jan D., additional, Bower, Thomas C., additional, Brinkman, William T., additional, Brummel-Ziedins, Kathleen E., additional, Bush, Ruth L., additional, Calligaro, Keith D., additional, Cambria, Richard P., additional, Cao, Piergiorgio, additional, Caprini, Joseph A., additional, Carlson, Gregory D., additional, Carleton, T. Johelen, additional, Carpenter, Jeffrey P., additional, Chaikof, Elliot L., additional, Charlton-Ouw, Kristofer M., additional, Cheng, Stephen W.K., additional, Cho, Jae Sung, additional, Chuter, Timothy A.M., additional, Cinà, Claudio S., additional, Clair, Daniel G., additional, Clouse, W. Darrin, additional, Coggia, Marc, additional, Coimbra, Raul, additional, Comerota, Anthony J., additional, Conrad, Mark F., additional, Cooper, Leslie T., additional, Conte, Michael S., additional, Corriere, Matthew A., additional, Crawford, Robert S., additional, Cull, David L., additional, Dalman, Ronald L., additional, Dalsing, Michael C., additional, Dardik, Alan, additional, Darling, R. Clement, additional, Davies, Mark G., additional, DeLoach, Stephanie S., additional, Demetriades, Demetrios, additional, DePalma, Ralph G., additional, De Rango, Paola, additional, Dosluoglu, Hasan H., additional, Dougherty, Matthew J., additional, Driskill, Matt, additional, Duncan, Audra A., additional, Durdu, Serkan, additional, Earnshaw, Jonothan J., additional, Eberhardt, Robert T., additional, Edwards, James M., additional, Edwards, Matthew S., additional, Eidt, John F., additional, Endean, Eric, additional, Eskandari, Mark K., additional, Farber, Alik, additional, Faries, Peter L., additional, Fillinger, Mark F., additional, Fishman, Steven J., additional, Fitzgerald, Tamara N., additional, Forbes, Thomas L., additional, Fox, Charles J., additional, Gamble, Gail L., additional, Garvin, Robert P., additional, Geary, Randolph L., additional, Gillespie, David L., additional, Gloviczki, Peter, additional, Godshall, Christopher J., additional, Goëau-Brissonnière, Olivier, additional, Gornik, Heather L., additional, Gottsäter, Anders, additional, Greenberg, Roy K., additional, Greene, Arin K., additional, Griffith, Nathan M., additional, Guttmann, Geoffrey D., additional, Guzman, Raul J., additional, Hamdan, Allen, additional, Hamming, Jaap F., additional, Hansen, Kimberley J., additional, Harris, Linda M., additional, Hartung, Olivier, additional, Henke, Peter K., additional, Hingorani, Anil P., additional, Hoballah, Jamal J., additional, Hodgson, Kim J., additional, Hood, Douglas B., additional, Howard, Wm. James, additional, Hoyt, David B., additional, Huang, Christina, additional, Huber, Thomas S., additional, Hunter, Glenn C., additional, Iafrati, Mark D., additional, Illig, Karl A., additional, Inaba, Kenji, additional, Jacobowitz, Glenn R., additional, Jacobs, Michael J., additional, Jimenez, Juan Carlos, additional, Jordan, William D., additional, Kabnick, Lowell S., additional, Kalapatapu, Venkat R., additional, Kalra, Manju, additional, Kashyap, Vikram S., additional, Kasirajan, Karthikeshwar, additional, Kauffman, Paulo, additional, Killewich, Lois A., additional, Kim, Esther S.H., additional, Kohler, Ted R., additional, Kresowik, Timothy F., additional, Labropoulos, Nicos, additional, Lal, Brajesh K., additional, Landry, Gregory J., additional, Lau, David L., additional, Lavery, Lawrence A., additional, Lawrence, Peter F., additional, Lawson, Jeffrey H., additional, Lee, Byung-Boong, additional, Lee, W. Anthony, additional, León, Luis R., additional, Lew, Wesley K., additional, Liapis, Christos, additional, Liebman, Howard A., additional, Lilly, Michael P., additional, Lin, Peter H., additional, Lindblad, Bengt, additional, Lindsay, Thomas F., additional, Lipsett, Pamela A., additional, Litt, Harold, additional, Locke, Jayme E., additional, Lohr, Joann, additional, Longo, G. Matthew, additional, Lumsden, Alan B., additional, Lurie, Fedor, additional, Lynch, Thomas G., additional, Mackey, William C., additional, Macsata, Robyn A., additional, Makaroun, Michel S., additional, Maldonado, Thomas S., additional, Mann, Kenneth G., additional, Markose, George, additional, Marston, William A., additional, Martinez, Carlo O., additional, Matsumura, Jon S., additional, McKinsey, James F., additional, McLafferty, Robert B., additional, Meier, George H., additional, Menard, Matthew T., additional, Messina, Louis M., additional, Mills, Joseph L., additional, Modrall, J. Gregory, additional, Mohler, Emile, additional, Moneta, Gregory L., additional, Morasch, Mark D., additional, Myers, Stuart I., additional, Naylor, A. Ross, additional, Neglén, Peter, additional, Nguyen, Louis L., additional, O'Donnell, Thomas F., additional, O’Hara, Patrick J., additional, Ohki, Takao, additional, Oldenburg, W. Andrew, additional, Olin, Jeffrey W., additional, Owens, Christopher D., additional, Papia, Giuseppe, additional, Partsch, Hugo, additional, Passman, Marc A., additional, Patel, Himanshu J., additional, Patel, Kaushal R., additional, Pearce, Benjamin, additional, Perler, Bruce A., additional, Poldermans, Don, additional, Pomposelli, Frank B., additional, Pounds, Lori L., additional, Powell, Richard J., additional, Puggioni, Alessandra, additional, Qu, Zheng, additional, Quinn, Brendon M., additional, Quinones-Baldrich, William J., additional, Raffetto, Joseph D., additional, Raju, Seshadri, additional, Rana, Nabeel R., additional, Rasmussen, Todd E., additional, Reddy, Daniel J., additional, Rigberg, David, additional, Rockman, Caron B., additional, Rockson, Stanley G., additional, Roddy, Sean P., additional, Rogers, Lee C., additional, Roseborough, Glen S., additional, Rowe, Vincent L., additional, Rubin, Brian G., additional, Rzucidlo, Eva M., additional, Sadek, Mikel, additional, Safi, Hazim J., additional, Sambol, Elliot B., additional, Sanders, Richard J., additional, Schanzer, Andres, additional, Schneider, Darren, additional, Schneider, Joseph R., additional, Schneider, Peter A., additional, Schouten, Olaf, additional, Schroeder, Torben V., additional, Kool, Leo J. Schultze, additional, Schumacher, Paul M., additional, Schurink, Geert Willem, additional, Sheehan, Peter, additional, Shireman, Paula K., additional, Sicard, Gregorio A., additional, Sidawy, Anton N., additional, Sileshi, Bantayehu, additional, Singh, Niten N., additional, Smith, Stephen T., additional, Starnes, Benjamin W., additional, Sternbergh, W. Charles, additional, Stone, David H., additional, Sumi, Makoto, additional, Sumner, David S., additional, Sumpio, Bauer, additional, Svensson, Lars G., additional, Taylor, Spence M., additional, Tedesco, Maureen M., additional, Tillman, Bryan W., additional, Thompson, Robert W., additional, Timaran, Carlos H., additional, Upchurch, Gilbert R., additional, Valentine, R. James, additional, van Bockel, J. Hajo, additional, Vandy, Frank C., additional, Villavicencio, Leonel, additional, Vogt, Katja C., additional, Wakefield, Thomas W., additional, Walcott, Roger, additional, Walsh, Daniel B., additional, Warrington, Kenneth J., additional, Watkins, Michael T., additional, Weaver, Fred A., additional, Weaver, Mitchell R., additional, Weitz, Ilene C., additional, White, John V., additional, Wietz, Jeffrey I., additional, Witte, Marlys H., additional, Wolosker, Nelson, additional, Wyers, Mark C., additional, York, John W., additional, Zhang, Wayne W., additional, and Zierler, R. Eugene, additional
- Published
- 2010
- Full Text
- View/download PDF
11. The ready reckoner
- Author
-
Davies, Mark, primary
- Published
- 2009
- Full Text
- View/download PDF
12. Resuscitation
- Author
-
Cartwright, David, primary, Inglis, Garry, additional, and Davies, Mark, additional
- Published
- 2009
- Full Text
- View/download PDF
13. Chronic lung disease (CLD)
- Author
-
Davies, Mark, primary and Inglis, Garry, additional
- Published
- 2009
- Full Text
- View/download PDF
14. Apnoea
- Author
-
Cartwright, David, primary and Davies, Mark, additional
- Published
- 2009
- Full Text
- View/download PDF
15. Blood gas results
- Author
-
Cartwright, David, primary and Davies, Mark, additional
- Published
- 2009
- Full Text
- View/download PDF
16. Maternal infections
- Author
-
Inglis, Garry, primary, Davies, Mark, additional, and Cartwright, David, additional
- Published
- 2009
- Full Text
- View/download PDF
17. Care of the extremely preterm baby
- Author
-
Davies, Mark, primary and Cartwright, David, additional
- Published
- 2009
- Full Text
- View/download PDF
18. Retinopathy of prematurity (ROP)
- Author
-
Davies, Mark, primary and Inglis, Garry, additional
- Published
- 2009
- Full Text
- View/download PDF
19. Pulmonary hypertension
- Author
-
Davies, Mark, primary
- Published
- 2009
- Full Text
- View/download PDF
20. Maternal thyroid disease
- Author
-
Davies, Mark, primary
- Published
- 2009
- Full Text
- View/download PDF
21. Procedures
- Author
-
Cartwright, David, primary and Davies, Mark, additional
- Published
- 2009
- Full Text
- View/download PDF
22. Neonatal abstinence syndrome (NAS)
- Author
-
Davies, Mark, primary and Cartwright, David, additional
- Published
- 2009
- Full Text
- View/download PDF
23. Surgical problems
- Author
-
Davies, Mark, primary and Inglis, Garry, additional
- Published
- 2009
- Full Text
- View/download PDF
24. Jaundice
- Author
-
Cartwright, David, primary, Inglis, Garry, additional, and Davies, Mark, additional
- Published
- 2009
- Full Text
- View/download PDF
25. Withdrawal of treatment
- Author
-
Davies, Mark, primary and Cartwright, David, additional
- Published
- 2009
- Full Text
- View/download PDF
26. Cranial ultrasounds
- Author
-
Davies, Mark, primary and Cartwright, David, additional
- Published
- 2009
- Full Text
- View/download PDF
27. Respiratory support
- Author
-
Davies, Mark, primary, Cartwright, David, additional, and Jardine, Luke, additional
- Published
- 2009
- Full Text
- View/download PDF
28. Common drugs and infusions
- Author
-
Davies, Mark, primary and Cartwright, David, additional
- Published
- 2009
- Full Text
- View/download PDF
29. Outcome statistics
- Author
-
Davies, Mark, primary
- Published
- 2009
- Full Text
- View/download PDF
30. Death
- Author
-
Davies, Mark, primary and Cartwright, David, additional
- Published
- 2009
- Full Text
- View/download PDF
31. Seizures
- Author
-
Davies, Mark, primary and Cartwright, David, additional
- Published
- 2009
- Full Text
- View/download PDF
32. Blood pressure
- Author
-
Davies, Mark, primary
- Published
- 2009
- Full Text
- View/download PDF
33. Infection control — hand hygiene
- Author
-
Cartwright, David, primary and Davies, Mark, additional
- Published
- 2009
- Full Text
- View/download PDF
34. Preface
- Author
-
Davies, Mark W, primary, Cartwright, David W, additional, and Inglis, Garry DT, additional
- Published
- 2009
- Full Text
- View/download PDF
35. Fluids and nutrition
- Author
-
Davies, Mark, primary, Cartwright, David, additional, and Inglis, Garry, additional
- Published
- 2009
- Full Text
- View/download PDF
36. Anaemia and blood product transfusions
- Author
-
Davies, Mark, primary and Cartwright, David, additional
- Published
- 2009
- Full Text
- View/download PDF
37. Infection risk
- Author
-
Cartwright, David, primary, Davies, Mark, additional, and Inglis, Garry, additional
- Published
- 2009
- Full Text
- View/download PDF
38. Hypoglycaemia
- Author
-
Davies, Mark, primary and Cartwright, David, additional
- Published
- 2009
- Full Text
- View/download PDF
39. Mucus from Marine Molluscs
- Author
-
Davies, Mark S., primary and Hawkins, S.J., additional
- Published
- 1998
- Full Text
- View/download PDF
40. A biologically relevant rapid quantification of physical and biologicalstress profiles on rocky shores
- Author
-
Stafford, Richard, NG, Terence, Williams, Gray, Davies, Mark, and Mark Davies
- Subjects
Ecology ,biology ,Applied Mathematics ,Ecological Modeling ,media_common.quotation_subject ,Limpet ,Plankton ,biology.organism_classification ,Atmospheric sciences ,Competition (biology) ,Computer Science Applications ,Stress (mechanics) ,Rocky shore ,Computational Theory and Mathematics ,Modeling and Simulation ,Cellana ,Indicator species ,Environmental science ,Cellana grata ,Ecology, Evolution, Behavior and Systematics ,media_common ,sub_environment - Abstract
Different combinations and intensities of physical (e.g. thermal) and biological (e.g. competition or predation)\ud stress operate on organisms in different locations. Variation in these stresses can occur over small tomediumspatial\ud scales (cm to 10s of metres) in heterogeneous environments such as rocky shores, due to differences in sun\ud and wave exposure, shore topography and/or recruitment. In this study we demonstrate how simple measurements\ud can be taken that represent physical and biological stresses (stress profiles) in a given location. Using a\ud bootstrapped principal component analysis, we identified significantly different stress profiles at four sites separated\ud by only 10s to 100s of metres on the Shek O peninsula in Hong Kong.We then measured response to thermal\ud stress, as determined by detachment temperature, in the limpet Cellana grata (which is known to be a\ud sensitive indicator species to thermal stress) from each location. Significant differences in stress profile between\ud locations were also seen in thermal stress tolerance of limpets fromthose locations. At locationswhere the major\ud stresses are likely to be more physical or less biological in nature (e.g. southerly facing aspect or lower density of\ud grazers), the mean detachment temperature was higher, whereas detachment temperature was lower at sites\ud with more biological or less physical stress. This method is, therefore, able to determine biologically meaningful\ud differences in stress profiles over small to mediumspatial scales, and demonstrates that localised adaptation (i.e.\ud post planktonic settlement) or acclimation of species may occur in response to these different stress profiles. The\ud technique can be adapted to different environments and smaller or larger spatial scales as long as the stress\ud experienced by the study species is relevant to these scales.
- Published
- 2014
41. Inter-species genetic movement may blur the epidemiology of streptococcal diseases in endemic regions
- Author
-
Davies, Mark R., Tran, Thanh N., McMillan, David J., Gardiner, Donald L., Currie, Bart J., Sriprakash, Kadaba S., Davies, Mark R., Tran, Thanh N., McMillan, David J., Gardiner, Donald L., Currie, Bart J., and Sriprakash, Kadaba S.
- Abstract
Streptococcus dysgalactiae subsp. equisimilis (human group G streptococcus, GGS) is generally regarded as a commensal organism but can cause a spectrum of human diseases very similar to that caused by S. pyogenes (group A streptococcus, GAS). Lateral acquisition of genes between these two phylogenetic ally closely related species is well documented. However, the extent and mechanisms of lateral acquisitions is not known. We report here genomic subtraction between a pathogenic GGS isolate and a community GGS isolate and analyses of the gene sequences unique to the pathovar. Our results show that cross-species genetic transfers are common between GGS and two closely related human pathogens, GAS and the group B streptococcus. We also demonstrate that mobile genetic elements, such as phages and transposons, play an important role in the ongoing inter-species transfers of genetic traits between extant organisms in the community. Furthermore, lateral gene transfers between GAS and GGS may occur more frequently in geographical regions of high GAS endemicity. These observations may have important implications in understanding the epidemiology of streptococcal diseases in such regions.
- Published
- 2005
42. Pedal medial arterial calcification influences the outcomes of isolated infra-malleolar interventions for chronic limb-threatening ischemia.
- Author
-
Cheun TJ, Hart JP, and Davies MG
- Subjects
- Humans, Male, Female, Aged, Retrospective Studies, Middle Aged, Risk Factors, Databases, Factual, Time Factors, Treatment Outcome, Risk Assessment, Progression-Free Survival, Ischemia surgery, Ischemia mortality, Ischemia diagnostic imaging, Ischemia physiopathology, Aged, 80 and over, Amputation, Surgical, Vascular Calcification diagnostic imaging, Vascular Calcification mortality, Vascular Calcification complications, Vascular Calcification therapy, Vascular Calcification surgery, Endovascular Procedures adverse effects, Endovascular Procedures mortality, Chronic Limb-Threatening Ischemia surgery, Chronic Limb-Threatening Ischemia complications, Peripheral Arterial Disease diagnostic imaging, Peripheral Arterial Disease mortality, Peripheral Arterial Disease surgery, Peripheral Arterial Disease physiopathology, Peripheral Arterial Disease complications, Peripheral Arterial Disease therapy, Limb Salvage
- Abstract
Objective: Inframalleolar disease is present in most diabetic patients presenting with tissue loss. Inframalleolar (pedal) artery disease and pedal medial arterial calcification (pMAC) are associated with major amputation in patients with chronic limb-threatening ischemia (CLTI). This study aimed to examine the impact of pMAC on the outcomes after isolated inframalleolar (pedal artery) interventions., Methods: A database of lower extremity endovascular intervention for patients with tissue loss between 2007 and 2022 was retrospectively queried. Patients with CLTI were selected, and those undergoing isolated inframalleolar intervention on the dorsalis pedis and medial and lateral tarsal arteries and who had foot x-rays were identified. X-rays were assessed blindly for pMAC and scored on a scale of 0 to 5. Patients with concomitant superficial femoral artery and tibial interventions were excluded. Intention to treat analysis by the patient was performed. Amputation-free survival (survival without major amputation) was evaluated., Results: A total of 223 patients (51% female; 87% Hispanic; average age, 66 years; 323 vessels) underwent isolated infra-malleolar intervention for tissue loss. All patients had diabetes, 96% had hypertension, 79% had hyperlipidemia, and 63% had chronic renal insufficiency (55% of these were on hemodialysis). Most of the patients had Wound, Ischemia, and foot Infection (WIfI) stage 3 disease and had various stages of pMAC: severe (score = 5) in 48%, moderate (score = 2-4) in 31%, and mild (score = 0-1) in 21% of the patients. Technical success was 94%, with a median of one vessel treated per patient. All failures were in severe pMAC. Overall, major adverse cardiovascular events was 0.9% at 90 days after the procedure. Following the intervention, most patients underwent a planned forefoot amputation (single digit, multiple digits, ray amputation, or trans-metatarsal amputation). WIfI ischemic grade was improved by 51%. Wound healing at 3 months was 69%. Those not healing underwent below-knee amputations. The overall 5-year amputation-free survival rate was 35% ± 9%. The severity of pMAC was associated with decreased AFS., Conclusions: Increasing severity of pMAC influences the technical and long-term outcomes of infra-malleolar intervention in diabetes. Severe pMAC is associated with amputation and should be considered as a variable in the shared decision-making of diabetic patients with CLTI., Competing Interests: Disclosures None., (Copyright © 2024 Society for Vascular Surgery. Published by Elsevier Inc. All rights reserved.)
- Published
- 2024
- Full Text
- View/download PDF
43. Influence of a Novel Morphology-Driven Classification on Limb Salvage after Isolated Tibial Intervention for Chronic Limb Threatening Ischemia.
- Author
-
Cheun TJ and Davies MG
- Subjects
- Humans, Male, Retrospective Studies, Female, Aged, Risk Factors, Time Factors, Middle Aged, Risk Assessment, Endovascular Procedures adverse effects, Endovascular Procedures instrumentation, Progression-Free Survival, Aged, 80 and over, Treatment Outcome, Ischemia physiopathology, Ischemia surgery, Ischemia diagnostic imaging, Ischemia therapy, Limb Salvage, Amputation, Surgical, Vascular Patency, Peripheral Arterial Disease physiopathology, Peripheral Arterial Disease diagnostic imaging, Peripheral Arterial Disease therapy, Peripheral Arterial Disease surgery, Tibial Arteries physiopathology, Tibial Arteries diagnostic imaging, Tibial Arteries surgery, Databases, Factual, Chronic Limb-Threatening Ischemia surgery
- Abstract
Background: Infra-popliteal interventions for chronic limb-threatening ischemia (CLTI) can be impacted by the morphology of the tibial vessels. The aim of this study was to examine the impact of a novel morphology-driven classification on the outcomes of isolated tibial intervention for CLTI., Methods: A database of patients undergoing isolated tibial interventions for CLTI at a single center between 2010 and 2020 was retrospectively queried. Patients with isolated infra-popliteal disease were identified, and their anatomy was scored as present or absent for lesion calcification (1 point), target vessel diameter<3.0 mm (1 point), lesion length>300 mm (1 point), and poor pedal runoff score (1 point). Patients were then divided into 3 groups: low risk (0 or 1 points), moderate risk (2 points), and high risk (3 or 4 points). Intention to treat analysis by the patient was performed. Limb-based patency (the absence of reintervention, occlusion, critical stenosis [>70%], or hemodynamic compromise with ongoing symptoms of CLTI as it related to the patency of the preoperatively determined target artery pathway) was assessed. Patient-oriented outcomes of amputation-free survival (AFS; survival without major amputation) and freedom from major adverse limb events (MALE; above ankle amputation of the index limb or major reintervention: new bypass graft, jump/interposition graft revision) were evaluated., Results: 1,607 patients (55% male, average age 60 years, 3,846 vessels) underwent tibial intervention for CLTI. The majority of the patients were diabetic and of Hispanic origin. Morphologically, 27%, 31%, and 42% of the vessels were categorized as low risk, moderate risk, and high risk, respectively. There was a significant worsening of the infra-popliteal Global Limb Anatomic Staging System (GLASS) grading as the morphological risk increased. The 30-day major adverse cardiac events (MACE) were equivalent across the groups and were under the stated objective performance goal (OPG) of ≤10%. In contrast, both the 30-day MALE and the 30-day major amputations were significantly different across the groups, with the low-risk group remaining under the OPG of ≤9% and ≤4%, respectively, while the moderate risk and high risk exceeded the goal threshold. For the OPG, freedom from MALE was 60 ± 5%, 46 ± 5%, and 22 ± 9% at 5 years for low-, moderate-, and high-risk groups, respectively (mean ± standard error of the mean; P = 0.008). Overall AFS was 55 ± 5%, 37 ± 6%, and 18 ± 7% at 5 years for low-, moderate-, and high-risk groups, respectively (mean ± standard error of the mean; P = 0.003)., Conclusions: Tibial anatomic morphology impacts isolated tibial endovascular intervention with adverse morphology associated with poorer short- and long-term outcomes. Risk stratification based on anatomic predictors should be an additional consideration as one intervenes on infra-popliteal vessels for CLTI., (Copyright © 2024 Elsevier Inc. All rights reserved.)
- Published
- 2024
- Full Text
- View/download PDF
44. Management of depth to achieve timely arteriovenous fistula utilization.
- Author
-
Cheun TJ, Hart JP, and Davies MG
- Subjects
- Humans, Retrospective Studies, Female, Male, Middle Aged, Time Factors, Aged, Treatment Outcome, Radial Artery surgery, Risk Factors, Vascular Patency, Embolization, Therapeutic adverse effects, Brachial Artery surgery, Brachiocephalic Veins surgery, Brachiocephalic Veins diagnostic imaging, Upper Extremity blood supply, Graft Occlusion, Vascular etiology, Graft Occlusion, Vascular therapy, Graft Occlusion, Vascular physiopathology, Arteriovenous Shunt, Surgical adverse effects, Renal Dialysis
- Abstract
Objective: Failure to achieve timely arteriovenous fistulae (AVFs) utilization due to excessive depth (>6 mm) remains an ongoing concern for dialysis access. This study evaluates the outcomes of radiocephalic (RCF) and brachiocephalic (BCF) fistula elevation required for access utilization., Methods: A retrospective review of all patients undergoing first-time autologous access over 10 years was undertaken. RCF and BCF were analyzed, and cases of initial access failure due to depth alone were selected for study. Primary and staged brachio-basilic AVF were excluded. Outcomes of early thrombosis, line placement, maturation (successful progression to hemodialysis [HD), reintervention, and functional dialysis (continuous HD for 3 consecutive months) were examined., Results: From January 2012 to December 2022, 1733 patients (67% female; mean age, 61 ± 14 years) underwent autologous AVF placement. Of these, 298 patients (17%) had depth-related AVF access issues (BCF, 71% and RCF, 29%). Nineteen percent of these AVFs underwent a primary balloon-assisted maturation (BAM), and 2% had side branch coil embolization before consideration for elevation. The average time to intervention for depth was 11 ± 4 weeks after primary creation. During elevation, side branch ligation occurred in 38% of cases, and 15% underwent intraoperative BAM, The pre-elevation depth was 8.2 ± 3.1 mm, and the mean post-elevation depth was 4.7 ± 2.9 mm (P = .002). Early thrombosis (<18 days) occurred in 4% of cases. There was no mortality, and the 30-day major adverse cardiac event rate was 2%, with a 30-day morbidity of 5%, which was driven by wound issues. Six percent of the AVFs underwent follow-up BAM within 3 months. Mean maturation of the AVFs was 74% ± 3% vs 72% ± 3% (P = .58) for the elevation vs no-elevation groups at 24 weeks, respectively. However, there was an increase in tunneled central line placement in pre-emptive fistula patients due to the delay in maturation (elevation, 17% vs no-elevation, 8%; P = .008). There was a mean successful access time of 6 ± 3 weeks after elevation (16 ± 4 weeks after access creation). There was a median of 2.4 secondary interventions per year after elevation compared with a median of 2.7 secondary interventions per year without elevation. Mean access functionality was 68% ± 8% vs 75% ± 8% at 3 years for the elevation vs no-elevation groups, respectively (P = .25)., Conclusions: Elevation of deep BCF and RCF occurs late after placement but can be successfully achieved with low morbidity and satisfactory long-term functionality. It results in an increase in tunneled central line placement in pre-emptive fistula patients. Elevation is a valuable adjunct to AVF maturation and enhances an autologous access policy., Competing Interests: Disclosures None., (Copyright © 2024 Society for Vascular Surgery. Published by Elsevier Inc. All rights reserved.)
- Published
- 2024
- Full Text
- View/download PDF
45. Extracorporal Membrane Oxygenation in Massive Pulmonary Embolism.
- Author
-
Davies MG and Hart JP
- Subjects
- Humans, Treatment Outcome, Risk Factors, Hemodynamics, Recovery of Function, Clinical Decision-Making, Risk Assessment, Extracorporeal Membrane Oxygenation adverse effects, Extracorporeal Membrane Oxygenation mortality, Pulmonary Embolism therapy, Pulmonary Embolism physiopathology, Pulmonary Embolism mortality, Pulmonary Embolism diagnostic imaging
- Abstract
Background: Massive pulmonary embolism (MPE) carries significant 30-day mortality risk, and a change in societal guidelines has promoted the increasing use of extracorporeal membrane oxygenation (ECMO) in the immediate management of MPE-associated cardiovascular shock. This narrative review examines the current status of ECMO in MPE., Methods: A literature review was performed from 1982 to 2022 searching for the terms "Pulmonary embolism" and "ECMO," and the search was refined by examining those publications that covered MPE., Results: In the patient with MPE, veno-arterial ECMO is now recommended as a bridge to interventional therapy. It can reliably decrease right ventricular overload, improve RV function, and allow hemodynamic stability and restoration of tissue oxygenation. The use of ECMO in MPE has been associated with lower mortality in registry reviews, but there has been no significant difference in outcomes between patients treated with and without ECMO in meta-analyses. Applying ECMO is also associated with substantial multisystem morbidity due to systemic inflammatory response, bleeding with coagulopathy, hemorrhagic stroke, renal dysfunction, and acute limb ischemia, which must be factored into the outcomes., Conclusions: The application of ECMO in MPE should be combined with an aggressive interventional pulmonary interventional program and should strictly adhere to the current selection criteria., (Copyright © 2024 Elsevier Inc. All rights reserved.)
- Published
- 2024
- Full Text
- View/download PDF
46. Quantifying the Value of Reduced Health Disparities: Low-Dose Computed Tomography Lung Cancer Screening of High-Risk Individuals Within the United States.
- Author
-
Shafrin J, Kim J, Marin M, Ramsagar S, Davies ML, Stewart K, Kalsekar I, and Vachani A
- Subjects
- Humans, United States, Quality of Life, Mass Screening, Cost-Benefit Analysis, Tomography, X-Ray Computed methods, Health Inequities, Early Detection of Cancer, Lung Neoplasms diagnostic imaging, Lung Neoplasms epidemiology
- Abstract
Objective: This study aimed to measure the value of increasing lung cancer screening rates for high-risk individuals and its impact on health disparities., Methods: The model estimated changes in health economic outcomes if low-dose computed tomography screening increased from current to 100% compliance, following clinical guidelines. Current low-dose computed tomography screening rates were estimated by income, education, and race, using 2017-2019 Behavioral Risk Factor Surveillance System data. The model contained a decision tree module to segment the population by screening outcomes and a Markov chain module to estimate cancer progression over time. Model parameters included information on survival, quality of life, and costs related to cancer diagnosis, treatment, and adverse events. Distributional cost-effectiveness analysis estimated the net monetary value from reduced health disparities-measured using quality-adjusted life expectancy-across income, education, and race groups. Outcomes were assessed over 30 years., Results: Lung cancer screening eligibility using US Preventive Services Task Force guidelines was higher for individuals with income <$15 000 (47.2%) and without a high-school education (46.1%) than individuals with income >$50 000 (16.6%) and with a college degree (13.5%), respectively. Increasing lung cancer screening to 100% compliance was cost-effective ($64 654 per quality-adjusted life-year) and produced economic value by up to $560 per person ($182.1 billion for United States overall). Up to 32.2% of the value was due to reductions in health disparities., Conclusions: Significant value in increasing lung cancer screening rates derived from reducing health disparities. Policy makers and clinicians may not be appropriately prioritizing cancer screening if value from reducing health disparities is unconsidered., Competing Interests: Author Disclosures Links to the disclosure forms provided by the authors are available here., (Copyright © 2024. Published by Elsevier Inc.)
- Published
- 2024
- Full Text
- View/download PDF
47. Outcomes of one-stage and two-stage aneurysm repair in arteriovenous fistulae.
- Author
-
Yan Q and Davies MG
- Subjects
- Humans, Treatment Outcome, Veins diagnostic imaging, Veins surgery, Renal Dialysis adverse effects, Retrospective Studies, Vascular Patency, Arteriovenous Shunt, Surgical adverse effects, Aneurysm diagnostic imaging, Aneurysm etiology, Aneurysm surgery, Arteriovenous Fistula complications, Thrombosis etiology
- Abstract
Objective: Maintenance of long-term arteriovenous access is important in long-term care for patients with end-stage renal disease. Arteriovenous access is associated in the long term with the development of fistula aneurysms (FAs). This study aims to evaluate the outcomes of staged FA treatment in dialysis access arteriovenous fistulae (AVF)., Methods: A retrospective review of all patients over a 12-year period with primary autogenous AVF was undertaken at a single center. Patients undergoing elective open aneurysm repair were identified and were categorized into three groups: single FA repair (single, control group) and staged and unstaged repair of two FAs (staged and unstaged). A staged repair was a procedure in which the initial intent was to treat both aneurysms in the AVF and in which the most symptomatic aneurysm was treated first. When the incision from the first surgery had healed, the second symptomatic aneurysm in the AVF was treated. An unstaged repair was a procedure in which the initial intent was to repair both symptomatic aneurysms simultaneously. All patients had a fistulogram before the FA repair. Thirty-day outcomes, cannulation failure, line placement, reintervention, and functional dialysis (continuous hemodialysis for 3 consecutive months) were examined., Results: Five hundred twenty-seven patients presented with FA that met requirements for open intervention; 44% underwent single FA repair, whereas the remaining 34% and 22% underwent staged and unstaged repair of two FAs, respectively. The majority of patients were diabetic and Hispanic. Ninety-one percent of the patients required percutaneous interventions of the outflow tract (37%) and the central veins (54%). Thirty-day major adverse cardiovascular events were equivalent across all modalities. Thirty-day morbidity and early thrombosis (<18 days) were significantly higher in the unstaged group (4.3%) compared with the two other groups (1.3% and 2.1%, single and staged, respectively), which led to an increased need for a short-term tunneled catheter (8.9%) compared with the two other groups (3.4% and 4.4%, single and staged, respectively), Unstaged repair resulted in an increased incidence of secondary procedures (5.0%) compared with the two other groups (2.6% and 3.1%, single and staged, respectively). Functional dialysis at 5 years was equivalent in the single and staged groups but was significantly decreased in the unstaged group., Conclusions: Open interventions are successful therapeutic modalities for FAs, but unstaged rather than staged repair of two concurrent FAs results in a higher early thrombosis, an increased secondary intervention rate, and a need for a short-term tunneled central line. Staged and single FA repairs have equivalent results. In the setting of two symptomatic FAs, staged repair is recommended., Competing Interests: Disclosures None., (Copyright © 2023 Society for Vascular Surgery. Published by Elsevier Inc. All rights reserved.)
- Published
- 2024
- Full Text
- View/download PDF
48. Comparison of Open and Endovascular Aneurysm Repair in Native Arteriovenous Fistulas.
- Author
-
Yan Q and Davies MG
- Subjects
- Humans, Endovascular Aneurysm Repair, Graft Occlusion, Vascular, Vascular Patency, Treatment Outcome, Renal Dialysis, Retrospective Studies, Arteriovenous Shunt, Surgical adverse effects, Aortic Aneurysm, Abdominal surgery, Endovascular Procedures adverse effects, Blood Vessel Prosthesis Implantation adverse effects, Arteriovenous Fistula surgery, Angioplasty, Balloon
- Abstract
Background: Arteriovenous accesses develop aneurysms (FA) during their active use, resulting in pain, erosion, bleeding, and difficulty in cannulation. This study aims to evaluate the outcomes of open and endovascular management of single FA in arteriovenous fistulas (AVF)., Methods: A retrospective review of all upper extremity primary AVFs over 12 years was undertaken at a single center. Patients undergoing elective open and endovascular repair of a single FA were identified. Thirty-day outcomes, cannulation failure, line placement, re-intervention, and functional dialysis (continuous hemodialysis) for 3 consecutive months were examined., Results: Three hundred and seventy nine patients presented with a single FA that met the requirements for intervention: 126 (33%) underwent endovascular repair, and the remainder 253 (67%) underwent open repair. Preoperative fistulogram identified anatomically significant issues in 91% of the cases, and these were treated by balloon angioplasty: 10% within the fistula tract, 44% within the outflow tract, and 47% in the central veins. In open repair, 57% underwent plication, 35% underwent resection and re-anastomosis, and the remainder (8%) underwent interposition grafting. In endovascular repair, successful placement of a stent was achieved in all cases with 1 ± 2 (mean ± standard deviation [SD]) covered stents (diameter: 6 -8 mm) placed, achieving successful exclusion of the FA. The combination of early thrombosis and cannulation failures led to the greater need for a tunneled central line in endovascular repair (6.5% vs. 2.4%; endovascular versus open repair; P = 0.04). As a result, the mean time for establishing renewed access in the index AVF was significantly higher in endovascular repair (2 ± 3 vs. 2 ± 2 weeks, mean ± SD; endovascular open repair versus open repair; P = 0.001). In follow-up, there were more secondary interventions per year in the endovascular compared to open repair groups (3.1 vs. 1.4 secondary interventions per year; endovascular versus open repair; P = 0.04). Median functional dialysis durations were superior in the open repair (48 ± 6%, mean + standard error) compared to the endovascular repair at 5 years. (26 ± 7%; P = 0.03)., Conclusions: Open repair results in a more rapid return to access use, lower need for a tunneled central line, lower secondary re-intervention rates, and superior functional dialysis durations compared to endovascular repair. Open FA repair should be considered for symptomatic single FA repairs before endovascular FA repair., (Copyright © 2023 Elsevier Inc. All rights reserved.)
- Published
- 2024
- Full Text
- View/download PDF
49. Cryothermal energy demonstrates shorter ablation time and lower complication rates compared with radiofrequency in surgical hybrid ablation for recurrent ventricular tachycardia.
- Author
-
Chung WH, Hayase J, Davies MJ, Do DH, Sorg JM, Ajijola OA, Buch EF, Boyle NG, Shivkumar K, and Bradfield JS
- Subjects
- Humans, Retrospective Studies, Endocardium, Pericardium surgery, Treatment Outcome, Tachycardia, Ventricular, Catheter Ablation adverse effects, Catheter Ablation methods
- Abstract
Background: Recurrent ventricular tachycardia (VT) after prior endocardial catheter ablation(s) presents challenges in the setting of prior cardiac surgery where percutaneous epicardial access may not be feasible., Objective: The purpose of this study was to compare the outcomes of cryothermal vs radiofrequency ablation in direct surgical epicardial access procedures., Methods: We performed a retrospective study of consecutive surgical epicardial VT ablation cases. Surgical cases using cryothermal vs radiofrequency ablation were analyzed and outcomes were compared., Results: Between 2009 and 2022, 43 patients underwent either a cryothermal (n = 17) or a radiofrequency (n = 26) hybrid epicardial ablation procedure with direct surgical access. Both groups were similarly matched for age, sex, etiology of VT, and comorbidities with a high burden of refractory VT despite previous endocardial and/or percutaneous epicardial ablation procedures. The surgical access site was lateral thoracotomy (76.5%) in the cryothermal ablation group compared with lateral thoracotomy (42.3%) and subxiphoid approach (38.5%) in the radiofrequency group, with the remainder in both groups performed via median sternotomy. The ablation time was significantly shorter in those undergoing cryothermal ablation vs radiofrequency ablation (11.54 ± 15.5 minutes vs 48.48 ± 23.6 minutes; P < .001). There were no complications in the cryothermal ablation group compared with 6 patients with complications in the radiofrequency group. Recurrent VT episodes and all-cause mortality were similar in both groups., Conclusion: Hybrid surgical VT ablation with cryothermal or radiofrequency energy demonstrated similar efficacy outcomes. Cryothermal ablation was more efficient and safer than radiofrequency in a surgical setting and should be considered when surgical access is required., (Copyright © 2023 Heart Rhythm Society. All rights reserved.)
- Published
- 2023
- Full Text
- View/download PDF
50. Obesity drives secondary procedures to achieve access maturation in end-stage renal disease.
- Author
-
Yan Q and Davies MG
- Subjects
- Humans, Female, Middle Aged, Aged, Male, Treatment Outcome, Vascular Patency, Renal Dialysis, Obesity complications, Obesity diagnosis, Obesity epidemiology, Retrospective Studies, Arteriovenous Shunt, Surgical adverse effects, Arteriovenous Shunt, Surgical methods, Kidney Failure, Chronic diagnosis, Kidney Failure, Chronic therapy, Kidney Failure, Chronic etiology
- Abstract
Background: Establishing long-term arteriovenous access is an important component in the long-term care of a patient with end-stage renal disease. The increasing frequency of obesity is reported to impact the access management of end-stage renal disease patients. This study aims to evaluate the outcomes of arteriovenous fistulae (AVF) in obese and nonobese patients., Methods: A retrospective review of all patients over ten years with primary autogenous AVF (radiocephalic, brachiocephalic, and brachial-basilic) was undertaken at a single center. Patients were subcategorized by body mass index into nonobese, class I, II, and III obesity. Outcomes of maturation (successful progression to hemodialysis), reintervention, functional dialysis (continuous hemodialysis for 3 consecutive months), and patency were examined., Results: From January 1999 to December 2019, 2311 patients (67% female; mean age, 61 ± 15 years) underwent primary AVF placement (12% radiocephalic, 53% brachiocephalic, and 35% brachial basilic). Forty-one percent were nonobese, 29% had class I obesity, 19% had class II obesity, and 11% had class III obesity. The majority of patients were diabetic and Hispanic. The 30-day major adverse cardiovascular event rate was elevated in class II (0.20%) and class III (0.50%) obesity compared with class I obesity (0.15%) and nonobese (0.05%). The 30-day morbidity rate was higher in all classes of obesity (0.5% vs0.3% vs 0.2% vs 0.05% for class III vs class II vs class I obesity and nonobese, respectively). Early thrombosis was significantly increased in class II (9%) and class III obesity (12%) compared with class I obesity (5%) and nonobese (3%). There was a two-fold increase in procedures to effect maturation in class II (51%) and class III (74%) obesity compared with class I obesity (22%) and nonobese (34%). Secondary patency at 3 years was significantly lower in class III (62 ± 4%) and class II (79 ± 3%) compared with class I obesity (87 ± 2%) and nonobese (93 ± 4%). All classes of obesity required significantly more secondary Interventions per year compared with nonobese (3.9 vs 3.1 vs 2.5 vs 1.4 secondary interventions per year for class III vs class II vs class I obesity and nonobese, respectively)., Conclusions: Advancing obesity class is associated with an increased number of procedures to achieve AVF maturation and is associated with poorer patency and functionality as the category of obesity advances., Competing Interests: Disclosures None., (Copyright © 2023 Society for Vascular Surgery. Published by Elsevier Inc. All rights reserved.)
- Published
- 2023
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.